SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ewk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 12 ASN A 365
ASP A  42
ILE A  46
GLY A 102
THR A 100
 None
 1.34A 1g60B-1ewkA:
2.4		 1g60B-1ewkA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		3 / 3 THR A 295
LEU A 299
LEU A 306
 None
 0.61A 1mz9C-1ewkA:
undetectable		 1mz9C-1ewkA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 7 ARG A 106
ILE A 105
LEU A  86
PHE A  83
TYR A 418
 None
 1.37A 1rtsB-1ewkA:
0.0		 1rtsB-1ewkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		4 / 7 LEU A 424
ILE A  47
ILE A  89
ASP A  44
 None
 0.72A 1uwjA-1ewkA:
undetectable		 1uwjA-1ewkA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W0G_A_MYTA1499_1
(CYTOCHROME P450 3A4)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		4 / 6 SER A 207
ILE A 190
ALA A 243
ALA A 214
 None
 0.98A 1w0gA-1ewkA:
0.0		 1w0gA-1ewkA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_B_EDTB1511_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		4 / 8 TYR A  74
ARG A  71
TYR A 236
THR A 188
 GLU  A 701 (-4.6A)
None
GLU  A 701 (-3.4A)
GLU  A 701 (-3.1A)
 1.45A 1zlqB-1ewkA:
0.8		 1zlqB-1ewkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 12 LEU A  96
GLY A 102
ASP A  87
ILE A 160
ILE A  89
 MG  A1001 (-4.8A)
None
None
None
None
 0.89A 2avvE-1ewkA:
undetectable		 2avvE-1ewkA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 11 LEU A  95
ASP A  87
GLY A  43
ALA A 421
ILE A  89
 None
 1.01A 2idwA-1ewkA:
undetectable		 2idwA-1ewkA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 9 LEU A  96
GLY A 102
ASP A  87
ILE A 160
ILE A  89
 MG  A1001 (-4.8A)
None
None
None
None
 0.96A 2idwB-1ewkA:
undetectable		 2idwB-1ewkA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		4 / 8 ILE A 417
ALA A 419
LEU A 454
ILE A 160
 None
 0.82A 2w9sE-1ewkA:
2.7		 2w9sE-1ewkA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		3 / 3 PRO A 162
LEU A  50
ARG A  36
 None
 0.76A 3aqiA-1ewkA:
4.2		 3aqiA-1ewkA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		4 / 7 GLY A 411
GLN A 406
VAL A 347
ILE A 417
 None
 0.91A 3fi0P-1ewkA:
undetectable		 3fi0P-1ewkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_A_THHA642_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 12 GLU A 292
GLY A 293
ASP A 318
VAL A 205
GLY A 163
 None
None
GLU  A 701 (-3.0A)
None
None
 1.12A 3k13A-1ewkA:
undetectable		 3k13A-1ewkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 12 GLU A 292
GLY A 293
ASP A 318
VAL A 205
GLY A 163
 None
None
GLU  A 701 (-3.0A)
None
None
 1.14A 3k13B-1ewkA:
undetectable		 3k13B-1ewkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 12 GLU A 292
GLY A 293
ASP A 318
VAL A 205
GLY A 163
 None
None
GLU  A 701 (-3.0A)
None
None
 1.15A 3k13C-1ewkA:
undetectable		 3k13C-1ewkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 12 LEU A  96
GLY A 102
ASP A  87
ILE A 160
ILE A  89
 MG  A1001 (-4.8A)
None
None
None
None
 0.82A 3nduA-1ewkA:
undetectable		 3nduA-1ewkA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		4 / 8 GLN A 425
ALA A 421
LEU A 424
LEU A 438
 None
 0.83A 3ozwA-1ewkA:
5.0		 3ozwA-1ewkA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 12 PHE A 244
GLN A 211
ALA A 212
ALA A 214
LEU A 253
 None
 1.10A 4j6dA-1ewkA:
0.0		 4j6dA-1ewkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 12 PHE A 244
GLN A 211
ALA A 212
ALA A 214
LEU A 253
 None
 1.11A 4j6dB-1ewkA:
0.0		 4j6dB-1ewkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 12 PHE A 244
GLN A 211
ALA A 212
ALA A 214
LEU A 253
 None
 1.08A 4jbtA-1ewkA:
0.0		 4jbtA-1ewkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 11 PHE A 244
GLN A 211
ALA A 212
ALA A 214
LEU A 253
 None
 1.07A 4jbtB-1ewkA:
0.0		 4jbtB-1ewkA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 9 ASP A 407
ALA A 184
GLY A  75
PHE A  51
GLY A 163
 None
 1.20A 4mmbA-1ewkA:
0.0		 4mmbA-1ewkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 9 ASP A 407
ALA A 184
GLY A  75
PHE A  51
GLY A 163
 None
 1.18A 4mmeB-1ewkA:
0.0		 4mmeB-1ewkA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 9 LEU A  86
GLY A  48
ALA A  49
ILE A 183
THR A  85
 None
 1.17A 4njtD-1ewkA:
undetectable		 4njtD-1ewkA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		4 / 5 GLY A 158
LEU A  86
ILE A 160
LEU A 438
 None
 0.84A 4o8fA-1ewkA:
0.0		 4o8fA-1ewkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		3 / 3 ASP A 351
LEU A 355
PHE A 354
 None
 0.73A 4pthA-1ewkA:
3.2		 4pthA-1ewkA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		4 / 4 PHE A 290
ASP A 318
GLY A 240
SER A 317
 None
GLU  A 701 (-3.0A)
None
None
 1.33A 4xp9C-1ewkA:
0.0		 4xp9C-1ewkA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		3 / 3 LYS A 341
LEU A 505
ILE A 338
 None
 0.76A 5kc0A-1ewkA:
0.0		 5kc0A-1ewkA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		4 / 8 TYR A  74
ARG A  71
TYR A 236
THR A 188
 GLU  A 701 (-4.6A)
None
GLU  A 701 (-3.4A)
GLU  A 701 (-3.1A)
 1.46A 5l8dA-1ewkA:
1.7		 5l8dA-1ewkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		4 / 7 LEU A 300
ILE A 340
THR A 339
MET A 215
 None
 1.40A 5ljcA-1ewkA:
0.0		 5ljcA-1ewkA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_A_EDTA609_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		4 / 8 TYR A  74
ARG A  71
TYR A 236
THR A 188
 GLU  A 701 (-4.6A)
None
GLU  A 701 (-3.4A)
GLU  A 701 (-3.1A)
 1.46A 5mwuA-1ewkA:
1.7		 5mwuA-1ewkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 12 LEU A 202
GLY A 158
LEU A  86
ILE A 160
LEU A 438
 None
 0.74A 5y2tA-1ewkA:
undetectable		 5y2tA-1ewkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 12 LEU A 202
GLY A 158
LEU A  86
ILE A 160
LEU A 438
 None
 0.82A 5ycnA-1ewkA:
0.0		 5ycnA-1ewkA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MB9_D_NMYD302_0
(AAC(3)-IIIB PROTEIN)		 1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1
(Rattus
norvegicus) 		5 / 10 ASP A 318
THR A 232
GLY A 240
ASP A 242
GLU A 238
 GLU  A 701 (-3.0A)
None
None
None
None
 1.41A 6mb9D-1ewkA:
0.0		 6mb9D-1ewkA:
9.41