SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ewx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 1ewx TRYPAREDOXIN I
(Crithidia
fasciculata) 		4 / 8 PHE A  33
LEU A   8
GLY A   3
ASP A   5
 None
None
ACE  A   1 (-4.2A)
None
 0.96A 1rmtC-1ewxA:
undetectable		 1rmtC-1ewxA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ewx TRYPAREDOXIN I
(Crithidia
fasciculata) 		5 / 12 VAL A 115
PHE A  35
PHE A  33
LEU A   8
THR A 124
 None
 1.24A 4eckA-1ewxA:
undetectable		 4eckA-1ewxA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 1ewx TRYPAREDOXIN I
(Crithidia
fasciculata) 		4 / 6 PHE A  32
THR A 124
ASP A 121
GLY A 120
 None
 1.12A 5mraA-1ewxA:
undetectable
5mraB-1ewxA:
0.0		 5mraA-1ewxA:
19.76
5mraB-1ewxA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 1ewx TRYPAREDOXIN I
(Crithidia
fasciculata) 		5 / 12 SER A 119
LEU A 112
PHE A  32
ASP A 116
ASP A 144
 None
 1.44A 6dwnB-1ewxA:
undetectable		 6dwnB-1ewxA:
20.13