SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1evs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 1evs ONCOSTATIN M
(Homo
sapiens) 		5 / 12 PRO A  57
PHE A 176
THR A  21
ILE A 118
ALA A  76
 None
 1.00A 1fm4A-1evsA:
undetectable		 1fm4A-1evsA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 1evs ONCOSTATIN M
(Homo
sapiens) 		4 / 7 HIS A 178
SER A 179
ARG A 182
LEU A  62
 None
 1.16A 1ibgL-1evsA:
undetectable		 1ibgL-1evsA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1evs ONCOSTATIN M
(Homo
sapiens) 		3 / 3 LEU A  78
VAL A  81
LEU A  85
 None
 0.45A 1mz9B-1evsA:
undetectable		 1mz9B-1evsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1evs ONCOSTATIN M
(Homo
sapiens) 		4 / 7 PHE A  70
LEU A  14
GLU A  59
ARG A  63
 None
 0.94A 2jn3A-1evsA:
undetectable		 2jn3A-1evsA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 1evs ONCOSTATIN M
(Homo
sapiens) 		5 / 12 LEU A  17
THR A  21
LEU A  78
ASN A  75
ILE A 118
 None
 1.37A 2ydoA-1evsA:
2.2		 2ydoA-1evsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1evs ONCOSTATIN M
(Homo
sapiens) 		3 / 3 GLY A  69
GLY A  64
GLY A  66
 None
 0.35A 3bogC-1evsA:
0.0		 3bogC-1evsA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 1evs ONCOSTATIN M
(Homo
sapiens) 		4 / 5 LEU A  85
GLN A  90
LEU A  88
GLU A  89
 None
 1.08A 3h5gA-1evsA:
undetectable
3h5gB-1evsA:
undetectable		 3h5gA-1evsA:
11.56
3h5gB-1evsA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1evs ONCOSTATIN M
(Homo
sapiens) 		3 / 3 GLY A  66
TRP A 187
VAL A 183
 None
 0.53A 3n62B-1evsA:
0.0		 3n62B-1evsA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1evs ONCOSTATIN M
(Homo
sapiens) 		3 / 3 GLY A  66
TRP A 187
VAL A 183
 None
 0.52A 3n65B-1evsA:
0.1		 3n65B-1evsA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1evs ONCOSTATIN M
(Homo
sapiens) 		3 / 3 GLY A  66
TRP A 187
VAL A 183
 None
 0.52A 3n66B-1evsA:
1.8		 3n66B-1evsA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 1evs ONCOSTATIN M
(Homo
sapiens) 		3 / 3 GLU A  59
ARG A  63
GLN A  25
 None
 0.81A 4rtbA-1evsA:
undetectable		 4rtbA-1evsA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1evs ONCOSTATIN M
(Homo
sapiens) 		3 / 3 LEU A  30
LEU A  85
ARG A  52
 None
 0.49A 5hnzB-1evsA:
undetectable		 5hnzB-1evsA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 1evs ONCOSTATIN M
(Homo
sapiens) 		5 / 12 GLN A 112
ALA A 114
GLU A 106
LEU A 108
ILE A  37
 None
 1.31A 5vlmA-1evsA:
0.1		 5vlmA-1evsA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1evs ONCOSTATIN M
(Homo
sapiens) 		3 / 3 GLY A  66
TRP A 187
VAL A 183
 None
 0.54A 5vuoB-1evsA:
0.1		 5vuoB-1evsA:
18.44