SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 11 LEU L 246
ALA L 245
ILE L 237
HIS L 198
LEU L 195
 None
BPH  L 606 ( 4.9A)
None
None
None
 1.26A 1g50A-1eysL:
undetectable		 1g50A-1eysL:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		3 / 3 ASP C  97
VAL C 268
PRO C 264
 None
 0.75A 2avvA-1eysC:
0.0		 2avvA-1eysC:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 6 ALA L 101
TYR L 156
ILE L  99
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
None
None
 0.96A 2dcfA-1eysL:
0.0		 2dcfA-1eysL:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 6 ALA L 101
TYR L 156
TYR L 136
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
BCL  L 604 ( 4.4A)
None
 1.28A 2dcfA-1eysL:
0.0		 2dcfA-1eysL:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 6 LEU L 139
ASN L 178
GLN L 171
PHE L 154
 BCL  L 602 (-4.4A)
None
None
BCL  L 604 (-3.5A)
 1.21A 2jn3A-1eysL:
0.0		 2jn3A-1eysL:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 8 ALA L 248
GLY L 134
SER L 252
ALA L 253
 None
None
BCL  L 602 (-3.2A)
BCL  L 602 ( 4.9A)
 0.79A 2vh3B-1eysL:
0.0		 2vh3B-1eysL:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 7 ALA L 101
TYR L 156
ILE L  99
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
None
None
 0.95A 2zm7A-1eysL:
undetectable		 2zm7A-1eysL:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 8 ALA L 101
TYR L 156
ILE L  99
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
None
None
 0.95A 2zm8A-1eysL:
undetectable		 2zm8A-1eysL:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 8 ALA L 101
TYR L 156
ILE L  99
ILE L  97
 BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
None
None
 0.96A 2zmaA-1eysL:
0.0		 2zmaA-1eysL:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum;
Thermochromatium
tepidum) 		5 / 12 GLY C  17
GLY L 151
GLY C  15
TRP L 164
LEU L  83
 None
 0.83A 3elwA-1eysC:
undetectable		 3elwA-1eysC:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum;
Thermochromatium
tepidum) 		5 / 12 GLY C  17
GLY L 151
GLY C  15
TRP L 164
LEU L  83
 None
 0.92A 3embA-1eysC:
undetectable		 3embA-1eysC:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		3 / 3 TYR C  22
TYR C 297
ILE C  31
 None
 0.57A 3eteA-1eysC:
undetectable
3eteB-1eysC:
undetectable		 3eteA-1eysC:
20.63
3eteB-1eysC:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		3 / 3 MET C 108
CYH C 288
PRO C 140
 HEM  C 610 (-1.9A)
HEM  C 612 (-1.7A)
HEM  C 610 ( 4.8A)
 1.21A 3h52C-1eysC:
undetectable		 3h52C-1eysC:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 10 ARG C 107
ILE C 262
ASN C 266
LEU C 269
VAL C 268
 None
HEM  C 610 ( 4.9A)
None
HEM  C 610 (-4.7A)
None
 1.23A 3o02A-1eysC:
undetectable
3o02B-1eysC:
undetectable		 3o02A-1eysC:
21.36
3o02B-1eysC:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 5 ILE C 217
GLY C 224
CYH C 228
HIS C 229
 HEM  C 612 (-4.2A)
None
HEM  C 611 (-1.7A)
HEM  C 611 (-3.6A)
 1.22A 3r0lD-1eysC:
undetectable		 3r0lD-1eysC:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 11 PHE L  34
GLY L  38
SER L 107
ALA L 102
ALA L 101
 None
None
None
None
BPH  L 606 ( 3.9A)
 1.19A 3sufC-1eysL:
undetectable		 3sufC-1eysL:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_D_ESTD600_1
(ESTROGEN RECEPTOR
BETA)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 12 LEU L 246
ALA L 245
ILE L 237
HIS L 198
LEU L 195
 None
BPH  L 606 ( 4.9A)
None
None
None
 1.23A 4j24D-1eysL:
undetectable		 4j24D-1eysL:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		3 / 3 SER L 166
ASP L 163
GLN C 239
 BCL  L 602 ( 4.3A)
None
None
 0.92A 4oltA-1eysL:
1.7
4oltB-1eysL:
0.5		 4oltA-1eysL:
23.02
4oltB-1eysL:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 11 LEU L 246
ALA L 245
ILE L 237
HIS L 198
LEU L 195
 None
BPH  L 606 ( 4.9A)
None
None
None
 1.20A 4pxmB-1eysL:
0.3		 4pxmB-1eysL:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		3 / 3 GLN C 239
SER L 166
ASP L 163
 None
BCL  L 602 ( 4.3A)
None
 0.89A 4qwpA-1eysC:
0.0
4qwpB-1eysC:
0.0		 4qwpA-1eysC:
22.03
4qwpB-1eysC:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 8 ALA L 104
ALA L 101
ALA L 132
TYR L 136
LEU L 137
 BPH  L 606 ( 4.1A)
BPH  L 606 ( 3.9A)
BPH  L 606 (-3.7A)
BCL  L 604 ( 4.4A)
None
 1.46A 4v1fA-1eysL:
2.7
4v1fB-1eysL:
2.8		 4v1fA-1eysL:
16.07
4v1fB-1eysL:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 12 ALA L 180
HIS L 181
LEU L 183
ALA L 184
PHE L 187
 None
BCL  L 602 (-4.0A)
BGL  L 701 (-3.3A)
BCL  L 602 (-3.5A)
None
 0.67A 5k9dA-1eysL:
0.0		 5k9dA-1eysL:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		4 / 8 HIS L 238
HIS L 198
LEU L 195
GLY L 199
 None
 0.74A 5m8rC-1eysL:
undetectable		 5m8rC-1eysL:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_B_ESTB602_1
(ESTROGEN RECEPTOR)		 1eys PHOTOSYNTHETIC
REACTION CENTER
(Thermochromatium
tepidum) 		5 / 10 LEU L 246
ALA L 245
ILE L 237
HIS L 198
LEU L 195
 None
BPH  L 606 ( 4.9A)
None
None
None
 1.21A 6cbzB-1eysL:
undetectable		 6cbzB-1eysL:
14.78