SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f2d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSG_B_MK1B902_2
(HIV-1 PROTEASE)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		5 / 12 GLY A 212
ALA A 179
ASP A 180
GLY A 174
VAL A 198
 None
 1.00A 1hsgB-1f2dA:
undetectable		 1hsgB-1f2dA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		5 / 11 GLU A  39
ASP A 180
GLY A 177
PHE A 175
MET A 213
 None
 1.14A 1hvyC-1f2dA:
0.0		 1hvyC-1f2dA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_C_D16C416_1
(THYMIDYLATE SYNTHASE)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		5 / 11 GLU A  39
GLY A 177
PHE A 175
TYR A 216
MET A 213
 None
 1.38A 1hvyC-1f2dA:
0.0		 1hvyC-1f2dA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		5 / 12 LEU A  55
LEU A  11
SER A  43
ALA A  85
ALA A 127
 None
 1.11A 2bm9D-1f2dA:
2.3		 2bm9D-1f2dA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FQY_A_ADNA400_1
(MEMBRANE LIPOPROTEIN
TMPC)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		5 / 12 ASN A 118
GLY A 325
ASP A 292
GLY A  75
VAL A 103
 None
PLP  A 342 (-3.6A)
PLP  A 342 ( 4.5A)
None
None
 1.26A 2fqyA-1f2dA:
2.1		 2fqyA-1f2dA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		5 / 12 LEU A 290
ILE A 280
ARG A 281
PHE A 336
GLY A 324
 None
None
None
None
PLP  A 342 (-4.0A)
 1.23A 2lbdA-1f2dA:
undetectable		 2lbdA-1f2dA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		4 / 4 ARG A  53
GLY A  49
GLU A  39
SER A  72
 None
 1.36A 2xctS-1f2dA:
0.1
2xctU-1f2dA:
undetectable		 2xctS-1f2dA:
20.60
2xctU-1f2dA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y4N_B_PACB503_0
(PHENYLACETATE-COENZY
ME A LIGASE)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		4 / 4 SER A  78
GLY A 324
GLY A  49
LYS A  51
 SO4  A 940 (-2.7A)
PLP  A 342 (-4.0A)
None
PLP  A 342 ( 1.3A)
 1.39A 2y4nB-1f2dA:
1.0		 2y4nB-1f2dA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		4 / 8 ASP A 101
GLY A  75
GLU A 133
ARG A 123
 None
 0.92A 3s3mA-1f2dA:
undetectable		 3s3mA-1f2dA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		3 / 3 LYS A  54
SER A  72
GLN A  80
 PLP  A 342 (-2.7A)
None
None
 1.31A 3si7A-1f2dA:
undetectable		 3si7A-1f2dA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		5 / 12 GLN A 237
GLY A 139
ILE A  58
GLY A 164
ALA A 163
 None
 1.13A 3sudB-1f2dA:
undetectable		 3sudB-1f2dA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		5 / 12 GLY A 172
GLY A 208
THR A 245
LEU A 248
TYR A  57
 None
 1.13A 4f84A-1f2dA:
undetectable		 4f84A-1f2dA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G10_A_ACTA301_0
(GLUTATHIONE
S-TRANSFERASE
HOMOLOG)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		4 / 6 ILE A 138
TYR A 295
TYR A 269
PHE A 136
 None
PLP  A 342 ( 4.1A)
None
None
 1.18A 4g10A-1f2dA:
0.0		 4g10A-1f2dA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		3 / 3 SER A 299
TYR A 320
ASP A 292
 None
None
PLP  A 342 ( 4.5A)
 0.80A 4rp8C-1f2dA:
0.0		 4rp8C-1f2dA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		5 / 12 THR A 202
GLN A  80
THR A  81
VAL A  84
GLU A 100
 PLP  A 342 (-2.9A)
None
None
None
None
 1.15A 4s0vA-1f2dA:
undetectable		 4s0vA-1f2dA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		3 / 3 ARG A 263
ASP A 261
TYR A 311
 None
 0.76A 4yo9B-1f2dA:
undetectable		 4yo9B-1f2dA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		4 / 7 ALA A 242
ASP A 221
ARG A 218
GLY A 217
 None
 1.01A 5bs8A-1f2dA:
0.0
5bs8B-1f2dA:
undetectable
5bs8C-1f2dA:
0.0		 5bs8A-1f2dA:
21.16
5bs8B-1f2dA:
23.62
5bs8C-1f2dA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		4 / 5 SER A  72
ARG A  53
GLY A  49
GLU A  39
 None
 1.16A 5cdqA-1f2dA:
0.0
5cdqB-1f2dA:
undetectable
5cdqC-1f2dA:
0.0		 5cdqA-1f2dA:
22.80
5cdqB-1f2dA:
19.88
5cdqC-1f2dA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		4 / 5 SER A  72
ARG A  53
GLY A  49
GLU A  39
 None
 1.16A 5cdqR-1f2dA:
0.0
5cdqS-1f2dA:
undetectable
5cdqT-1f2dA:
0.0		 5cdqR-1f2dA:
22.80
5cdqS-1f2dA:
19.88
5cdqT-1f2dA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		4 / 8 VAL A 182
GLU A  39
GLY A 177
GLY A 208
 None
 0.79A 5e26C-1f2dA:
2.0
5e26D-1f2dA:
2.0		 5e26C-1f2dA:
21.63
5e26D-1f2dA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		5 / 10 ILE A 138
GLY A 203
THR A 205
PHE A 136
LEU A 323
 None
PLP  A 342 (-3.9A)
PLP  A 342 (-3.4A)
None
PLP  A 342 (-3.9A)
 1.13A 5fhzC-1f2dA:
2.1		 5fhzC-1f2dA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC609_0
(ALPHA-AMYLASE)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		4 / 7 LYS A  54
GLY A 164
ASP A 137
MET A 140
 PLP  A 342 (-2.7A)
None
None
None
 1.34A 6ag0C-1f2dA:
undetectable		 6ag0C-1f2dA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BP4_A_SAMA505_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		3 / 3 ILE A 225
ASN A 273
CYH A 268
 None
 0.87A 6bp4A-1f2dA:
0.0		 6bp4A-1f2dA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		3 / 3 ASP A 257
ASP A 261
ASN A 273
 None
 0.78A 6gngB-1f2dA:
undetectable		 6gngB-1f2dA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCX_A_ZMRA519_1
(NEURAMINIDASE)		 1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE
(Cyberlindnera
saturnus) 		3 / 3 TRP A 102
ILE A  73
GLU A 167
 None
 0.81A 6hcxA-1f2dA:
undetectable		 6hcxA-1f2dA:
12.08