SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1exx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		4 / 5 THR A 399
THR A 308
HIS A 300
LEU A 222
 None
 1.06A 1d4fC-1exxA:
undetectable		 1d4fC-1exxA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HO5_A_ADNA1604_1
(5'-NUCLEOTIDASE)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		5 / 11 ILE A 383
SER A 390
GLY A 388
PHE A 314
ASP A 269
 None
 1.38A 1ho5A-1exxA:
undetectable		 1ho5A-1exxA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		5 / 11 LEU A 307
ALA A 315
MET A 272
MET A 286
LEU A 268
 961  A 450 (-4.8A)
None
961  A 450 (-3.1A)
None
961  A 450 ( 4.9A)
 1.27A 1iiuA-1exxA:
0.0		 1iiuA-1exxA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT6_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		5 / 11 LEU A 307
ALA A 315
MET A 272
MET A 286
LEU A 268
 961  A 450 (-4.8A)
None
961  A 450 (-3.1A)
None
961  A 450 ( 4.9A)
 1.29A 1kt6A-1exxA:
0.0		 1kt6A-1exxA:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		9 / 12 PHE A 230
ALA A 234
CYH A 237
LEU A 268
LEU A 271
ILE A 275
ARG A 278
SER A 289
PHE A 304
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 ( 4.9A)
961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
 0.54A 1xdkB-1exxA:
37.3		 1xdkB-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		5 / 12 PHE A 230
ALA A 234
CYH A 237
PHE A 304
LEU A 268
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-3.6A)
961  A 450 ( 4.9A)
 1.13A 1xdkB-1exxA:
37.3		 1xdkB-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		7 / 12 PHE A 230
ALA A 234
ILE A 275
ARG A 278
SER A 289
PHE A 304
LEU A 307
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
 0.55A 1xdkB-1exxA:
37.3		 1xdkB-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		5 / 12 PHE A 230
ALA A 234
PHE A 304
LEU A 307
LEU A 268
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
961  A 450 ( 4.9A)
 1.02A 1xdkB-1exxA:
37.3		 1xdkB-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		3 / 3 LEU A 233
PHE A 288
ARG A 396
 961  A 450 ( 4.0A)
961  A 450 (-4.6A)
None
 0.44A 1xdkB-1exxA:
37.3		 1xdkB-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		8 / 12 PHE A 230
ALA A 234
CYH A 237
ILE A 275
ARG A 278
SER A 289
PHE A 304
LEU A 307
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
 0.59A 1xdkF-1exxA:
37.3		 1xdkF-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		9 / 12 PHE A 230
ALA A 234
CYH A 237
LEU A 268
LEU A 271
ILE A 275
ARG A 278
SER A 289
PHE A 304
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 ( 4.9A)
961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
 0.53A 1xdkF-1exxA:
37.3		 1xdkF-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		7 / 12 PHE A 230
ALA A 234
CYH A 237
SER A 289
PHE A 304
LEU A 307
LEU A 268
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
961  A 450 ( 4.9A)
 1.22A 1xdkF-1exxA:
37.3		 1xdkF-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		3 / 3 LEU A 233
PHE A 288
ARG A 396
 961  A 450 ( 4.0A)
961  A 450 (-4.6A)
None
 0.45A 1xdkF-1exxA:
37.3		 1xdkF-1exxA:
81.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		12 / 12 PHE A 230
LYS A 236
CYH A 237
LEU A 271
MET A 272
ARG A 274
ILE A 275
ARG A 278
PHE A 288
SER A 289
GLY A 393
LEU A 400
 961  A 450 (-3.9A)
LMU  A 451 ( 3.7A)
961  A 450 (-3.6A)
961  A 450 (-3.6A)
961  A 450 (-3.1A)
None
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-4.6A)
961  A 450 (-2.5A)
961  A 450 ( 4.0A)
None
 0.42A 2lbdA-1exxA:
40.6		 2lbdA-1exxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		9 / 11 PHE A 230
CYH A 237
LEU A 271
ILE A 275
ARG A 278
PHE A 288
SER A 289
PHE A 304
LEU A 400
 961  A 450 (-3.9A)
961  A 450 (-3.6A)
961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-4.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
None
 0.49A 3a9eB-1exxA:
37.9		 3a9eB-1exxA:
77.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		5 / 12 LEU A 271
ILE A 275
ARG A 278
SER A 289
ALA A 394
 961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
None
 0.98A 3lbdA-1exxA:
40.5		 3lbdA-1exxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		12 / 12 PHE A 230
ALA A 234
LEU A 268
LEU A 271
MET A 272
ILE A 275
ARG A 278
SER A 289
PHE A 304
GLY A 393
ALA A 397
ILE A 412
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 ( 4.9A)
961  A 450 (-3.6A)
961  A 450 (-3.1A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 ( 4.0A)
961  A 450 ( 4.2A)
961  A 450 ( 4.1A)
 0.48A 3lbdA-1exxA:
40.5		 3lbdA-1exxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		10 / 11 PHE A 230
CYH A 237
LEU A 268
LEU A 271
ARG A 278
PHE A 288
SER A 289
LEU A 307
LEU A 400
ILE A 412
 961  A 450 (-3.9A)
961  A 450 (-3.6A)
961  A 450 ( 4.9A)
961  A 450 (-3.6A)
961  A 450 (-3.6A)
961  A 450 (-4.6A)
961  A 450 (-2.5A)
961  A 450 (-4.8A)
None
961  A 450 ( 4.1A)
 0.64A 4dm8A-1exxA:
38.4		 4dm8A-1exxA:
79.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		11 / 12 PHE A 201
PHE A 230
LEU A 233
ALA A 234
LEU A 268
LEU A 271
ARG A 278
SER A 289
PHE A 304
GLY A 393
LEU A 400
 961  A 450 (-4.5A)
961  A 450 (-3.9A)
961  A 450 ( 4.0A)
961  A 450 (-3.1A)
961  A 450 ( 4.9A)
961  A 450 (-3.6A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 ( 4.0A)
None
 0.53A 4dm8B-1exxA:
38.6		 4dm8B-1exxA:
79.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		3 / 3 MET A 323
GLU A 327
LEU A 331
 None
 0.48A 4v2oB-1exxA:
1.2		 4v2oB-1exxA:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		12 / 12 TRP A 227
PHE A 230
ALA A 234
LEU A 271
MET A 272
ILE A 275
ARG A 278
SER A 289
PHE A 304
GLY A 393
LEU A 400
ILE A 412
 None
961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 (-3.1A)
961  A 450 (-3.5A)
961  A 450 (-3.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 ( 4.0A)
None
961  A 450 ( 4.1A)
 0.50A 5m24A-1exxA:
41.0		 5m24A-1exxA:
99.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		9 / 12 PHE A 230
ALA A 234
CYH A 237
LEU A 268
LEU A 271
ILE A 275
PHE A 288
SER A 289
PHE A 304
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.6A)
961  A 450 ( 4.9A)
961  A 450 (-3.6A)
961  A 450 (-3.5A)
961  A 450 (-4.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
 0.52A 5uanB-1exxA:
37.6		 5uanB-1exxA:
72.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		7 / 12 PHE A 230
ALA A 234
ILE A 275
PHE A 288
SER A 289
PHE A 304
LEU A 307
 961  A 450 (-3.9A)
961  A 450 (-3.1A)
961  A 450 (-3.5A)
961  A 450 (-4.6A)
961  A 450 (-2.5A)
961  A 450 (-3.6A)
961  A 450 (-4.8A)
 0.57A 5uanB-1exxA:
37.6		 5uanB-1exxA:
72.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		5 / 7 LEU A 268
PHE A 288
LEU A 294
LEU A 307
GLY A 393
 961  A 450 ( 4.9A)
961  A 450 (-4.6A)
None
961  A 450 (-4.8A)
961  A 450 ( 4.0A)
 0.60A 6eu9D-1exxA:
28.9		 6eu9D-1exxA:
43.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 1exx RETINOIC ACID
RECEPTOR GAMMA-2
(Homo
sapiens) 		4 / 5 THR A 399
THR A 308
HIS A 300
LEU A 222
 None
 1.04A 6gbnB-1exxA:
undetectable		 6gbnB-1exxA:
20.32