SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ey2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 VAL A 266
ALA A 267
HIS A 269
 None
 0.69A 1q23C-1ey2A:
0.0		 1q23C-1ey2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 VAL A 266
ALA A 267
HIS A 269
 None
 0.71A 1q23H-1ey2A:
0.0		 1q23H-1ey2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 VAL A 266
ALA A 267
HIS A 269
 None
 0.69A 1q23G-1ey2A:
0.0		 1q23G-1ey2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 VAL A 266
ALA A 267
HIS A 269
 None
 0.73A 1q23L-1ey2A:
0.0		 1q23L-1ey2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 VAL A 266
ALA A 267
HIS A 269
 None
 0.70A 1q23J-1ey2A:
0.0		 1q23J-1ey2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 TRP A 411
PHE A 100
TRP A  97
 None
 1.48A 1r15C-1ey2A:
undetectable		 1r15C-1ey2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 TRP A 411
PHE A 100
TRP A  97
 None
 1.48A 1r15F-1ey2A:
undetectable		 1r15F-1ey2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 TRP A 411
PHE A 100
TRP A  97
 None
 1.47A 1r15G-1ey2A:
undetectable		 1r15G-1ey2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 TRP A 411
PHE A 100
TRP A  97
 None
 1.48A 1r15H-1ey2A:
0.0		 1r15H-1ey2A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		4 / 7 LEU A 364
THR A 118
LEU A  95
SER A 416
 None
 0.91A 1tyrB-1ey2A:
0.0		 1tyrB-1ey2A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		5 / 12 LEU A 301
THR A 302
LEU A 131
LEU A 201
ILE A 317
 None
 1.00A 2ouzA-1ey2A:
undetectable		 2ouzA-1ey2A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		4 / 7 PHE A 154
ILE A 156
ILE A 190
GLY A 185
 None
 0.95A 2v0mB-1ey2A:
undetectable		 2v0mB-1ey2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 GLU A  78
HIS A 117
HIS A 134
 None
 0.77A 3co4A-1ey2A:
undetectable		 3co4A-1ey2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 GLU A 401
HIS A 365
HIS A 335
 None
None
FE2  A1001 (-3.4A)
 0.79A 3co4A-1ey2A:
undetectable		 3co4A-1ey2A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3004_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		4 / 5 ILE A 133
PHE A 400
ASP A 314
GLU A 401
 None
 1.18A 3kp6A-1ey2A:
undetectable
3kp6B-1ey2A:
undetectable		 3kp6A-1ey2A:
16.13
3kp6B-1ey2A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_2
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 SER A 340
SER A 366
HIS A 335
 None
None
FE2  A1001 (-3.4A)
 0.85A 3mzeA-1ey2A:
0.1		 3mzeA-1ey2A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		5 / 12 TYR A 199
PHE A 357
SER A 363
ALA A 397
PHE A 318
 None
 1.37A 3nhxA-1ey2A:
undetectable		 3nhxA-1ey2A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		4 / 7 HIS A 335
GLU A 341
HIS A 371
GLU A 401
 FE2  A1001 (-3.4A)
FE2  A1001 (-2.2A)
FE2  A1001 (-3.5A)
None
 0.89A 4hvrA-1ey2A:
5.3		 4hvrA-1ey2A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IMA_D_ADND604_1
(PYRUVATE KINASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 ARG A  63
GLU A 168
ASN A 264
 None
 0.92A 4imaD-1ey2A:
undetectable		 4imaD-1ey2A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 LEU A  39
ARG A  63
MET A 186
 None
 0.93A 4m11C-1ey2A:
undetectable		 4m11C-1ey2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_C_Y70C151_1
(CEREBLON ISOFORM 4)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		4 / 8 ASN A 247
PHE A  73
PHE A 147
TYR A 243
 None
 1.39A 4v2zC-1ey2A:
0.0		 4v2zC-1ey2A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YFB_I_PACI601_0
(PROTEIN RELATED TO
PENICILLIN ACYLASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		5 / 12 PHE A 112
PHE A 147
ILE A 200
HIS A 134
VAL A  81
 None
 1.47A 4yfbI-1ey2A:
0.0		 4yfbI-1ey2A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		4 / 7 THR A  55
PRO A  52
THR A  50
SER A  47
 None
 1.35A 5b6iA-1ey2A:
undetectable		 5b6iA-1ey2A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		3 / 3 ILE A 229
PRO A 230
ILE A   7
 None
 0.36A 5hw8F-1ey2A:
undetectable		 5hw8F-1ey2A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		6 / 11 LEU A 201
GLU A 209
LEU A 131
VAL A 206
THR A 302
ALA A 313
 None
 1.45A 5o96A-1ey2A:
undetectable
5o96B-1ey2A:
undetectable		 5o96A-1ey2A:
22.88
5o96B-1ey2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1ey2 HOMOGENTISATE
1,2-DIOXYGENASE
(Homo
sapiens) 		5 / 12 VAL A  81
THR A 118
ALA A 132
PHE A 154
ASN A 149
 None
 1.25A 6drxA-1ey2A:
undetectable		 6drxA-1ey2A:
19.27