SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ezf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 6 SER A 356
THR A 359
ASN A 260
LEU A 259
 None
 1.13A 1mxdA-1ezfA:
undetectable		 1mxdA-1ezfA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 8 SER A 356
THR A 359
ASN A 260
LEU A 259
 None
 1.11A 1mxgA-1ezfA:
undetectable		 1mxgA-1ezfA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 7 THR A  42
TYR A  46
ASN A  48
LEU A  74
 None
 1.09A 1qzrA-1ezfA:
1.5		 1qzrA-1ezfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA502_1
(YKOF)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		5 / 6 PHE A 210
ALA A 266
LEU A 267
ILE A 263
CYH A 258
 None
 1.38A 1sbrA-1ezfA:
0.2
1sbrB-1ezfA:
0.5		 1sbrA-1ezfA:
22.38
1sbrB-1ezfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 8 MET A  65
LEU A  61
LEU A 280
GLY A 180
 None
None
None
IN0  A 991 (-3.2A)
 0.94A 2po5B-1ezfA:
undetectable		 2po5B-1ezfA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 7 LEU A  76
ALA A 176
GLY A 180
PHE A  72
 IN0  A 991 ( 4.6A)
IN0  A 991 (-4.1A)
IN0  A 991 (-3.2A)
IN0  A 991 ( 4.7A)
 0.92A 2wq5A-1ezfA:
0.0		 2wq5A-1ezfA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 8 SER A 355
ASN A 260
CYH A 258
ASN A 265
 None
 1.01A 3dmtC-1ezfA:
undetectable		 3dmtC-1ezfA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		5 / 12 LEU A 186
VAL A 142
ILE A 146
LEU A  47
TYR A  44
 None
 1.28A 3g9eA-1ezfA:
1.6		 3g9eA-1ezfA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		3 / 3 ASN A 205
ASP A 169
ARG A 218
 None
 0.91A 3k13C-1ezfA:
0.0		 3k13C-1ezfA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 8 PHE A 100
PHE A 103
ILE A 128
PHE A 111
 None
 0.97A 3ko0O-1ezfA:
undetectable
3ko0Q-1ezfA:
0.0		 3ko0O-1ezfA:
15.55
3ko0Q-1ezfA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_A_VORA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		5 / 9 ILE A 263
ALA A 266
THR A 214
ALA A 296
THR A 299
 None
 1.21A 3mdtA-1ezfA:
0.0		 3mdtA-1ezfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ARG A 218
PHE A 230
ARG A 228
ASP A  84
 None
 1.49A 5a06A-1ezfA:
undetectable		 5a06A-1ezfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ARG A 218
PHE A 230
ARG A 228
ASP A  84
 None
 1.48A 5a06C-1ezfA:
undetectable		 5a06C-1ezfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ARG A 218
PHE A 230
ARG A 228
ASP A  84
 None
 1.49A 5a06D-1ezfA:
undetectable		 5a06D-1ezfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ARG A 218
PHE A 230
ARG A 228
ASP A  84
 None
 1.48A 5a06E-1ezfA:
undetectable		 5a06E-1ezfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 7 ARG A 218
PHE A 230
ARG A 228
ASP A  84
 None
 1.50A 5a06F-1ezfA:
undetectable		 5a06F-1ezfA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		4 / 6 PHE A 210
VAL A 273
MET A 342
ILE A 338
 None
 1.20A 5iwuA-1ezfA:
undetectable		 5iwuA-1ezfA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		3 / 3 CYH A 172
LYS A 170
HIS A 173
 None
 1.26A 5js5A-1ezfA:
2.7		 5js5A-1ezfA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		5 / 10 ILE A 263
THR A 359
ILE A 362
ILE A 363
ILE A 366
 None
 1.05A 5murE-1ezfA:
0.0		 5murE-1ezfA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		5 / 10 TYR A 341
ILE A 297
ILE A 363
ILE A 366
ILE A 362
 None
 1.01A 5murE-1ezfA:
0.0		 5murE-1ezfA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1ezf FARNESYL-DIPHOSPHATE
FARNESYLTRANSFERASE
(Homo
sapiens) 		3 / 3 PHE A 210
ASP A 272
LEU A 178
 None
 0.76A 5uhcC-1ezfA:
0.9		 5uhcC-1ezfA:
14.91