SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f07'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 8 ILE A 185
MET A 157
VAL A  62
GLY A 162
 None
None
MPO  A 331 (-3.9A)
None
 0.97A 1dzmA-1f07A:
0.0		 1dzmA-1f07A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 ILE A 185
MET A 157
VAL A  62
GLY A 162
 None
None
MPO  A 331 (-3.9A)
None
 1.05A 1e06B-1f07A:
0.0		 1e06B-1f07A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 246
ILE A 227
PHE A 273
ALA A 172
GLN A 153
 None
MPO  A 331 (-4.8A)
None
MPD  A 335 ( 4.9A)
None
 1.34A 1oltA-1f07A:
0.2		 1oltA-1f07A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ALA A 202
TYR A 297
ALA A 299
GLY A 300
GLY A   4
 None
None
None
MPO  A 331 ( 4.1A)
None
 1.19A 2v7bA-1f07A:
undetectable		 2v7bA-1f07A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 9 ALA A 202
TYR A 297
ALA A 299
GLY A 300
GLY A   4
 None
None
None
MPO  A 331 ( 4.1A)
None
 1.20A 2v7bB-1f07A:
undetectable		 2v7bB-1f07A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  58
GLY A  59
GLY A  91
ASP A  35
LEU A  80
 None
 1.10A 2zbpA-1f07A:
undetectable		 2zbpA-1f07A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  58
GLY A  59
GLY A  91
ASP A  35
LEU A  80
 None
 1.18A 3cjtG-1f07A:
undetectable		 3cjtG-1f07A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 4 GLY A  91
TYR A 149
GLY A 167
ASP A 166
 None
 1.09A 3kl3A-1f07A:
11.0		 3kl3A-1f07A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LD6_A_KKKA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 PHE A 236
PHE A 273
GLY A 246
ALA A 229
ILE A 170
 None
None
None
None
MPD  A 335 (-4.8A)
 1.32A 3ld6A-1f07A:
0.0		 3ld6A-1f07A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  80
THR A  53
VAL A  20
ILE A  16
VAL A  17
 None
 0.97A 4c9lA-1f07A:
undetectable		 4c9lA-1f07A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  80
THR A  53
VAL A  20
ILE A  16
VAL A  17
 None
 0.95A 4c9lB-1f07A:
undetectable		 4c9lB-1f07A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  80
THR A  53
VAL A  20
ILE A  16
VAL A  17
 None
 0.98A 4c9oA-1f07A:
undetectable		 4c9oA-1f07A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 LEU A  80
THR A  53
VAL A  20
ILE A  16
VAL A  17
 None
 0.99A 4c9oB-1f07A:
undetectable		 4c9oB-1f07A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 LEU A  80
THR A  53
VAL A  20
ILE A  16
VAL A  17
 None
 1.04A 4jx1B-1f07A:
undetectable		 4jx1B-1f07A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		3 / 3 ALA A 161
GLN A 296
GLY A   4
 None
 0.63A 4odoC-1f07A:
0.0		 4odoC-1f07A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QE6_A_JN3A1001_1
(BILE ACID RECEPTOR)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 MET A 157
ALA A 152
SER A 165
ILE A 164
ILE A  92
 None
 1.14A 4qe6A-1f07A:
0.0		 4qe6A-1f07A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EQB_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 12 GLY A 127
GLY A  95
GLY A  93
LEU A  90
THR A 123
 None
 1.00A 5eqbA-1f07A:
0.0		 5eqbA-1f07A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		5 / 10 SER A 165
ALA A 202
LEU A 169
GLY A 151
ILE A  16
 None
 1.17A 5oy01-1f07A:
0.0
5oy07-1f07A:
undetectable		 5oy01-1f07A:
14.02
5oy07-1f07A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 ILE A 311
PHE A 282
LEU A 314
ILE A  33
 None
 0.84A 6b5vA-1f07A:
0.0
6b5vC-1f07A:
0.0		 6b5vA-1f07A:
13.75
6b5vC-1f07A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 ILE A 311
PHE A 282
LEU A 314
ILE A  33
 None
 0.84A 6b5vA-1f07A:
0.0
6b5vB-1f07A:
0.0		 6b5vA-1f07A:
13.75
6b5vB-1f07A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 ILE A 311
PHE A 282
LEU A 314
ILE A  33
 None
 0.83A 6b5vC-1f07A:
0.0
6b5vD-1f07A:
0.0		 6b5vC-1f07A:
13.75
6b5vD-1f07A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE
(Methanothermobac
ter
thermautotrophic
us) 		4 / 7 ILE A 311
PHE A 282
LEU A 314
ILE A  33
 None
 0.84A 6b5vB-1f07A:
0.0
6b5vD-1f07A:
0.0		 6b5vB-1f07A:
13.75
6b5vD-1f07A:
13.75