SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ewr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 SER A 290
HIS A 173
ARG A 172
LEU A 166
 None
 0.93A 1ibgL-1ewrA:
0.0		 1ibgL-1ewrA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 PHE A 263
LEU A 601
VAL A 605
VAL A 262
THR A 256
 None
 1.19A 1q23B-1ewrA:
undetectable		 1q23B-1ewrA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_F_RTLF2_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 ALA A 675
LEU A 705
GLY A 665
PHE A 639
MET A 643
 None
 1.17A 1qabF-1ewrA:
0.0		 1qabF-1ewrA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 8 ASP A 277
PHE A 273
LEU A 292
THR A 271
 None
 0.99A 1rmtD-1ewrA:
undetectable		 1rmtD-1ewrA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 10 SER A 274
PHE A 273
LEU A 292
GLY A 284
ARG A 285
 None
 1.06A 2b8jB-1ewrA:
0.0		 2b8jB-1ewrA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 ALA A 715
GLY A 738
GLY A 583
ALA A 742
LEU A 747
 None
 1.09A 2plwA-1ewrA:
undetectable		 2plwA-1ewrA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 8 ARG A 756
LEU A 722
ALA A 742
ALA A 743
 None
 0.99A 3ns1L-1ewrA:
0.2		 3ns1L-1ewrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		3 / 3 LYS A 518
ARG A 518
ASP A 348
 None
 1.17A 3o7wA-1ewrA:
undetectable		 3o7wA-1ewrA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 VAL A 646
LEU A 650
PHE A 693
LEU A 578
 None
 1.06A 3qeoB-1ewrA:
2.3		 3qeoB-1ewrA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 HIS A 726
HIS A 558
ALA A 614
ASN A 570
LEU A 551
 None
 1.34A 3tm4A-1ewrA:
undetectable		 3tm4A-1ewrA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 ARG A 219
ALA A 138
TRP A 143
ALA A 181
 None
 0.99A 3tx2A-1ewrA:
1.7		 3tx2A-1ewrA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 ARG A 716
GLY A 738
TYR A 737
SER A 736
 None
 0.93A 4cp3A-1ewrA:
0.0
4cp3B-1ewrA:
0.0		 4cp3A-1ewrA:
11.74
4cp3B-1ewrA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		3 / 3 ASN A 710
LEU A 572
PHE A 693
 None
 0.78A 4dajB-1ewrA:
0.0		 4dajB-1ewrA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_B_NCTB501_1
(CYTOCHROME P450 2A6)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 7 VAL A 680
PHE A 639
GLY A 665
THR A 668
 None
 1.01A 4ejjB-1ewrA:
0.0		 4ejjB-1ewrA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 9 VAL A 728
VAL A 579
ILE A 581
GLY A 583
ALA A 587
 None
 1.11A 4fwdA-1ewrA:
3.2		 4fwdA-1ewrA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LMN_A_EUIA503_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		3 / 3 ASP A 662
VAL A 579
ASN A 585
 None
 0.78A 4lmnA-1ewrA:
0.0		 4lmnA-1ewrA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 5 THR A 582
THR A 678
LEU A 705
LEU A 708
 None
 1.09A 4lvcB-1ewrA:
undetectable		 4lvcB-1ewrA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 GLU A 169
PHE A 147
ARG A 242
HIS A 294
 None
 1.43A 4uciA-1ewrA:
0.0		 4uciA-1ewrA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 ARG A 172
GLY A 621
ARG A 687
LEU A 252
ILE A 649
 None
 1.06A 4uw0A-1ewrA:
undetectable		 4uw0A-1ewrA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 11 ALA A 228
ALA A 226
VAL A 150
GLY A 233
GLY A 234
 None
 0.95A 5lf7K-1ewrA:
undetectable
5lf7L-1ewrA:
undetectable		 5lf7K-1ewrA:
14.72
5lf7L-1ewrA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 11 ALA A 228
ALA A 226
VAL A 150
GLY A 233
GLY A 234
 None
 0.96A 5lf7Y-1ewrA:
undetectable
5lf7Z-1ewrA:
undetectable		 5lf7Y-1ewrA:
14.72
5lf7Z-1ewrA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		5 / 12 GLY A 731
ALA A 733
PHE A 698
TYR A 737
ALA A 714
 None
 1.12A 5n0oB-1ewrA:
2.4		 5n0oB-1ewrA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		3 / 3 ARG A 687
PHE A 693
LEU A 650
 None
 0.52A 5x1bC-1ewrA:
undetectable		 5x1bC-1ewrA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 1ewr DNA MISMATCH REPAIR
PROTEIN MUTS
(Thermus
aquaticus) 		4 / 6 GLN A 289
VAL A 529
LEU A 257
PRO A 295
 None
 1.07A 6brdB-1ewrA:
0.0		 6brdB-1ewrA:
8.78