SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1evl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NYR_A_THRA1004_0
(THREONYL-TRNA
SYNTHETASE 1)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		8 / 10 MET A 332
CYH A 334
ARG A 363
ASP A 383
HIS A 385
TYR A 462
GLN A 484
HIS A 511
 TSB  A2002 (-3.4A)
ZN  A   1 ( 2.4A)
TSB  A2002 (-2.7A)
TSB  A2002 (-2.8A)
ZN  A   1 ( 3.3A)
None
TSB  A2002 (-3.3A)
ZN  A   1 ( 3.2A)
 0.35A 1nyrA-1evlA:
52.6		 1nyrA-1evlA:
41.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1NYR_B_THRB2004_0
(THREONYL-TRNA
SYNTHETASE 1)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		8 / 10 MET A 332
CYH A 334
ARG A 363
ASP A 383
HIS A 385
TYR A 462
GLN A 484
HIS A 511
 TSB  A2002 (-3.4A)
ZN  A   1 ( 2.4A)
TSB  A2002 (-2.7A)
TSB  A2002 (-2.8A)
ZN  A   1 ( 3.3A)
None
TSB  A2002 (-3.3A)
ZN  A   1 ( 3.2A)
 0.73A 1nyrB-1evlA:
49.3		 1nyrB-1evlA:
41.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 5 MET A 355
HIS A 385
ILE A 329
HIS A 309
 None
ZN  A   1 ( 3.3A)
None
None
 1.11A 1osvB-1evlA:
0.0		 1osvB-1evlA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 ARG A 354
SER A 409
TYR A 408
 None
 0.45A 1x70A-1evlA:
0.0		 1x70A-1evlA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 TYR A 313
ARG A 363
TYR A 462
GLY A 459
ALA A 460
 None
TSB  A2002 (-2.7A)
None
None
None
 1.24A 2cojA-1evlA:
undetectable
2cojB-1evlA:
undetectable		 2cojA-1evlA:
23.97
2cojB-1evlA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC8_0
(ACTINOMYCIN D)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 PRO A 464
THR A 422
PRO A 424
 None
 0.58A 2d55C-1evlA:
undetectable		 2d55C-1evlA:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 ILE A 524
GLY A 372
HIS A 371
ARG A 476
GLY A 523
 None
 1.20A 2fn1A-1evlA:
undetectable		 2fn1A-1evlA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 ILE A 524
GLY A 372
HIS A 371
ARG A 476
GLY A 523
 None
 1.16A 2fn1B-1evlA:
undetectable		 2fn1B-1evlA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 ALA A 565
ALA A 538
ILE A 632
LEU A 640
MET A 619
 None
 1.02A 2nyrA-1evlA:
undetectable		 2nyrA-1evlA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PK4_A_ACAA100_1
(HUMAN PLASMINOGEN
KRINGLE 4)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 7 LYS A 284
ASP A 406
PHE A 280
ARG A 635
 None
 1.32A 2pk4A-1evlA:
undetectable		 2pk4A-1evlA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		4 / 8 LEU A 277
GLY A 516
GLN A 381
THR A 380
 None
TSB  A2002 (-3.3A)
TSB  A2002 (-3.2A)
None
 0.71A 2wd9B-1evlA:
undetectable		 2wd9B-1evlA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MIH_A_CUA358_0
(PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		3 / 3 HIS A 385
HIS A 511
MET A 509
 ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
 0.93A 3mihA-1evlA:
undetectable		 3mihA-1evlA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWM_B_017B402_1
(PROTEASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 628
GLY A 566
ALA A 565
VAL A 624
ILE A 625
 None
 1.00A 3pwmA-1evlA:
undetectable		 3pwmA-1evlA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 628
GLY A 566
ALA A 565
VAL A 624
ILE A 625
 None
 0.99A 4hlaA-1evlA:
undetectable		 4hlaA-1evlA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 11 LEU A 628
GLY A 566
ALA A 565
VAL A 624
ILE A 625
 None
 1.00A 4hlaB-1evlA:
undetectable		 4hlaB-1evlA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 LEU A 285
PHE A 358
MET A 518
GLY A 516
LEU A 515
 None
None
None
TSB  A2002 (-3.3A)
None
 1.23A 4j7xB-1evlA:
undetectable		 4j7xB-1evlA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		7 / 8 ARG A 363
ARG A 375
PHE A 379
GLN A 479
GLY A 481
THR A 482
ARG A 520
 TSB  A2002 (-2.7A)
None
TSB  A2002 (-3.6A)
TSB  A2002 (-3.6A)
None
TSB  A2002 (-4.3A)
TSB  A2002 (-3.9A)
 0.70A 4k87A-1evlA:
27.2		 4k87A-1evlA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_B_HFGB802_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 12 GLU A 365
PRO A 331
ARG A 363
HIS A 385
THR A 482
 TSB  A2002 (-3.7A)
None
TSB  A2002 (-2.7A)
ZN  A   1 ( 3.3A)
TSB  A2002 (-4.3A)
 1.40A 5xioB-1evlA:
27.5		 5xioB-1evlA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 ARG A 363
GLU A 365
PHE A 379
GLY A 516
ARG A 520
 TSB  A2002 (-2.7A)
TSB  A2002 (-3.7A)
TSB  A2002 (-3.6A)
TSB  A2002 (-3.3A)
TSB  A2002 (-3.9A)
 0.66A 6bniA-1evlA:
11.2		 6bniA-1evlA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 1evl THREONYL-TRNA
SYNTHETASE
(Escherichia
coli) 		5 / 10 ARG A 363
GLU A 365
PHE A 379
GLY A 516
ARG A 520
 TSB  A2002 (-2.7A)
TSB  A2002 (-3.7A)
TSB  A2002 (-3.6A)
TSB  A2002 (-3.3A)
TSB  A2002 (-3.9A)
 0.63A 6bniB-1evlA:
12.7		 6bniB-1evlA:
12.74