SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f1x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 12 VAL A  24
LEU A  74
LEU A 312
LEU A 314
GLU A 127
None
1.08A 1kw0A-1f1xA:
undetectable
1kw0A-1f1xA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 12 VAL A  24
LEU A  74
LEU A 312
LEU A 314
GLU A 127
None
1.12A 1mmkA-1f1xA:
undetectable
1mmkA-1f1xA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
3 / 3 THR A 219
LEU A 150
LEU A  64
None
0.44A 1mz9C-1f1xA:
undetectable
1mz9C-1f1xA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 12 GLY A 174
ASP A 172
ASP A  14
PRO A  13
PHE A 128
None
1.08A 2f8lA-1f1xA:
undetectable
2f8lA-1f1xA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
4 / 8 ASP A 272
ASP A 154
SER A 251
HIS A 248
None
None
FEL  A 500 ( 4.3A)
FEL  A 500 ( 4.8A)
0.84A 2q0iA-1f1xA:
undetectable
2q0iA-1f1xA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
3 / 3 ARG A 211
THR A 205
VAL A 159
None
0.94A 2q64A-1f1xA:
0.0
2q64A-1f1xA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
4 / 6 THR A 198
VAL A 199
GLU A 267
SER A 251
None
None
FEL  A 500 (-2.4A)
FEL  A 500 ( 4.3A)
1.19A 3b6rB-1f1xA:
undetectable
3b6rB-1f1xA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
4 / 8 TYR A 255
SER A 251
HIS A 214
ARG A 243
None
FEL  A 500 ( 4.3A)
FEL  A 500 (-3.3A)
None
1.04A 3b9lA-1f1xA:
0.0
3b9lA-1f1xA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
3 / 3 ASN A 263
HIS A 264
VAL A  25
None
0.87A 3elzB-1f1xA:
0.0
3elzB-1f1xA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UGR_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
4 / 7 ASN A 280
GLU A 179
GLN A 182
TYR A 273
None
1.17A 3ugrA-1f1xA:
undetectable
3ugrA-1f1xA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
4 / 6 GLU A 127
PHE A  79
TYR A  20
PHE A 129
None
1.10A 4a97E-1f1xA:
0.0
4a97E-1f1xA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 11 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
0.60A 4ir0A-1f1xA:
7.4
4ir0B-1f1xA:
7.6
4ir0A-1f1xA:
19.51
4ir0B-1f1xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IR0_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 11 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
0.55A 4ir0A-1f1xA:
7.4
4ir0B-1f1xA:
7.6
4ir0A-1f1xA:
19.51
4ir0B-1f1xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 12 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
0.54A 4jd1A-1f1xA:
7.5
4jd1B-1f1xA:
7.4
4jd1A-1f1xA:
19.51
4jd1B-1f1xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JD1_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB 2)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 12 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
0.67A 4jd1A-1f1xA:
7.5
4jd1B-1f1xA:
7.4
4jd1A-1f1xA:
19.51
4jd1B-1f1xA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
3 / 3 ASP A 260
LEU A  39
VAL A  43
None
0.71A 4jecB-1f1xA:
0.0
4jecB-1f1xA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 12 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
0.53A 4jh3A-1f1xA:
7.1
4jh3B-1f1xA:
7.6
4jh3A-1f1xA:
18.01
4jh3B-1f1xA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH3_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 11 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
0.51A 4jh3A-1f1xA:
7.1
4jh3B-1f1xA:
7.6
4jh3A-1f1xA:
18.01
4jh3B-1f1xA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 11 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
0.45A 4jh4A-1f1xA:
7.6
4jh4B-1f1xA:
7.4
4jh4A-1f1xA:
18.01
4jh4B-1f1xA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH4_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 11 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
0.47A 4jh4A-1f1xA:
7.6
4jh4B-1f1xA:
7.4
4jh4A-1f1xA:
18.01
4jh4B-1f1xA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 11 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
0.49A 4jh5A-1f1xA:
7.6
4jh5B-1f1xA:
7.3
4jh5A-1f1xA:
18.01
4jh5B-1f1xA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH5_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 11 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
0.50A 4jh5A-1f1xA:
7.6
4jh5B-1f1xA:
7.3
4jh5A-1f1xA:
18.01
4jh5B-1f1xA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_A_FCNA202_1
(METALLOTHIOL
TRANSFERASE FOSB)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 10 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
0.52A 4jh6A-1f1xA:
7.6
4jh6B-1f1xA:
7.4
4jh6A-1f1xA:
18.01
4jh6B-1f1xA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH6_B_FCNB202_1
(METALLOTHIOL
TRANSFERASE FOSB)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 10 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
0.53A 4jh6A-1f1xA:
7.6
4jh6B-1f1xA:
7.4
4jh6A-1f1xA:
18.01
4jh6B-1f1xA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_A_FCNA204_1
(METALLOTHIOL
TRANSFERASE FOSB)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 10 HIS A 214
TYR A 257
GLU A 267
HIS A 155
ALA A 203
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
0.50A 4jh8A-1f1xA:
7.6
4jh8B-1f1xA:
7.1
4jh8A-1f1xA:
18.01
4jh8B-1f1xA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JH8_B_FCNB203_1
(METALLOTHIOL
TRANSFERASE FOSB)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 10 HIS A 155
ALA A 203
HIS A 214
TYR A 257
GLU A 267
FEL  A 500 (-3.3A)
FEL  A 500 ( 4.2A)
FEL  A 500 (-3.3A)
FEL  A 500 (-4.7A)
FEL  A 500 (-2.4A)
0.50A 4jh8A-1f1xA:
7.6
4jh8B-1f1xA:
7.1
4jh8A-1f1xA:
18.01
4jh8B-1f1xA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
4 / 7 GLU A  22
ARG A 117
GLU A 127
ALA A  78
None
0.98A 4zz8A-1f1xA:
0.0
4zz8A-1f1xA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
4 / 6 GLY A 249
ASP A 154
ILE A 268
TYR A 257
None
None
None
FEL  A 500 (-4.7A)
0.86A 5iwuA-1f1xA:
undetectable
5iwuA-1f1xA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
3 / 3 THR A 187
PRO A 164
ASP A 162
None
0.88A 5l8dB-1f1xA:
undetectable
5l8dB-1f1xA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
3 / 3 THR A 187
PRO A 164
ASP A 162
None
0.88A 5mwuB-1f1xA:
undetectable
5mwuB-1f1xA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
4 / 6 LEU A 170
VAL A 177
THR A 282
LEU A 204
None
0.99A 5tudD-1f1xA:
0.0
5tudD-1f1xA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 8 ARG A 292
ALA A 190
VAL A 163
THR A 187
GLY A 206
None
1.35A 5v0vA-1f1xA:
undetectable
5v0vA-1f1xA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
5 / 10 ARG A 117
PRO A 125
GLY A 111
THR A 132
ALA A 115
None
1.17A 5vyhA-1f1xA:
0.0
5vyhA-1f1xA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA608_0
(ALPHA-AMYLASE)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
4 / 6 GLY A 166
GLN A 158
TYR A 126
TYR A 169
None
1.19A 6ag0A-1f1xA:
undetectable
6ag0A-1f1xA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC606_0
(ALPHA-AMYLASE)
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum)
4 / 6 GLY A 166
GLN A 158
TYR A 126
TYR A 169
None
1.21A 6ag0C-1f1xA:
undetectable
6ag0C-1f1xA:
14.24