SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f2e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 8 LEU A 140
GLY A 148
LEU A 158
TYR A 181
 None
 0.95A 1jlbA-1f2eA:
undetectable		 1jlbA-1f2eA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 12 GLY A   8
ALA A  13
SER A  11
HIS A 106
LEU A 101
 None
None
None
GSH  A 210 (-4.4A)
None
 1.11A 1kiaD-1f2eA:
0.0		 1kiaD-1f2eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 12 GLY A   8
ALA A  13
SER A  11
HIS A 106
LEU A 101
 None
None
None
GSH  A 210 (-4.4A)
None
 1.07A 1nbhB-1f2eA:
undetectable		 1nbhB-1f2eA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 12 LEU A  44
ASN A  47
ALA A  54
SER A   6
LEU A  32
 None
None
None
None
GSH  A 210 ( 3.9A)
 1.43A 1ya3B-1f2eA:
0.2		 1ya3B-1f2eA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		5 / 12 LEU A  12
TYR A 181
ALA A 166
GLY A 183
ALA A 186
 None
 0.96A 3ln1C-1f2eA:
0.0		 3ln1C-1f2eA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA206_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 4 ALA A 190
ALA A 193
ALA A 194
ALA A 197
 None
 0.09A 4oadA-1f2eA:
0.0		 4oadA-1f2eA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 4 ALA A 190
ALA A 193
ALA A 194
ALA A 197
 None
 0.11A 4oaeA-1f2eA:
0.0		 4oaeA-1f2eA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 6 ILE A 185
PHE A 151
ILE A  16
GLU A  20
 None
 1.01A 4zzcA-1f2eA:
3.0
4zzcB-1f2eA:
2.9		 4zzcA-1f2eA:
23.58
4zzcB-1f2eA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 7 ILE A   5
VAL A 168
ASN A  66
PHE A 109
 None
None
GSH  A 210 (-4.1A)
None
 0.93A 5hieC-1f2eA:
0.0		 5hieC-1f2eA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 6 ALA A 154
LEU A 158
TYR A 181
SER A 152
 None
 1.12A 5phhA-1f2eA:
undetectable		 5phhA-1f2eA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 1f2e GLUTATHIONE
S-TRANSFERASE
(Sphingomonas
paucimobilis) 		4 / 6 PHE A  25
LEU A   3
ALA A  27
SER A  11
 None
 0.95A 6f88A-1f2eA:
undetectable		 6f88A-1f2eA:
16.10