SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ezv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 ASP B  96
PHE B  93
VAL B 192
 None
 0.78A 1kijB-1ezvB:
0.5		 1kijB-1ezvB:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 284
LEU A 353
LEU A 425
 None
 0.64A 1mx1E-1ezvA:
undetectable		 1mx1E-1ezvA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
14 KD PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 LEU F  41
HIS F  79
ILE F  75
 None
 0.54A 1s9pB-1ezvF:
undetectable		 1s9pB-1ezvF:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 113
GLY A  51
ILE A 104
THR A  47
 None
 0.84A 1t7iB-1ezvA:
undetectable		 1t7iB-1ezvA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 113
GLY A  51
ILE A 104
THR A  47
 None
 0.84A 1t7jB-1ezvA:
undetectable		 1t7jB-1ezvA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_1
(CES1 PROTEIN)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  67
VAL A 143
LEU A 187
LEU A  71
LEU A 144
 None
 1.17A 1ya4B-1ezvA:
undetectable		 1ya4B-1ezvA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 7 LEU A  90
GLY A 211
ILE A 213
VAL A 105
 None
 0.79A 2aojB-1ezvA:
undetectable		 2aojB-1ezvA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG B  53
ASP B  83
ASP B 277
 None
 0.80A 2ejtA-1ezvB:
undetectable		 2ejtA-1ezvB:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		3 / 3 LEU A  92
LEU B 264
PHE A 118
 None
 0.58A 2pgrA-1ezvA:
undetectable		 2pgrA-1ezvA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
14 KD PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
UBIQUINONE-BINDING
PROTEIN QP-C
(Saccharomyces
cerevisiae) 		4 / 8 TYR F  73
GLN G  21
ARG A 251
ILE G  24
 None
 1.00A 2xytH-1ezvF:
undetectable		 2xytH-1ezvF:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  76
ASN A  81
PHE A 118
 None
 0.99A 2zbuD-1ezvA:
undetectable		 2zbuD-1ezvA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 432
LEU A 342
ASN A 313
LEU A 441
LEU A 347
 None
 1.20A 3a50E-1ezvA:
0.0		 3a50E-1ezvA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 PRO B 244
LEU B 284
ARG B  84
 None
 0.84A 3aqiB-1ezvB:
0.0		 3aqiB-1ezvB:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 1ezv CYTOCHROME C1
(Saccharomyces
cerevisiae) 		5 / 12 GLY D 221
GLY D  68
LEU D  69
PRO D 202
ALA D  65
 None
 1.08A 3av6A-1ezvD:
0.0		 3av6A-1ezvD:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 7 ASP B 358
SER B 294
GLU B 367
ASP B 366
 None
 1.03A 3bc9A-1ezvB:
undetectable		 3bc9A-1ezvB:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 389
THR A 210
VAL A  53
VAL A  50
GLY A  51
 None
 1.21A 3bf1A-1ezvA:
undetectable
3bf1B-1ezvA:
undetectable		 3bf1A-1ezvA:
19.53
3bf1B-1ezvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		5 / 12 VAL A  53
GLY A  51
SER A 106
PRO A 382
THR A 210
 None
 1.26A 3bjwF-1ezvA:
undetectable		 3bjwF-1ezvA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		5 / 11 VAL A  53
GLY A  51
SER A 106
PRO A 382
THR A 210
 None
 1.23A 3bjwH-1ezvA:
0.0		 3bjwH-1ezvA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 4 LEU B 264
ASP B 345
VAL B 255
THR B 321
 None
 1.21A 3cyxB-1ezvB:
0.0		 3cyxB-1ezvB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAT_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1ezv CYTOCHROME C1
(Saccharomyces
cerevisiae) 		5 / 12 ALA D 259
LEU D 255
LEU D 107
VAL D 110
ARG D  98
 None
 1.15A 3datA-1ezvD:
undetectable		 3datA-1ezvD:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 1ezv CYTOCHROME C1
(Saccharomyces
cerevisiae) 		5 / 12 VAL D  96
TYR D  97
LEU D 255
TYR D 198
ILE D 191
 None
None
None
None
HEM  D   3 (-4.4A)
 1.21A 3frqA-1ezvD:
undetectable		 3frqA-1ezvD:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_A_ROFA901_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 191
LEU A 192
GLN A 101
 None
 0.74A 3g4lA-1ezvA:
undetectable		 3g4lA-1ezvA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 402
GLN A 375
LEU A 373
GLU A 378
 None
 1.10A 3h5gB-1ezvA:
undetectable
3h5gC-1ezvA:
undetectable		 3h5gB-1ezvA:
5.91
3h5gC-1ezvA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B304_1
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 5 ASN A 387
THR A  47
SER A  49
SER A 115
 None
 1.25A 3hlwB-1ezvA:
0.0		 3hlwB-1ezvA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 6 VAL B 187
SER B 204
LEU B  67
LEU B  31
 None
 0.84A 3kk6A-1ezvB:
0.0		 3kk6A-1ezvB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 10 THR B  77
GLY B  75
GLU B  72
LEU B  94
ILE B  28
 None
 0.98A 3kvrA-1ezvB:
undetectable		 3kvrA-1ezvB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 10 THR B  77
GLY B  75
GLU B  72
LEU B  94
ILE B  28
 None
 0.94A 3kvrB-1ezvB:
undetectable		 3kvrB-1ezvB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
14 KD PROTEIN
(Saccharomyces
cerevisiae) 		4 / 5 LEU F  88
GLN F  80
THR F  81
GLU F  92
 None
 1.29A 3n58C-1ezvF:
undetectable		 3n58C-1ezvF:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 9 THR B  77
GLY B  75
GLU B  72
LEU B  94
ILE B  28
 None
 0.98A 3nbqA-1ezvB:
undetectable		 3nbqA-1ezvB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
UBIQUINONE-BINDING
PROTEIN QP-C
(Saccharomyces
cerevisiae) 		3 / 3 ALA G  28
VAL G  29
GLN G  34
 None
 0.70A 3of4B-1ezvG:
undetectable		 3of4B-1ezvG:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 1ezv CYTOCHROME C1
(Saccharomyces
cerevisiae) 		4 / 8 ALA D 248
VAL D 251
LEU D 255
LEU D 194
 None
 0.78A 3roxA-1ezvD:
undetectable		 3roxA-1ezvD:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		3 / 3 THR A 210
VAL A 208
GLU A  41
 None
 0.77A 3v4tA-1ezvA:
0.0
3v4tD-1ezvA:
0.0		 3v4tA-1ezvA:
22.95
3v4tD-1ezvA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX7_B_DM2B1104_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 8 SER B 249
GLN B 252
ILE B 241
VAL B 305
 None
 0.95A 4dx7B-1ezvB:
3.4		 4dx7B-1ezvB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1ezv CYTOCHROME C1
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
UBIQUINONE-BINDING
PROTEIN QP-C
(Saccharomyces
cerevisiae) 		4 / 7 MET A 445
ALA D 293
THR D 297
VAL G  29
 None
 0.99A 4ik7A-1ezvA:
0.0		 4ik7A-1ezvA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		5 / 12 SER A 320
LEU A 319
TYR A 274
GLN A 372
GLY A 285
 None
 1.41A 4j7xF-1ezvA:
undetectable		 4j7xF-1ezvA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 250
ARG A 249
MET A 445
 None
 0.90A 4m11C-1ezvA:
0.0		 4m11C-1ezvA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		5 / 9 VAL A 417
ILE A 430
VAL A 264
ALA A 263
ALA A 280
 None
 1.22A 4oqrA-1ezvA:
0.0		 4oqrA-1ezvA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 7 ASN B 352
GLU B 227
GLU B 228
TYR B 353
 None
 1.32A 4r87I-1ezvB:
0.0		 4r87I-1ezvB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 SER B 237
ALA B 355
VAL B 354
 None
 0.64A 4x20C-1ezvB:
undetectable		 4x20C-1ezvB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 342
ILE A 343
LEU A 347
ILE A 447
ILE A 432
 None
 0.91A 4y0rA-1ezvA:
1.4		 4y0rA-1ezvA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 4 VAL B  68
ALA B  64
ASN B  58
GLN B  57
 None
 1.22A 4zgfA-1ezvB:
0.0		 4zgfA-1ezvB:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 290
ARG A 334
ASP A 312
TYR A 287
 None
 1.33A 5a06A-1ezvA:
undetectable		 5a06A-1ezvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 290
ARG A 334
ASP A 312
TYR A 287
 None
 1.35A 5a06B-1ezvA:
0.0		 5a06B-1ezvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 290
ARG A 334
ASP A 312
TYR A 287
 None
 1.37A 5a06C-1ezvA:
undetectable		 5a06C-1ezvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 290
ARG A 334
ASP A 312
TYR A 287
 None
 1.33A 5a06D-1ezvA:
undetectable		 5a06D-1ezvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 290
ARG A 334
ASP A 312
TYR A 287
 None
 1.35A 5a06E-1ezvA:
undetectable		 5a06E-1ezvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 290
ARG A 334
ASP A 312
TYR A 287
 None
 1.33A 5a06F-1ezvA:
undetectable		 5a06F-1ezvA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ezv CYTOCHROME C1
(Saccharomyces
cerevisiae) 		3 / 3 THR D 114
HIS D 105
LEU D 255
 None
HEM  D   3 (-3.2A)
None
 0.77A 5axdA-1ezvD:
undetectable		 5axdA-1ezvD:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ezv CYTOCHROME C1
(Saccharomyces
cerevisiae) 		3 / 3 THR D 114
HIS D 105
LEU D 255
 None
HEM  D   3 (-3.2A)
None
 0.81A 5axdC-1ezvD:
0.0		 5axdC-1ezvD:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 8 SER A  56
HIS A 199
PRO A 235
LEU A 237
 None
 1.14A 5dzkF-1ezvA:
0.0
5dzkT-1ezvA:
undetectable		 5dzkF-1ezvA:
18.79
5dzkT-1ezvA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU B  98
GLY B 189
VAL B 193
GLU A 378
GLY A 380
 None
 1.28A 5f9zA-1ezvB:
undetectable		 5f9zA-1ezvB:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG B  40
THR B 280
ASP B 281
 None
 0.96A 5g5gA-1ezvB:
undetectable
5g5gB-1ezvB:
0.0		 5g5gA-1ezvB:
22.13
5g5gB-1ezvB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 PHE B  78
GLY A 285
SER A 286
GLY B  75
LEU A 279
 None
 1.06A 5gwxA-1ezvB:
undetectable		 5gwxA-1ezvB:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IFU_A_GBMA801_1
(PROLINE--TRNA LIGASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		5 / 12 PHE A 243
LEU A 342
THR A 331
ILE A 260
ILE A 432
 None
 1.07A 5ifuA-1ezvA:
undetectable		 5ifuA-1ezvA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 362
ALA A 280
VAL A 417
GLY A 328
PHE A 314
 None
 1.25A 5igiA-1ezvA:
0.0		 5igiA-1ezvA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NY7_A_NCAA303_0
(AMIDASE)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 424
GLY A 325
GLU A 267
SER A 271
 None
 1.03A 5ny7A-1ezvA:
undetectable		 5ny7A-1ezvA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
(Saccharomyces
cerevisiae) 		4 / 7 SER A 320
ALA A 277
ILE A 409
LEU A 369
 None
 1.05A 5te8A-1ezvA:
0.0		 5te8A-1ezvA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 4 LEU B 270
GLY B 269
SER B 268
SER B 265
 None
 1.39A 5uunA-1ezvB:
0.0		 5uunA-1ezvB:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
CYTOCHROME C1
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
UBIQUINONE-BINDING
PROTEIN QP-C
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 LEU A 250
THR G  25
VAL D 301
ASN D 303
GLU A 182
 None
 1.15A 5v1tA-1ezvA:
undetectable		 5v1tA-1ezvA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6GIQ_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
7.3 KD PROTEIN
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 9 ASP A 427
SER A 452
MET A 454
VAL I  18
ILE I  21
 None
 1.10A 6giqA-1ezvA:
0.0
6giqE-1ezvA:
0.0
6giqI-1ezvA:
0.0		 6giqA-1ezvA:
99.54
6giqE-1ezvA:
20.77
6giqI-1ezvA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 8 GLY B  46
HIS B  49
VAL B 123
GLY B  37
ALA B 176
 None
 1.18A 6hu9H-1ezvB:
undetectable
6hu9e-1ezvB:
0.0		 6hu9H-1ezvB:
12.94
6hu9e-1ezvB:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
7.3 KD PROTEIN
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 TRP A 426
ASP A 427
SER A 452
MET A 454
VAL I  18
 None
 0.84A 6hu9A-1ezvA:
0.0
6hu9E-1ezvA:
0.0
6hu9I-1ezvA:
0.0		 6hu9A-1ezvA:
99.54
6hu9E-1ezvA:
17.87
6hu9I-1ezvA:
10.82