SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ez4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		3 / 3 TRP A 148
ALA A 274
VAL A 158
 None
 0.87A 1c4dA-1ez4A:
undetectable
1c4dB-1ez4A:
undetectable		 1c4dA-1ez4A:
8.13
1c4dB-1ez4A:
8.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CET_A_CLQA1001_0
(PROTEIN (L-LACTATE
DEHYDROGENASE))		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		6 / 9 VAL A  26
GLY A  27
ASP A  52
TYR A  83
ALA A  96
ILE A 116
 None
NAD  A1352 ( 4.0A)
NAD  A1352 (-3.0A)
None
NAD  A1352 (-3.5A)
NAD  A1352 (-3.8A)
 0.74A 1cetA-1ez4A:
40.4		 1cetA-1ez4A:
33.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		5 / 8 ILE A 262
LEU A 134
ILE A 258
VAL A 272
ILE A 293
 None
 1.48A 1linA-1ez4A:
undetectable		 1linA-1ez4A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		5 / 9 ILE A  94
PHE A 133
TYR A  83
ILE A 120
ALA A  96
 None
None
None
NAD  A1352 ( 4.9A)
NAD  A1352 (-3.5A)
 1.15A 1mrgA-1ez4A:
undetectable		 1mrgA-1ez4A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		4 / 4 LEU A  91
ILE A 159
ILE A 293
ALA A 261
 None
 0.73A 2i30A-1ez4A:
0.1		 2i30A-1ez4A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		3 / 3 ALA A 136
GLY A 252
SER A 259
 NAD  A1352 (-4.2A)
None
None
 0.56A 2ivuA-1ez4A:
0.0		 2ivuA-1ez4A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		6 / 12 LEU A 321
ASP A 141
GLY A 162
ILE A 189
ALA A 318
ILE A 287
 None
 1.40A 2nmzA-1ez4A:
undetectable		 2nmzA-1ez4A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		3 / 3 SER A 317
GLU A 230
ASP A 223
 None
 0.80A 2zulA-1ez4A:
7.0		 2zulA-1ez4A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_2
(PROTEASE)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		5 / 12 LEU A 117
ALA A  96
LEU A 134
VAL A 121
ILE A 120
 None
NAD  A1352 (-3.5A)
None
None
NAD  A1352 ( 4.9A)
 0.89A 3em6B-1ez4A:
undetectable		 3em6B-1ez4A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_A_PXLA313_1
(PYRIDOXAL KINASE)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		4 / 4 SER A 317
HIS A 193
THR A 163
VAL A 140
 None
NAD  A1352 (-3.6A)
None
NAD  A1352 (-4.2A)
 1.24A 3fhxA-1ez4A:
2.4		 3fhxA-1ez4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		5 / 12 TYR A  35
LEU A 134
SER A 259
SER A 167
ILE A 159
 None
 1.30A 3frqA-1ez4A:
0.0		 3frqA-1ez4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		5 / 12 GLY A 250
TYR A  35
LEU A 134
SER A 259
ILE A 159
 None
 1.05A 3frqB-1ez4A:
0.0		 3frqB-1ez4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_A_SAMA301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		3 / 3 TYR A 280
THR A 289
GLU A 310
 None
 0.82A 4df3A-1ez4A:
6.5		 4df3A-1ez4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_1
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		3 / 3 TYR A 280
THR A 289
GLU A 310
 None
 0.82A 4df3B-1ez4A:
0.2		 4df3B-1ez4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		4 / 6 GLY A 295
GLY A 294
ASN A 267
ILE A 132
 None
 0.93A 4fglD-1ez4A:
4.3		 4fglD-1ez4A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		4 / 4 ILE A 116
SER A 119
ASP A  52
ASP A  56
 NAD  A1352 (-3.8A)
NAD  A1352 (-3.0A)
NAD  A1352 (-3.0A)
None
 1.42A 4krhB-1ez4A:
4.8		 4krhB-1ez4A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		4 / 5 ASN A 113
LEU A 143
SER A 118
LEU A 329
 NAD  A1352 ( 4.7A)
None
None
None
 1.28A 4n09C-1ez4A:
6.3		 4n09C-1ez4A:
20.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4OKN_B_KANB403_1
(L-LACTATE
DEHYDROGENASE A
CHAIN)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		6 / 9 ASP A  52
VAL A  53
TYR A  83
ALA A  96
ILE A 116
ILE A 120
 NAD  A1352 (-3.0A)
NAD  A1352 (-4.3A)
None
NAD  A1352 (-3.5A)
NAD  A1352 (-3.8A)
NAD  A1352 ( 4.9A)
 0.46A 4oknB-1ez4A:
40.0		 4oknB-1ez4A:
36.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		3 / 3 VAL A 121
PHE A 129
ARG A 157
 None
 0.89A 4xr4B-1ez4A:
7.4		 4xr4B-1ez4A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		4 / 5 VAL A 214
VAL A 221
GLY A 219
PHE A 178
 None
 1.08A 5d4nA-1ez4A:
0.2
5d4nC-1ez4A:
0.0		 5d4nA-1ez4A:
16.23
5d4nC-1ez4A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		5 / 12 GLY A 191
GLY A 288
ILE A 285
ILE A 189
LEU A 311
 None
 0.95A 5fa8A-1ez4A:
6.6		 5fa8A-1ez4A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		5 / 12 PHE A 129
ALA A 136
SER A 161
VAL A  93
ILE A  94
 None
NAD  A1352 (-4.2A)
NAD  A1352 (-2.8A)
None
None
 1.44A 5mlmA-1ez4A:
7.6		 5mlmA-1ez4A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1804_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		5 / 8 GLY A 131
LEU A  25
VAL A  23
ILE A 262
GLY A 297
 None
 1.08A 5vkqB-1ez4A:
0.0
5vkqC-1ez4A:
0.0		 5vkqB-1ez4A:
10.91
5vkqC-1ez4A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		5 / 11 ALA A 227
LEU A 226
VAL A 211
ALA A 187
ALA A 173
 None
 1.18A 6h1lB-1ez4A:
0.0		 6h1lB-1ez4A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1ez4 LACTATE
DEHYDROGENASE
(Lactobacillus
pentosus) 		5 / 11 ASP A 186
TYR A 188
GLY A 191
SER A 317
ALA A 319
 None
 1.45A 6hu9A-1ez4A:
0.0
6hu9E-1ez4A:
undetectable
6hu9I-1ez4A:
undetectable		 6hu9A-1ez4A:
21.54
6hu9E-1ez4A:
23.17
6hu9I-1ez4A:
12.85