SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_B_FUAB703_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	1f1e	HISTONE FOLD PROTEIN (Methanopyrus kandleri)	3 / 3	VAL A 105 ALA A 104 HIS A 62	None CL A1001 ( 4.9A) None	0.68A	1q23C-1f1eA: undetectable	1q23C-1f1eA: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_C_FUAC701_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	1f1e	HISTONE FOLD PROTEIN (Methanopyrus kandleri)	4 / 4	ALA A 100 VAL A 105 ALA A 104 HIS A 62	None None CL A1001 ( 4.9A) None	1.12A	1q23A-1f1eA: undetectable	1q23A-1f1eA: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_E_FUAE706_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	1f1e	HISTONE FOLD PROTEIN (Methanopyrus kandleri)	4 / 4	ALA A 100 VAL A 105 ALA A 104 HIS A 62	None None CL A1001 ( 4.9A) None	1.21A	1q23F-1f1eA: undetectable	1q23F-1f1eA: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_G_FUAG708_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	1f1e	HISTONE FOLD PROTEIN (Methanopyrus kandleri)	3 / 3	VAL A 105 ALA A 104 HIS A 62	None CL A1001 ( 4.9A) None	0.56A	1q23H-1f1eA: undetectable	1q23H-1f1eA: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_I_FUAI707_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	1f1e	HISTONE FOLD PROTEIN (Methanopyrus kandleri)	3 / 3	VAL A 105 ALA A 104 HIS A 62	None CL A1001 ( 4.9A) None	0.66A	1q23G-1f1eA: undetectable	1q23G-1f1eA: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_J_FUAJ711_2 (CHLORAMPHENICOL ACETYLTRANSFERASE)	1f1e	HISTONE FOLD PROTEIN (Methanopyrus kandleri)	4 / 4	ALA A 100 VAL A 105 ALA A 104 HIS A 62	None None CL A1001 ( 4.9A) None	1.07A	1q23K-1f1eA: undetectable	1q23K-1f1eA: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q23_L_FUAL710_1 (CHLORAMPHENICOL ACETYLTRANSFERASE)	1f1e	HISTONE FOLD PROTEIN (Methanopyrus kandleri)	3 / 3	VAL A 105 ALA A 104 HIS A 62	None CL A1001 ( 4.9A) None	0.55A	1q23J-1f1eA: undetectable	1q23J-1f1eA: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEK_A_DIFA1376_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	1f1e	HISTONE FOLD PROTEIN (Methanopyrus kandleri)	4 / 8	TYR A 108 LEU A 107 LEU A 63 ALA A 67	None	0.96A	2wekA-1f1eA: undetectable	2wekA-1f1eA: 21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4M2V_A_BZ1A302_2 (CARBONIC ANHYDRASE 2)	1f1e	HISTONE FOLD PROTEIN (Methanopyrus kandleri)	3 / 3	HIS A 62 VAL A 75 LEU A 107	None	0.68A	4m2vA-1f1eA: undetectable	4m2vA-1f1eA: 21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IH0_A_ACTA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E II)	1f1e	HISTONE FOLD PROTEIN (Methanopyrus kandleri)	4 / 6	PHE A 34 PRO A 36 THR A 116 ILE A 31	None	1.31A	5ih0A-1f1eA: undetectable	5ih0A-1f1eA: 22.07

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1Q23_B_FUAB703_2","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","1f1e","HISTONE FOLD PROTEIN","Methanopyrus kandleri",3,"VAL A 105;ALA A 104;HIS A  62","None; CL A1001 ( 4.9A);None","0.68A","1q23C-1f1eA:undetectable","1q23C-1f1eA:19.03"],["1Q23_C_FUAC701_1","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","1f1e","HISTONE FOLD PROTEIN","Methanopyrus kandleri",4,"ALA A 100;VAL A 105;ALA A 104;HIS A  62","None;None; CL A1001 ( 4.9A);None","1.12A","1q23A-1f1eA:undetectable","1q23A-1f1eA:19.03"],["1Q23_E_FUAE706_2","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","1f1e","HISTONE FOLD PROTEIN","Methanopyrus kandleri",4,"ALA A 100;VAL A 105;ALA A 104;HIS A  62","None;None; CL A1001 ( 4.9A);None","1.21A","1q23F-1f1eA:undetectable","1q23F-1f1eA:19.03"],["1Q23_G_FUAG708_2","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","1f1e","HISTONE FOLD PROTEIN","Methanopyrus kandleri",3,"VAL A 105;ALA A 104;HIS A  62","None; CL A1001 ( 4.9A);None","0.56A","1q23H-1f1eA:undetectable","1q23H-1f1eA:19.03"],["1Q23_I_FUAI707_1","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","1f1e","HISTONE FOLD PROTEIN","Methanopyrus kandleri",3,"VAL A 105;ALA A 104;HIS A  62","None; CL A1001 ( 4.9A);None","0.66A","1q23G-1f1eA:undetectable","1q23G-1f1eA:19.03"],["1Q23_J_FUAJ711_2","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","1f1e","HISTONE FOLD PROTEIN","Methanopyrus kandleri",4,"ALA A 100;VAL A 105;ALA A 104;HIS A  62","None;None; CL A1001 ( 4.9A);None","1.07A","1q23K-1f1eA:undetectable","1q23K-1f1eA:19.03"],["1Q23_L_FUAL710_1","CHLORAMPHENICOL ACETYLTRANSFERASE;CHLORAMPHENICOL ACETYLTRANSFERASE","1f1e","HISTONE FOLD PROTEIN","Methanopyrus kandleri",3,"VAL A 105;ALA A 104;HIS A  62","None; CL A1001 ( 4.9A);None","0.55A","1q23J-1f1eA:undetectable","1q23J-1f1eA:19.03"],["2WEK_A_DIFA1376_1","ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2","1f1e","HISTONE FOLD PROTEIN","Methanopyrus kandleri",4,"TYR A 108;LEU A 107;LEU A  63;ALA A  67","None","0.96A","2wekA-1f1eA:undetectable","2wekA-1f1eA:21.80"],["4M2V_A_BZ1A302_2","CARBONIC ANHYDRASE 2","1f1e","HISTONE FOLD PROTEIN","Methanopyrus kandleri",3,"HIS A  62;VAL A  75;LEU A 107","None","0.68A","4m2vA-1f1eA:undetectable","4m2vA-1f1eA:21.25"],["5IH0_A_ACTA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE II","1f1e","HISTONE FOLD PROTEIN","Methanopyrus kandleri",4,"PHE A  34;PRO A  36;THR A 116;ILE A  31","None","1.31A","5ih0A-1f1eA:undetectable","5ih0A-1f1eA:22.07"]]