SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ezw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 ALA A 130
VAL A 154
TRP A 117
 None
 0.97A 1av2A-1ezwA:
undetectable
1av2B-1ezwA:
undetectable		 1av2A-1ezwA:
4.63
1av2B-1ezwA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 TRP A 117
ALA A 130
VAL A 154
 None
 0.87A 1bdwA-1ezwA:
undetectable
1bdwB-1ezwA:
undetectable		 1bdwA-1ezwA:
4.63
1bdwB-1ezwA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 ASP A 303
ASP A 239
ASP A 309
 None
 0.69A 1eizA-1ezwA:
undetectable		 1eizA-1ezwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 ASP A 303
ASP A 239
ASP A 309
 None
 0.65A 1ej0A-1ezwA:
undetectable		 1ej0A-1ezwA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		4 / 8 TYR A 174
TYR A 229
GLN A 321
TYR A 139
 None
 1.01A 1nx9A-1ezwA:
undetectable		 1nx9A-1ezwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		4 / 8 TYR A 174
TYR A 229
GLN A 321
TYR A 139
 None
 1.02A 1nx9B-1ezwA:
undetectable		 1nx9B-1ezwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		4 / 8 TYR A 174
TYR A 229
GLN A 321
TYR A 139
 None
 1.02A 1nx9C-1ezwA:
undetectable		 1nx9C-1ezwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		4 / 8 TYR A 174
TYR A 229
GLN A 321
TYR A 139
 None
 1.02A 1nx9D-1ezwA:
undetectable		 1nx9D-1ezwA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 ALA A 130
VAL A 154
TRP A 117
 None
 0.94A 1w5uA-1ezwA:
undetectable
1w5uB-1ezwA:
undetectable		 1w5uA-1ezwA:
4.63
1w5uB-1ezwA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 VAL A 260
VAL A 253
ASP A  99
 None
 0.77A 2fumD-1ezwA:
undetectable		 2fumD-1ezwA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 TRP A 117
ALA A 130
VAL A 154
 None
 0.87A 2izqC-1ezwA:
undetectable
2izqD-1ezwA:
undetectable		 2izqC-1ezwA:
4.63
2izqD-1ezwA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_NCAA493_0
(CHORISMATE SYNTHASE)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		5 / 11 ALA A  26
ILE A 328
ILE A  23
ALA A  34
VAL A 324
 None
 1.12A 2qhfA-1ezwA:
0.0		 2qhfA-1ezwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		4 / 6 LEU A  10
ILE A 328
ILE A 295
MET A 294
 None
 0.97A 2xkwB-1ezwA:
0.0		 2xkwB-1ezwA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		4 / 8 LYS A 105
ARG A  71
TYR A  45
ASP A  99
 None
CL  A 362 (-4.8A)
None
None
 1.35A 3dh0A-1ezwA:
undetectable		 3dh0A-1ezwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 ASP A 303
ASP A 239
ASP A 309
 None
 0.78A 3douA-1ezwA:
undetectable		 3douA-1ezwA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		5 / 12 THR A 306
ILE A 300
SER A 198
VAL A 290
ILE A 247
 None
 1.06A 3frqB-1ezwA:
0.0		 3frqB-1ezwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		5 / 12 GLY A 318
ALA A 228
ALA A   2
ALA A 206
VAL A 207
 None
 1.06A 3jb3A-1ezwA:
0.0		 3jb3A-1ezwA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 TRP A 117
ALA A 130
VAL A 154
 None
 0.92A 3l8lC-1ezwA:
undetectable
3l8lD-1ezwA:
undetectable		 3l8lC-1ezwA:
4.63
3l8lD-1ezwA:
5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		5 / 10 TYR A  45
LEU A  83
ASP A  84
ALA A  81
ALA A  91
 None
 1.12A 3rodC-1ezwA:
0.6		 3rodC-1ezwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		4 / 8 ALA A 244
PHE A 232
ALA A 301
THR A 306
 None
 0.96A 3t3sF-1ezwA:
0.0		 3t3sF-1ezwA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		5 / 11 ILE A 336
ALA A  26
GLU A  32
VAL A 324
VAL A 322
 None
 1.07A 3tmzA-1ezwA:
0.0		 3tmzA-1ezwA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1477_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		4 / 6 THR A 185
GLY A 187
ILE A 224
LEU A 183
 None
 1.26A 4acaC-1ezwA:
undetectable		 4acaC-1ezwA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		4 / 5 PHE A 251
PHE A 283
ILE A 278
GLY A 279
 None
 0.98A 4ejjC-1ezwA:
0.0		 4ejjC-1ezwA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA8_C_Z80C301_1
(MAJOR PRION PROTEIN)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		4 / 5 GLY A 284
ILE A 274
LYS A 270
GLN A 273
 None
 1.18A 4ma8C-1ezwA:
0.0		 4ma8C-1ezwA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		5 / 11 ASP A 225
VAL A 195
ALA A 177
GLY A 318
PHE A 203
 None
 1.22A 4mm9A-1ezwA:
undetectable		 4mm9A-1ezwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_A_SAMA301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		5 / 12 GLN A 178
GLY A 255
ASP A 258
GLU A 272
ALA A 275
 None
 1.11A 4pclA-1ezwA:
2.1		 4pclA-1ezwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		5 / 12 GLY A 329
ALA A 241
PHE A 232
ILE A 328
ILE A 336
 None
 1.10A 4uw0A-1ezwA:
undetectable		 4uw0A-1ezwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		5 / 10 ALA A 186
GLY A  94
LEU A 194
ALA A 227
ASP A 225
 None
 1.49A 5ajqB-1ezwA:
undetectable		 5ajqB-1ezwA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		3 / 3 ILE A 131
ILE A  93
MET A 182
 None
 0.65A 5i9yA-1ezwA:
undetectable		 5i9yA-1ezwA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 1ezw COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanopyrus
kandleri) 		4 / 4 VAL A 307
GLY A 302
ASP A 303
ASP A 235
 None
 1.16A 6cjkC-1ezwA:
undetectable		 6cjkC-1ezwA:
22.77