SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f20'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 7 ASP A1289
PHE A1281
SER A1313
ARG A1314
 None
None
NAP  A1502 (-2.6A)
NAP  A1502 (-4.0A)
 1.18A 1rqpB-1f20A:
3.5		 1rqpB-1f20A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 8 ASP A1289
PHE A1281
SER A1313
ARG A1314
 None
None
NAP  A1502 (-2.6A)
NAP  A1502 (-4.0A)
 1.19A 1rqpC-1f20A:
3.3		 1rqpC-1f20A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB2_2
(CES1 PROTEIN)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 4 LEU A1164
PRO A1104
ILE A1100
LEU A1098
 None
 1.10A 1ya4B-1f20A:
undetectable		 1ya4B-1f20A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 8 ASP A1289
PHE A1281
SER A1313
ARG A1314
 None
None
NAP  A1502 (-2.6A)
NAP  A1502 (-4.0A)
 1.14A 2v7uA-1f20A:
2.1		 2v7uA-1f20A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 7 ASP A1289
PHE A1281
SER A1313
ARG A1314
 None
None
NAP  A1502 (-2.6A)
NAP  A1502 (-4.0A)
 1.15A 2v7uB-1f20A:
3.7		 2v7uB-1f20A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZE2_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		5 / 10 ILE A1362
VAL A1247
TYR A1347
PRO A1243
LEU A1339
 None
 1.25A 2ze2A-1f20A:
0.7		 2ze2A-1f20A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 8 TYR A1347
SER A1258
VAL A1242
CYH A1244
 None
 1.17A 3b9lA-1f20A:
0.0		 3b9lA-1f20A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_A_SAMA220_0
(16S RRNA METHYLASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		5 / 12 GLY A1250
GLY A1282
VAL A1247
ALA A1254
SER A1313
 NAP  A1502 (-3.5A)
None
None
FAD  A1501 ( 3.7A)
NAP  A1502 (-2.6A)
 1.05A 3mteA-1f20A:
4.1		 3mteA-1f20A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		5 / 12 GLY A1250
GLY A1282
VAL A1247
ALA A1254
SER A1313
 NAP  A1502 (-3.5A)
None
None
FAD  A1501 ( 3.7A)
NAP  A1502 (-2.6A)
 1.00A 3p2kD-1f20A:
2.5		 3p2kD-1f20A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		3 / 3 ASN A1078
GLU A1067
ARG A1069
 None
 0.99A 3wxoA-1f20A:
0.0		 3wxoA-1f20A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		3 / 3 ARG A1173
TRP A1214
GLY A1038
 FAD  A1501 (-4.0A)
GOL  A2084 (-4.3A)
GOL  A2084 ( 4.5A)
 1.03A 4e7cA-1f20A:
0.0		 4e7cA-1f20A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7A_A_MXDA1002_1
(ANDROGEN RECEPTOR)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		3 / 3 GLU A1136
TRP A1140
LYS A1130
 None
 1.43A 4k7aA-1f20A:
0.0		 4k7aA-1f20A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA407_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		3 / 3 GLU A1187
ARG A1016
HIS A1189
 None
 0.75A 4kf9A-1f20A:
undetectable		 4kf9A-1f20A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		5 / 9 PRO A1205
LEU A1043
GLU A1151
VAL A1147
THR A1145
 None
 1.46A 4x3mA-1f20A:
undetectable		 4x3mA-1f20A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		5 / 12 ALA A1254
THR A1251
GLY A1030
PRO A1029
SER A1258
 FAD  A1501 ( 3.7A)
NAP  A1502 ( 3.9A)
None
None
None
 1.18A 4ypmA-1f20A:
undetectable		 4ypmA-1f20A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 5 THR A 981
THR A1019
HIS A1189
LEU A1033
 None
 1.29A 5axaC-1f20A:
2.7		 5axaC-1f20A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		5 / 12 GLY A1282
TYR A1322
LEU A1279
GLY A1252
ILE A1253
 None
NAP  A1502 ( 3.4A)
None
None
None
 0.94A 5d4uC-1f20A:
undetectable		 5d4uC-1f20A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		5 / 12 GLY A1282
TYR A1322
LEU A1279
GLY A1252
ILE A1253
 None
NAP  A1502 ( 3.4A)
None
None
None
 0.93A 5d4uD-1f20A:
undetectable		 5d4uD-1f20A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_G_IPHG101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 6 HIS A1391
CYH A1244
HIS A1235
LEU A1236
 None
 1.29A 5hrqD-1f20A:
undetectable
5hrqG-1f20A:
undetectable
5hrqH-1f20A:
undetectable		 5hrqD-1f20A:
7.35
5hrqG-1f20A:
4.43
5hrqH-1f20A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_K_IPHK101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 6 HIS A1391
CYH A1244
HIS A1235
LEU A1236
 None
 1.31A 5hrqH-1f20A:
undetectable
5hrqK-1f20A:
undetectable
5hrqL-1f20A:
undetectable		 5hrqH-1f20A:
7.35
5hrqK-1f20A:
4.43
5hrqL-1f20A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 8 TYR A1175
VAL A1195
ILE A1194
ILE A1218
 FAD  A1501 (-4.3A)
NAP  A1502 ( 4.5A)
None
None
 0.73A 5hw8H-1f20A:
undetectable		 5hw8H-1f20A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 7 LEU A1025
GLY A1021
LEU A1017
ALA A 995
 None
 0.74A 5o96C-1f20A:
2.1		 5o96C-1f20A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 8 VAL A1061
LEU A1164
THR A1161
ALA A1160
 None
 0.77A 5tt3H-1f20A:
undetectable		 5tt3H-1f20A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		6 / 9 SER A1176
THR A1251
GLY A1252
ALA A1254
CYH A1349
GLY A1350
 FAD  A1501 (-3.7A)
NAP  A1502 ( 3.9A)
None
FAD  A1501 ( 3.7A)
None
None
 0.56A 5vw4A-1f20A:
29.1		 5vw4A-1f20A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		5 / 8 SER A1176
THR A1251
GLY A1252
CYH A1349
GLY A1350
 FAD  A1501 (-3.7A)
NAP  A1502 ( 3.9A)
None
None
None
 0.51A 5vw5A-1f20A:
29.2		 5vw5A-1f20A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		6 / 8 SER A1176
THR A1251
GLY A1252
ALA A1254
CYH A1349
GLY A1350
 FAD  A1501 (-3.7A)
NAP  A1502 ( 3.9A)
None
FAD  A1501 ( 3.7A)
None
None
 0.58A 5vw9A-1f20A:
29.7		 5vw9A-1f20A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_A_PA1A206_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 4 TYR A1175
GLY A1038
ASN A1039
ARG A1173
 FAD  A1501 (-4.3A)
GOL  A2084 ( 4.5A)
None
FAD  A1501 (-4.0A)
 1.40A 5w7bA-1f20A:
0.0
5w7bC-1f20A:
0.2		 5w7bA-1f20A:
10.89
5w7bC-1f20A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6J_A_ACTA404_0
(L-LYSINE
3-HYDROXYLASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		4 / 6 ILE A1177
TYR A1027
ARG A1257
SER A1258
 None
 1.23A 6f6jA-1f20A:
0.0		 6f6jA-1f20A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 1f20 NITRIC-OXIDE
SYNTHASE
(Rattus
norvegicus) 		3 / 3 ILE A1090
THR A1089
PRO A1055
 None
 0.48A 6ncsA-1f20A:
undetectable		 6ncsA-1f20A:
20.80