SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f2h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 6 HIS A  65
ILE A  64
ALA A  31
VAL A  41
 None
 0.99A 1hk1A-1f2hA:
undetectable		 1hk1A-1f2hA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN
(Homo
sapiens) 		5 / 9 CYH A  83
LEU A  75
ALA A  15
LEU A  17
LEU A 118
 None
 1.42A 1hwiA-1f2hA:
2.7		 1hwiA-1f2hA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_C_DIFC2701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN
(Homo
sapiens) 		5 / 12 VAL A  58
LEU A  59
SER A  55
LEU A  87
GLY A  84
 None
 0.92A 1pxxC-1f2hA:
0.0		 1pxxC-1f2hA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA310_1
(BETA-LACTAMASE)		 1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN
(Homo
sapiens) 		4 / 8 ARG A  43
ALA A  40
GLY A  54
PRO A  56
 None
 0.90A 3ny4A-1f2hA:
undetectable		 3ny4A-1f2hA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 125
GLY A  84
ALA A  89
LEU A 129
GLY A  54
 None
 0.91A 4dc3A-1f2hA:
undetectable		 4dc3A-1f2hA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 126
ARG A 124
ASP A 131
 None
 0.88A 4fp9F-1f2hA:
undetectable		 4fp9F-1f2hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN
(Homo
sapiens) 		5 / 12 VAL A  58
LEU A  59
SER A  55
LEU A  87
GLY A  84
 None
 1.01A 4rrwC-1f2hA:
undetectable		 4rrwC-1f2hA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN
(Homo
sapiens) 		5 / 12 VAL A  58
LEU A  59
SER A  55
LEU A  87
GLY A  84
 None
 1.01A 4rrzC-1f2hA:
undetectable		 4rrzC-1f2hA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN
(Homo
sapiens) 		3 / 3 LEU A 118
ASP A 126
ILE A  72
 None
 0.65A 4xi3D-1f2hA:
undetectable		 4xi3D-1f2hA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN
(Homo
sapiens) 		3 / 3 ALA A 158
ASN A 161
LEU A 162
 None
 0.52A 5i1nC-1f2hA:
0.0		 5i1nC-1f2hA:
12.68