SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		3 / 3 ASN A 255
TRP A 208
GLN A 241
 None
 1.00A 1xoqA-1f0pA:
undetectable		 1xoqA-1f0pA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 121
GLN A 270
LEU A 149
LEU A 278
ARG A 206
 None
None
None
None
MES  A1101 (-3.5A)
 1.36A 2ceoB-1f0pA:
0.0		 2ceoB-1f0pA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		4 / 8 ALA A 187
ASN A 191
PRO A 155
PRO A 161
 None
 0.81A 3fxrA-1f0pA:
0.1		 3fxrA-1f0pA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  57
GLY A 268
LEU A  38
ASN A  54
ILE A 123
 None
 1.12A 3wdmD-1f0pA:
1.9		 3wdmD-1f0pA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  38
ASN A  49
LEU A 105
ILE A  22
 None
 0.99A 4okwA-1f0pA:
undetectable		 4okwA-1f0pA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  88
GLY A 173
SER A  76
ALA A  90
ARG A  20
 None
 1.07A 4qtuB-1f0pA:
undetectable		 4qtuB-1f0pA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  88
GLY A 173
SER A  76
ALA A  90
ARG A  20
 None
 1.05A 4qtuD-1f0pA:
undetectable		 4qtuD-1f0pA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 271
ILE A 123
ALA A 121
ALA A 284
GLY A  29
 None
 0.95A 5veuB-1f0pA:
undetectable		 5veuB-1f0pA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 214
GLY A 260
ASN A 231
SER A 150
PHE A 228
 None
None
TRE  A1152 ( 4.5A)
None
None
 1.47A 5yf0A-1f0pA:
2.0		 5yf0A-1f0pA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  88
GLN A  93
TYR A  95
TYR A 174
 None
 0.98A 6ag0A-1f0pA:
0.5		 6ag0A-1f0pA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)		 1f0p ANTIGEN 85-B
(Mycobacterium
tuberculosis) 		4 / 6 GLY A  88
GLN A  93
TYR A  95
TYR A 174
 None
 0.96A 6ag0C-1f0pA:
undetectable		 6ag0C-1f0pA:
14.07