SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 LEU A 326
LEU A 329
VAL A 330
SER A 332
LEU A 344
 None
 1.32A 1db1A-1f0iA:
0.0		 1db1A-1f0iA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_A_PFLA4002_1
(SERUM ALBUMIN)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		3 / 3 PHE A 286
LEU A  18
SER A 324
 None
 0.87A 1e7aA-1f0iA:
undetectable		 1e7aA-1f0iA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 10 ILE A 393
ALA A 346
ILE A 339
ILE A 399
THR A 347
 None
 1.29A 1j3jA-1f0iA:
undetectable		 1j3jA-1f0iA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RTS_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 7 ARG A 373
ILE A 374
ASP A 355
LEU A 358
 None
 0.89A 1rtsB-1f0iA:
undetectable		 1rtsB-1f0iA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 5 LYS A 464
PHE A 459
LEU A 326
LEU A 182
 None
 1.38A 1skxA-1f0iA:
0.0		 1skxA-1f0iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 11 VAL A 454
VAL A 452
TYR A 460
LEU A  11
ILE A 477
 None
 0.92A 1t6zB-1f0iA:
undetectable		 1t6zB-1f0iA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB6_0
(GRAMICIDIN A)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		3 / 3 ALA A 215
VAL A  29
TRP A  30
 None
 0.93A 1tkqB-1f0iA:
undetectable		 1tkqB-1f0iA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_B_CQAB401_0
(HISTAMINE
N-METHYLTRANSFERASE)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 7 TRP A 470
GLY A 274
PRO A 321
ASP A 317
 None
 1.16A 2aouB-1f0iA:
2.3		 2aouB-1f0iA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 7 SER A 480
SER A  34
ARG A  32
LEU A  11
 None
 1.03A 2cdqB-1f0iA:
0.0		 2cdqB-1f0iA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 9 LEU A 428
LEU A 426
LEU A 344
ILE A 399
TYR A 359
 None
 1.27A 2f78B-1f0iA:
undetectable		 2f78B-1f0iA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 7 GLY A 272
THR A 161
ILE A 277
GLY A 274
 None
 0.80A 2jkjE-1f0iA:
0.0		 2jkjE-1f0iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 7 GLY A 272
THR A 161
ILE A 277
GLY A 274
 None
 0.84A 2jklA-1f0iA:
undetectable		 2jklA-1f0iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 7 GLY A 272
THR A 161
ILE A 277
GLY A 274
 None
 0.84A 2jklC-1f0iA:
0.0		 2jklC-1f0iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 7 GLY A 272
THR A 161
ILE A 277
GLY A 274
 None
 0.83A 2jklE-1f0iA:
0.0		 2jklE-1f0iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 7 GLY A 272
THR A 161
ILE A 277
GLY A 274
 None
 0.83A 2jklF-1f0iA:
0.0		 2jklF-1f0iA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		3 / 3 LEU A 207
TYR A 476
GLY A 462
 None
 0.54A 2ocuA-1f0iA:
undetectable		 2ocuA-1f0iA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		3 / 3 TYR A 218
GLU A 322
ASN A 465
 None
None
PO4  A 600 (-3.1A)
 0.74A 2y7hC-1f0iA:
0.9		 2y7hC-1f0iA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 THR A 221
GLY A 274
GLY A 272
ASP A 473
ASP A 279
 None
 1.22A 2zw9B-1f0iA:
undetectable		 2zw9B-1f0iA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 GLU A 322
GLU A 323
SER A 167
VAL A 275
TYR A 316
 None
 1.35A 3bjmA-1f0iA:
undetectable		 3bjmA-1f0iA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 GLU A 322
GLU A 323
SER A 167
VAL A 275
TYR A 316
 None
 1.34A 3bjmB-1f0iA:
2.1		 3bjmB-1f0iA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB262_1
(GLUTAMATE RECEPTOR 2)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 10 ILE A  78
SER A 109
GLY A  79
LEU A 174
SER A 180
 None
 1.28A 3ik6B-1f0iA:
0.0
3ik6E-1f0iA:
0.0		 3ik6B-1f0iA:
20.47
3ik6E-1f0iA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		3 / 3 LEU A 222
TRP A 225
GLY A 276
 None
 0.81A 3l35B-1f0iA:
undetectable
3l35K-1f0iA:
undetectable		 3l35B-1f0iA:
6.63
3l35K-1f0iA:
3.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 ALA A 206
LEU A  49
LEU A 487
LEU A 451
LEU A 326
 None
 1.19A 3r9cA-1f0iA:
0.0		 3r9cA-1f0iA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		3 / 3 PHE A 431
SER A 499
GLN A 495
 None
 0.96A 3smtA-1f0iA:
0.0		 3smtA-1f0iA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 GLU A 322
GLU A 323
SER A 167
VAL A 275
TYR A 316
 None
 1.36A 3w2tA-1f0iA:
undetectable		 3w2tA-1f0iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 GLU A 322
GLU A 323
SER A 167
VAL A 275
TYR A 316
 None
 1.37A 3w2tB-1f0iA:
undetectable		 3w2tB-1f0iA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 9 ILE A 268
GLY A 475
THR A 183
LEU A 205
LEU A  38
 None
 1.16A 4ze0A-1f0iA:
undetectable		 4ze0A-1f0iA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 LEU A 207
GLY A  40
ASN A  80
THR A  75
VAL A 175
 None
 1.27A 5d0yA-1f0iA:
0.2		 5d0yA-1f0iA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 4 LEU A 428
TYR A 445
PRO A 379
ILE A 393
 None
 1.34A 5esgA-1f0iA:
0.0		 5esgA-1f0iA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 5 ALA A 312
PRO A 468
GLY A 185
LEU A 326
 None
 0.93A 5eslA-1f0iA:
undetectable		 5eslA-1f0iA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 THR A 160
SER A 167
ALA A 124
GLY A 123
ASP A 473
 None
 1.28A 5l66H-1f0iA:
undetectable
5l66I-1f0iA:
undetectable		 5l66H-1f0iA:
17.93
5l66I-1f0iA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 6 ASP A 378
ASP A 506
ARG A 373
GLN A 495
 None
 1.28A 5l6eA-1f0iA:
0.4		 5l6eA-1f0iA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 TYR A 476
THR A 208
ALA A 212
LYS A  73
GLY A  40
 None
 1.17A 5lf7V-1f0iA:
undetectable
5lf7b-1f0iA:
undetectable		 5lf7V-1f0iA:
19.80
5lf7b-1f0iA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 TYR A 476
THR A 208
ALA A 212
LYS A  73
GLY A  40
 None
 1.18A 5lf7H-1f0iA:
undetectable
5lf7N-1f0iA:
undetectable		 5lf7H-1f0iA:
19.80
5lf7N-1f0iA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		3 / 3 HIS A 198
ASP A 441
HIS A 443
 None
 0.85A 5n1tW-1f0iA:
undetectable		 5n1tW-1f0iA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 8 GLY A 213
ARG A 119
VAL A 175
ASP A  86
 None
 0.92A 5vlmA-1f0iA:
undetectable		 5vlmA-1f0iA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 VAL A 330
LEU A 487
LEU A 451
LEU A 492
GLY A 335
 None
 0.93A 6b0cD-1f0iA:
undetectable		 6b0cD-1f0iA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		5 / 12 GLU A 322
GLU A 323
SER A 167
VAL A 275
TYR A 316
 None
 1.38A 6b1eB-1f0iA:
undetectable		 6b1eB-1f0iA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 6 GLN A 447
VAL A 375
GLU A 338
ALA A 484
 None
 1.14A 6djzB-1f0iA:
0.0		 6djzB-1f0iA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1f0i PHOSPHOLIPASE D
(Streptomyces
sp.
PMF) 		4 / 5 ILE A 186
GLN A  51
THR A  52
THR A 183
 None
 0.86A 6f3mD-1f0iA:
undetectable		 6f3mD-1f0iA:
22.18