SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1exb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 11 SER A 319
MET A 241
LEU A 321
VAL A 114
ILE A  81
 None
None
NDP  A1000 (-4.0A)
None
None
 1.26A 1ee2A-1exbA:
undetectable		 1ee2A-1exbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 11 SER A 319
MET A 241
LEU A 321
VAL A 114
ILE A  81
 None
None
NDP  A1000 (-4.0A)
None
None
 1.25A 1ee2B-1exbA:
undetectable		 1ee2B-1exbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 TYR A 151
LEU A 147
LEU A 144
LEU A 113
ILE A 115
 None
 1.37A 1fmlA-1exbA:
0.5		 1fmlA-1exbA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HA2_A_SWFA3001_1
(SERUM ALBUMIN)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 11 ALA A  76
LEU A 330
LEU A  54
ILE A  64
ALA A  69
 None
 1.06A 1ha2A-1exbA:
undetectable		 1ha2A-1exbA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 GLY A 323
LEU A 246
ILE A 308
ILE A  81
LEU A  52
 NDP  A1000 (-3.6A)
NDP  A1000 (-4.0A)
None
None
None
 1.02A 1kyvA-1exbA:
undetectable
1kyvE-1exbA:
undetectable		 1kyvA-1exbA:
19.22
1kyvE-1exbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 ILE A  81
LEU A  52
GLY A 323
LEU A 246
ILE A 308
 None
None
NDP  A1000 (-3.6A)
NDP  A1000 (-4.0A)
None
 1.00A 1kyvB-1exbA:
undetectable
1kyvC-1exbA:
undetectable		 1kyvB-1exbA:
19.22
1kyvC-1exbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 ILE A  81
LEU A  52
GLY A 323
LEU A 246
ILE A 308
 None
None
NDP  A1000 (-3.6A)
NDP  A1000 (-4.0A)
None
 1.04A 1kyvC-1exbA:
undetectable
1kyvD-1exbA:
undetectable		 1kyvC-1exbA:
19.22
1kyvD-1exbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 ILE A  81
LEU A  52
GLY A 323
LEU A 246
ILE A 308
 None
None
NDP  A1000 (-3.6A)
NDP  A1000 (-4.0A)
None
 1.04A 1kyvD-1exbA:
undetectable
1kyvE-1exbA:
undetectable		 1kyvD-1exbA:
19.22
1kyvE-1exbA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		4 / 7 VAL A 114
LEU A  47
ILE A  81
ASN A  82
 None
 1.02A 3avpA-1exbA:
0.0		 3avpA-1exbA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 ARG A 264
GLY A  55
GLY A 323
THR A  56
LEU A  99
 NDP  A1000 (-2.9A)
NDP  A1000 (-2.7A)
NDP  A1000 (-3.6A)
None
None
 1.10A 3dh0B-1exbA:
undetectable		 3dh0B-1exbA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 PHE A  60
TYR A 270
GLY A  62
HIS A  71
ARG A 264
 None
None
None
None
NDP  A1000 (-2.9A)
 1.26A 3dlcA-1exbA:
undetectable		 3dlcA-1exbA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 LEU A  52
GLY A  53
LEU A 322
ILE A 334
ALA A 324
 None
None
None
None
NDP  A1000 ( 4.9A)
 1.02A 3gwvA-1exbA:
0.0		 3gwvA-1exbA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 LEU A  52
GLY A  53
LEU A 322
ILE A 334
ALA A 324
 None
None
None
None
NDP  A1000 ( 4.9A)
 0.94A 3gwwA-1exbA:
0.0		 3gwwA-1exbA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		3 / 3 TRP A  57
ALA A  95
VAL A  58
 NDP  A1000 (-4.4A)
None
None
 0.98A 3l8lA-1exbA:
undetectable
3l8lB-1exbA:
undetectable		 3l8lA-1exbA:
4.18
3l8lB-1exbA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		4 / 8 THR A  86
LEU A 149
LEU A 147
GLY A 100
 None
 0.77A 4c9nA-1exbA:
0.0		 4c9nA-1exbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_2
(ADENOSINE KINASE)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		4 / 4 LEU A 321
ILE A  81
GLY A  55
PHE A  84
 NDP  A1000 (-4.0A)
None
NDP  A1000 (-2.7A)
None
 0.75A 4dc3A-1exbA:
3.2		 4dc3A-1exbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 LEU A 340
LEU A 303
LEU A 343
ILE A 354
LEU A 355
 None
 1.04A 5ienB-1exbA:
undetectable		 5ienB-1exbA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 GLY A 335
MET A 331
ASN A 333
LEU A 330
ALA A  76
 None
None
NDP  A1000 (-3.1A)
None
None
 1.33A 5kbwA-1exbA:
undetectable		 5kbwA-1exbA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 GLY A 335
MET A 331
ASN A 333
ALA A  76
ASN A  79
 None
None
NDP  A1000 (-3.1A)
None
None
 1.37A 5kc0A-1exbA:
0.0		 5kc0A-1exbA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1exb KV BETA2 PROTEIN
(Rattus
norvegicus) 		5 / 12 GLY A 335
MET A 331
ASN A 333
ALA A  76
ASN A  79
 None
None
NDP  A1000 (-3.1A)
None
None
 1.49A 5kc4A-1exbA:
undetectable		 5kc4A-1exbA:
18.75