SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1exf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		4 / 6 LEU A 181
GLY A 228
HIS A 213
ILE A 199
 None
 0.80A 1xf1B-1exfA:
undetectable		 1xf1B-1exfA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		4 / 7 TYR A 183
TYR A 184
HIS A 219
TRP A   3
 None
 1.30A 1yvmA-1exfA:
undetectable		 1yvmA-1exfA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_C_8MOC501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		5 / 10 PHE A 200
ILE A 139
GLY A 140
THR A  43
ILE A 212
 None
 1.12A 1z11C-1exfA:
undetectable		 1z11C-1exfA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		4 / 8 LEU A 138
ILE A 160
ILE A 212
HIS A 213
 None
 0.90A 2azxA-1exfA:
undetectable		 2azxA-1exfA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		4 / 8 ASN A 194
SER A 197
ASP A 144
SER A  41
 None
 1.03A 2zw9B-1exfA:
undetectable		 2zw9B-1exfA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		4 / 8 ASN A 153
ILE A  70
PHE A  66
TYR A 141
 None
 1.45A 3ccfB-1exfA:
undetectable		 3ccfB-1exfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		3 / 3 GLU A   1
HIS A 223
HIS A 219
 None
 0.70A 3co4A-1exfA:
undetectable		 3co4A-1exfA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		5 / 10 ILE A 238
ILE A 231
VAL A 210
GLY A 198
PRO A  26
 None
 1.20A 3elzC-1exfA:
0.0		 3elzC-1exfA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		5 / 12 HIS A  57
ASP A 102
ARG A 182
GLY A 193
SER A 195
 None
 0.85A 3sueB-1exfA:
10.8		 3sueB-1exfA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		4 / 5 PHE A 200
ILE A 139
GLY A 140
THR A  43
 None
 1.03A 4ejjC-1exfA:
0.0		 4ejjC-1exfA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		5 / 12 PHE A  66
GLU A  78
GLN A  26
ILE A 118
LEU A  46
 None
 1.40A 4k38B-1exfA:
undetectable		 4k38B-1exfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		5 / 8 THR A  43
LEU A 138
VAL A 210
LEU A 209
GLY A  44
 None
 1.30A 4r3aA-1exfA:
undetectable		 4r3aA-1exfA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		6 / 11 LEU A 130
LEU A 165
LEU A 103
LEU A 209
ILE A 199
LEU A  53
 None
 1.43A 4zowA-1exfA:
undetectable		 4zowA-1exfA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		3 / 3 LEU A 181
THR A 190
ASN A 194
 None
 0.72A 6baaE-1exfA:
0.0		 6baaE-1exfA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		3 / 3 LEU A 181
THR A 190
ASN A 194
 None
 0.72A 6baaF-1exfA:
0.0		 6baaF-1exfA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		3 / 3 LEU A 181
THR A 190
ASN A 194
 None
 0.73A 6baaG-1exfA:
undetectable		 6baaG-1exfA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		3 / 3 LEU A 181
THR A 190
ASN A 194
 None
 0.73A 6baaH-1exfA:
0.0		 6baaH-1exfA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		5 / 12 HIS A  57
ASP A 102
ARG A 182
GLY A 193
SER A 195
 None
 0.82A 6c2mC-1exfA:
10.5		 6c2mC-1exfA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1exf EXFOLIATVE TOXIN A
(Staphylococcus
aureus) 		3 / 3 TRP A   3
ILE A 225
GLU A 161
 None
 0.70A 6hcxA-1exfA:
undetectable		 6hcxA-1exfA:
16.39