SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1eyx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZAW_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1eyx R-PHYCOERYTHRIN
(Gracilaria
chilensis) 		4 / 6 PHE A 131
LEU A  92
VAL A  93
VAL A  52
 None
 1.19A 2zawA-1eyxA:
undetectable		 2zawA-1eyxA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1eyx R-PHYCOERYTHRIN
(Gracilaria
chilensis) 		4 / 8 GLU A  25
SER A  26
ARG A  17
VAL A   8
 None
 1.36A 3jx1A-1eyxA:
1.2
3jx1B-1eyxA:
undetectable		 3jx1A-1eyxA:
17.69
3jx1B-1eyxA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLY_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1eyx R-PHYCOERYTHRIN
(Gracilaria
chilensis) 		4 / 8 GLU A  25
SER A  26
ARG A  17
VAL A   8
 None
 1.34A 3nlyA-1eyxA:
undetectable
3nlyB-1eyxA:
undetectable		 3nlyA-1eyxA:
17.95
3nlyB-1eyxA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQL_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1eyx R-PHYCOERYTHRIN
(Gracilaria
chilensis) 		4 / 8 GLU A  25
SER A  26
ARG A  17
VAL A   8
 None
 1.35A 3rqlA-1eyxA:
2.2
3rqlB-1eyxA:
undetectable		 3rqlA-1eyxA:
17.95
3rqlB-1eyxA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1eyx R-PHYCOERYTHRIN
(Gracilaria
chilensis) 		4 / 8 GLU A  25
SER A  26
ARG A  17
VAL A   8
 None
 1.33A 4capA-1eyxA:
undetectable
4capB-1eyxA:
undetectable		 4capA-1eyxA:
17.95
4capB-1eyxA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1eyx R-PHYCOERYTHRIN
(Gracilaria
chilensis) 		4 / 7 LEU A  44
GLY A 149
TYR A 152
SER A 153
 CYC  A 168 (-4.2A)
None
CYC  A 168 (-4.3A)
None
 0.63A 4cp3A-1eyxA:
0.0
4cp3B-1eyxA:
undetectable		 4cp3A-1eyxA:
21.82
4cp3B-1eyxA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D32_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1eyx R-PHYCOERYTHRIN
(Gracilaria
chilensis) 		4 / 8 GLU A  25
SER A  26
ARG A  17
VAL A   8
 None
 1.31A 4d32A-1eyxA:
undetectable
4d32B-1eyxA:
undetectable		 4d32A-1eyxA:
17.95
4d32B-1eyxA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1eyx R-PHYCOERYTHRIN
(Gracilaria
chilensis) 		5 / 11 ALA A 155
THR A 154
GLY A 100
GLY A 101
SER A  96
 None
 1.11A 4qvwK-1eyxA:
undetectable
4qvwL-1eyxA:
undetectable		 4qvwK-1eyxA:
21.92
4qvwL-1eyxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 1eyx R-PHYCOERYTHRIN
(Gracilaria
chilensis) 		4 / 4 THR A   6
GLY A 103
ASP A 106
SER A   3
 None
 1.25A 4rfqA-1eyxA:
undetectable		 4rfqA-1eyxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1eyx R-PHYCOERYTHRIN
(Gracilaria
chilensis) 		4 / 8 GLU A  25
SER A  26
ARG A  17
VAL A   8
 None
 1.32A 4v3yA-1eyxA:
undetectable
4v3yB-1eyxA:
undetectable		 4v3yA-1eyxA:
17.95
4v3yB-1eyxA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1eyx R-PHYCOERYTHRIN
(Gracilaria
chilensis) 		4 / 8 SER A  26
ARG A  17
VAL A   8
GLU A  25
 None
 1.35A 5uo7A-1eyxA:
undetectable
5uo7B-1eyxA:
1.6		 5uo7A-1eyxA:
18.46
5uo7B-1eyxA:
18.46