SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ezr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 9 LEU A 112
LEU A 108
ILE A  33
THR A 122
ILE A   5
 None
 1.45A 1hzeA-1ezrA:
0.0
1hzeB-1ezrA:
0.0		 1hzeA-1ezrA:
17.89
1hzeB-1ezrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 9 LEU A 112
LEU A 108
THR A  34
THR A 122
ILE A   5
 None
 1.44A 1hzeA-1ezrA:
0.0
1hzeB-1ezrA:
0.0		 1hzeA-1ezrA:
17.89
1hzeB-1ezrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 9 THR A 122
ILE A   5
LEU A 112
LEU A 108
ILE A  33
 None
 1.45A 1hzeA-1ezrA:
0.0
1hzeB-1ezrA:
0.0		 1hzeA-1ezrA:
17.89
1hzeB-1ezrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZE_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 9 THR A 122
ILE A   5
LEU A 112
LEU A 108
THR A  34
 None
 1.45A 1hzeA-1ezrA:
0.0
1hzeB-1ezrA:
0.0		 1hzeA-1ezrA:
17.89
1hzeB-1ezrA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		3 / 3 VAL A 189
VAL A 292
ASP A 297
 None
 0.74A 2fumD-1ezrA:
0.0		 2fumD-1ezrA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 5 ALA A 105
ASN A 131
ILE A 132
ASP A   8
 None
 1.03A 2h4jA-1ezrA:
4.6		 2h4jA-1ezrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 12 PHE A 180
ILE A 263
THR A 271
LEU A 265
LEU A 151
 None
 1.21A 2jn3A-1ezrA:
undetectable		 2jn3A-1ezrA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 5 ALA A 105
ALA A  49
ALA A  53
VAL A  61
 None
 0.88A 2nyrB-1ezrA:
3.7		 2nyrB-1ezrA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBL_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 7 LEU A  42
VAL A  45
THR A  46
ASP A   8
 None
 0.72A 2qblA-1ezrA:
0.0		 2qblA-1ezrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 8 GLY A 190
GLY A 154
MET A 152
LEU A 129
VAL A 186
 None
 1.36A 3v1nA-1ezrA:
3.6		 3v1nA-1ezrA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		3 / 3 ARG A 258
GLU A 257
THR A 256
 None
 0.87A 3v4tA-1ezrA:
1.2		 3v4tA-1ezrA:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 5 PRO A  11
ASP A  10
ILE A  33
VAL A 124
 None
CA  A 401 (-3.0A)
None
None
 1.41A 4hytA-1ezrA:
2.2		 4hytA-1ezrA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 5 PRO A  11
ASP A  15
ILE A  33
VAL A 245
 None
CA  A 401 (-2.7A)
None
None
 1.32A 4hytA-1ezrA:
2.2		 4hytA-1ezrA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		3 / 3 ASP A 295
LEU A 294
PHE A 296
 None
 0.74A 4pthA-1ezrA:
0.2		 4pthA-1ezrA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 10 THR A 274
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.01A 4qvpK-1ezrA:
undetectable
4qvpL-1ezrA:
undetectable		 4qvpK-1ezrA:
22.43
4qvpL-1ezrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 10 THR A 274
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.00A 4qvpY-1ezrA:
undetectable
4qvpZ-1ezrA:
undetectable		 4qvpY-1ezrA:
22.43
4qvpZ-1ezrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 11 THR A 274
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.01A 4qw1K-1ezrA:
undetectable
4qw1L-1ezrA:
undetectable		 4qw1K-1ezrA:
22.12
4qw1L-1ezrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 10 THR A 274
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.01A 4qw1Y-1ezrA:
undetectable
4qw1Z-1ezrA:
undetectable		 4qw1Y-1ezrA:
22.12
4qw1Z-1ezrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 9 THR A 274
ALA A 176
ALA A 175
GLY A 154
GLY A 153
 None
 1.15A 4qwuY-1ezrA:
undetectable
4qwuZ-1ezrA:
undetectable		 4qwuY-1ezrA:
22.12
4qwuZ-1ezrA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 5 ALA A 197
LYS A 238
THR A 200
TYR A 236
 None
 1.29A 4w5oA-1ezrA:
2.0		 4w5oA-1ezrA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 6 ALA A 197
LYS A 238
THR A 200
TYR A 236
 None
 1.27A 4w5qA-1ezrA:
undetectable		 4w5qA-1ezrA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 6 ALA A 197
LYS A 238
THR A 200
TYR A 236
 None
 1.30A 4w5rA-1ezrA:
2.1		 4w5rA-1ezrA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 6 ALA A 197
LYS A 238
THR A 200
TYR A 236
 None
 1.33A 4w5tA-1ezrA:
0.0		 4w5tA-1ezrA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 6 ALA A 197
LYS A 238
THR A 200
TYR A 236
 None
 1.29A 4z4cA-1ezrA:
undetectable		 4z4cA-1ezrA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 5 ALA A 197
LYS A 238
THR A 200
TYR A 236
 None
 1.32A 4z4dA-1ezrA:
0.0		 4z4dA-1ezrA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA907_0
(PROTEIN ARGONAUTE-2)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 5 ALA A 197
LYS A 238
THR A 200
TYR A 236
 None
 1.31A 4z4eA-1ezrA:
undetectable		 4z4eA-1ezrA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		4 / 6 ALA A 197
LYS A 238
THR A 200
TYR A 236
 None
 1.27A 4z4fA-1ezrA:
undetectable		 4z4fA-1ezrA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 12 ILE A 132
ILE A   5
LEU A  30
VAL A  61
ILE A  33
 None
 1.09A 5mugA-1ezrA:
1.7		 5mugA-1ezrA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 10 PRO A  70
ALA A 176
GLY A 272
THR A 271
ILE A 263
 None
 1.02A 5vyhA-1ezrA:
0.0		 5vyhA-1ezrA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1ezr NUCLEOSIDE HYDROLASE
(Leishmania
major) 		5 / 12 LYS A 147
VAL A 146
ILE A 121
VAL A 124
ILE A   6
 None
 1.38A 6gsdA-1ezrA:
6.3		 6gsdA-1ezrA:
14.84