SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ex0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		3 / 4 VAL A 431
TRP A 370
TRP A 375
 None
 1.38A 1gmkA-1ex0A:
undetectable
1gmkB-1ex0A:
undetectable		 1gmkA-1ex0A:
1.69
1gmkB-1ex0A:
1.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 8 VAL A 241
VAL A 316
VAL A 320
ILE A 234
 None
 0.92A 1igxA-1ex0A:
1.1		 1igxA-1ex0A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 10 ILE A 330
ALA A 192
ASP A 191
PHE A 184
ILE A 153
 None
 1.32A 1j3jA-1ex0A:
undetectable		 1j3jA-1ex0A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_0
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 PHE A 568
LEU A 553
ALA A 555
ILE A 589
LEU A 598
 None
 1.17A 1kglA-1ex0A:
0.0		 1kglA-1ex0A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_A_DVAA6_0
(GRAMICIDIN A)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		3 / 3 ALA A 318
VAL A 320
TRP A 225
 None
 0.89A 1nt5A-1ex0A:
undetectable		 1nt5A-1ex0A:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT5_B_DVAB6_0
(GRAMICIDIN A)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		3 / 3 ALA A 318
VAL A 320
TRP A 225
 None
 0.89A 1nt5B-1ex0A:
undetectable		 1nt5B-1ex0A:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		3 / 3 GLU A 377
TRP A 392
LYS A 504
 None
 1.32A 1qu2A-1ex0A:
undetectable		 1qu2A-1ex0A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 7 GLN A 468
PHE A 213
ARG A 333
ASN A 207
 None
 1.11A 1t9wA-1ex0A:
0.0		 1t9wA-1ex0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		3 / 3 VAL A 266
ASN A 376
TRP A 375
 None
 1.00A 2y00B-1ex0A:
undetectable		 2y00B-1ex0A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_0
(UNCHARACTERIZED
PROTEIN MJ1557)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 ASN A 337
GLY A 215
TYR A 338
TYR A 560
PHE A 559
 None
 1.40A 3a27A-1ex0A:
undetectable		 3a27A-1ex0A:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 5 THR A 625
PHE A 606
PHE A 568
TYR A 594
 None
 1.32A 3em0A-1ex0A:
0.2		 3em0A-1ex0A:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 5 TYR A 181
THR A 180
PHE A 157
ARG A 158
 None
 1.45A 3qelC-1ex0A:
undetectable		 3qelC-1ex0A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 10 ILE A 330
ALA A 192
ASP A 191
PHE A 184
ILE A 153
 None
 1.38A 3qg2A-1ex0A:
undetectable		 3qg2A-1ex0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 6 SER A 263
ALA A 264
ARG A 260
LEU A 325
 None
None
PGO  A1340 (-4.3A)
None
 0.85A 3ravA-1ex0A:
undetectable		 3ravA-1ex0A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 GLY A 410
ALA A 412
PHE A 430
CYH A 314
CYH A 374
 None
 1.18A 3s8pA-1ex0A:
undetectable		 3s8pA-1ex0A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 GLY A 410
ALA A 412
PHE A 430
CYH A 314
CYH A 374
 None
 1.18A 3s8pB-1ex0A:
0.0		 3s8pB-1ex0A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 5 LEU A 385
ARG A 382
PRO A 411
ALA A 412
 None
 1.41A 3vm4A-1ex0A:
0.0		 3vm4A-1ex0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 GLY A 410
ALA A 412
PHE A 430
CYH A 314
CYH A 374
 None
 1.19A 4bupB-1ex0A:
undetectable		 4bupB-1ex0A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 7 GLU A 377
ARG A 326
ARG A 333
LYS A 467
 None
 1.05A 4fgzA-1ex0A:
undetectable		 4fgzA-1ex0A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 8 ASN A 454
LEU A 619
ASP A 617
ILE A 612
 None
 0.92A 4k0bA-1ex0A:
0.0		 4k0bA-1ex0A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 7 GLY A 473
ASP A 472
GLY A 470
GLU A 203
 None
 0.75A 4koeA-1ex0A:
undetectable
4koeB-1ex0A:
undetectable
4koeD-1ex0A:
undetectable		 4koeA-1ex0A:
21.26
4koeB-1ex0A:
21.26
4koeD-1ex0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 7 ILE A 612
ARG A 611
ILE A 549
ALA A 610
 None
 0.95A 4lv9B-1ex0A:
undetectable		 4lv9B-1ex0A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 7 THR A 558
PHE A 606
SER A 624
HIS A 605
 None
 1.45A 4o4dA-1ex0A:
0.0		 4o4dA-1ex0A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 ALA A 192
ARG A  78
GLY A 253
GLY A 329
PHE A 184
 None
 1.12A 4r29A-1ex0A:
0.0		 4r29A-1ex0A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 ALA A 192
ARG A  78
GLY A 253
GLY A 329
PHE A 184
 None
 1.11A 4r29B-1ex0A:
0.0		 4r29B-1ex0A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 ALA A 192
ARG A  78
GLY A 253
GLY A 329
PHE A 184
 None
 1.10A 4r29C-1ex0A:
0.0		 4r29C-1ex0A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 ALA A 192
ARG A  78
GLY A 253
GLY A 329
PHE A 184
 None
 1.11A 4r29D-1ex0A:
0.0		 4r29D-1ex0A:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		3 / 3 ARG A 244
GLN A 246
GLU A 272
 None
 0.79A 4tvtA-1ex0A:
0.7		 4tvtA-1ex0A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 6 ASN A 337
ASP A 396
THR A 480
THR A 478
 None
 1.10A 4yoaA-1ex0A:
undetectable		 4yoaA-1ex0A:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 7 GLY A 473
ASP A 472
GLY A 470
GLU A 203
 None
 0.86A 4z53A-1ex0A:
undetectable
4z53B-1ex0A:
undetectable		 4z53A-1ex0A:
23.87
4z53B-1ex0A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 GLY A 410
ALA A 412
PHE A 430
CYH A 314
CYH A 374
 None
 1.10A 5cprB-1ex0A:
undetectable		 5cprB-1ex0A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		3 / 3 LEU A 598
LEU A 529
ARG A 661
 None
 0.64A 5hnzB-1ex0A:
undetectable		 5hnzB-1ex0A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U6M_B_SALB503_1
(UDP-GLYCOSYLTRANSFER
ASE 74F2)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 7 THR A 558
HIS A 605
PHE A 607
THR A 365
 None
 1.28A 5u6mB-1ex0A:
undetectable		 5u6mB-1ex0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 GLY A 410
ALA A 412
PHE A 430
CYH A 314
CYH A 374
 None
 1.20A 5wbvA-1ex0A:
0.0		 5wbvA-1ex0A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 GLY A 410
ALA A 412
PHE A 430
CYH A 314
CYH A 374
 None
 1.22A 5wbvB-1ex0A:
0.0		 5wbvB-1ex0A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		5 / 12 THR A 688
GLN A 690
THR A 649
VAL A 648
VAL A 665
 None
 1.20A 6bzoC-1ex0A:
0.0		 6bzoC-1ex0A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB503_0
(AMINE OXIDASE LKCE)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		3 / 3 VAL A 452
GLU A 453
ILE A 440
 None
 0.65A 6f7lB-1ex0A:
undetectable		 6f7lB-1ex0A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_B_IXXB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 1ex0 COAGULATION FACTOR
XIII A CHAIN
(Homo
sapiens) 		4 / 5 ARG A 715
ALA A 291
TYR A 718
GLN A 313
 None
 1.46A 6g9bA-1ex0A:
0.0
6g9bB-1ex0A:
0.0		 6g9bA-1ex0A:
7.79
6g9bB-1ex0A:
8.39