SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ex6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 1ex6 GUANYLATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  21
LEU A  17
LEU A 171
ARG A 131
LEU A 118
 None
 1.47A 2w8yB-1ex6A:
undetectable		 2w8yB-1ex6A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 1ex6 GUANYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 6 VAL A   5
ASP A 100
LYS A 105
TYR A 156
 None
 1.29A 2zs9A-1ex6A:
5.3		 2zs9A-1ex6A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 1ex6 GUANYLATE KINASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  21
LEU A  17
LEU A 171
ARG A 131
LEU A 118
 None
 1.43A 3d90A-1ex6A:
undetectable		 3d90A-1ex6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_2
(GAG-POL POLYPROTEIN)		 1ex6 GUANYLATE KINASE
(Saccharomyces
cerevisiae) 		6 / 12 ALA A 174
ASP A 170
ASP A 169
VAL A 167
GLY A  13
ILE A 166
 None
 1.42A 3jw2B-1ex6A:
undetectable		 3jw2B-1ex6A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 1ex6 GUANYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 6 PHE A  58
PHE A  67
THR A  36
VAL A  53
 None
 1.31A 3lb3A-1ex6A:
undetectable		 3lb3A-1ex6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1ex6 GUANYLATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 130
ASN A 144
ASP A 127
 None
 0.83A 4o1eA-1ex6A:
undetectable		 4o1eA-1ex6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 1ex6 GUANYLATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A   8
PRO A   9
ALA A 149
 None
 0.54A 4qn9B-1ex6A:
0.0		 4qn9B-1ex6A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1ex6 GUANYLATE KINASE
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 178
PHE A 181
LEU A  18
PHE A  22
 None
 1.17A 5x1fC-1ex6A:
undetectable
5x1fJ-1ex6A:
0.0		 5x1fC-1ex6A:
20.45
5x1fJ-1ex6A:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1ex6 GUANYLATE KINASE
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 146
ILE A 143
SER A 142
 None
 0.88A 5zw2A-1ex6A:
0.0		 5zw2A-1ex6A:
21.16