SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f2j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 TRP A 323
ALA A 332
VAL A 330
 None
 0.98A 2izqC-1f2jA:
undetectable
2izqD-1f2jA:
undetectable		 2izqC-1f2jA:
3.96
2izqD-1f2jA:
3.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 9 THR A 278
LEU A 237
VAL A 193
THR A  28
VAL A 112
 None
 1.38A 2l8mA-1f2jA:
0.0		 2l8mA-1f2jA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 5 VAL A 223
VAL A 231
GLY A 230
TRP A 233
 None
 0.96A 2p2fA-1f2jA:
2.2		 2p2fA-1f2jA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 5 GLN A 216
THR A 265
ARG A 268
ALA A 267
 None
 1.14A 2qhfA-1f2jA:
0.0		 2qhfA-1f2jA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 PHE A 154
SER A 310
LEU A  40
 None
 0.78A 2w1bA-1f2jA:
0.0		 2w1bA-1f2jA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 THR A 308
GLY A  38
ALA A  34
ALA A  41
ASP A  43
 None
 1.12A 2yvlD-1f2jA:
undetectable		 2yvlD-1f2jA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 GLY A 191
PRO A 194
VAL A 193
ALA A 184
LEU A  17
 None
 0.97A 3mteB-1f2jA:
undetectable		 3mteB-1f2jA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 GLU A 197
LEU A 280
LEU A  40
 None
 0.75A 3ohtB-1f2jA:
undetectable		 3ohtB-1f2jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OOI_A_SAMA237_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ARG A  65
GLY A  47
ASN A  60
HIS A  64
LEU A  58
 None
 1.32A 3ooiA-1f2jA:
undetectable		 3ooiA-1f2jA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 GLY A 191
PRO A 194
VAL A 193
ALA A 184
LEU A  17
 None
 0.97A 3p2kC-1f2jA:
undetectable		 3p2kC-1f2jA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 GLY A 191
PRO A 194
VAL A 193
ALA A 184
LEU A  17
 None
 0.97A 3p2kD-1f2jA:
undetectable		 3p2kD-1f2jA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 GLY A 230
TYR A  14
GLU A  22
ALA A 184
LEU A 226
 None
 1.17A 3vywA-1f2jA:
undetectable		 3vywA-1f2jA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 GLY A 276
ILE A 270
VAL A 269
ASN A 241
LEU A 307
 None
 1.23A 4a81A-1f2jA:
undetectable		 4a81A-1f2jA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 7 VAL A 112
PHE A  78
ILE A  82
PHE A 337
 None
 0.77A 4fglC-1f2jA:
undetectable		 4fglC-1f2jA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 5 LEU A 280
SER A 310
ASP A  43
ASP A  89
 None
 1.28A 4qtuD-1f2jA:
undetectable		 4qtuD-1f2jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 LEU A 186
GLY A 235
PRO A 275
LEU A 274
ARG A 182
 None
 1.22A 4x61A-1f2jA:
2.5		 4x61A-1f2jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 GLY A  84
VAL A 111
VAL A  85
MET A  72
LEU A  73
 None
 1.31A 4yb6A-1f2jA:
0.0
4yb6E-1f2jA:
0.0		 4yb6A-1f2jA:
23.50
4yb6E-1f2jA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 MET A  72
LEU A  73
GLY A  84
VAL A 111
VAL A  85
 None
 1.31A 4yb6B-1f2jA:
0.0
4yb6F-1f2jA:
0.0		 4yb6B-1f2jA:
23.50
4yb6F-1f2jA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YNM_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 GLY A 136
HIS A  88
TYR A 147
CYH A 155
ILE A 115
 None
 1.32A 4ynmB-1f2jA:
undetectable		 4ynmB-1f2jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		4 / 8 ASN A 241
PRO A 240
PHE A 279
SER A 281
 None
 1.42A 5amiB-1f2jA:
0.0		 5amiB-1f2jA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 LEU A 186
GLY A 235
PRO A 275
LEU A 274
ARG A 182
 None
 1.21A 5emlA-1f2jA:
5.3		 5emlA-1f2jA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_A_REAA602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ILE A 320
GLY A 324
ASN A  60
PHE A  53
LEU A  58
 None
 1.41A 5fhzA-1f2jA:
undetectable		 5fhzA-1f2jA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		3 / 3 LEU A  87
LEU A  73
ARG A 313
 None
 0.61A 5hnzB-1f2jA:
undetectable		 5hnzB-1f2jA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_A_SAMA801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ILE A  86
THR A 117
ASP A 118
CYH A 155
LEU A  39
 None
 0.97A 5hw4A-1f2jA:
undetectable		 5hw4A-1f2jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW4_C_SAMC801_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE I)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 12 ILE A  86
THR A 117
ASP A 118
CYH A 155
LEU A  39
 None
 0.94A 5hw4C-1f2jA:
0.2		 5hw4C-1f2jA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 9 LEU A  25
PRO A 194
VAL A 231
LEU A  17
ARG A  16
 None
 1.29A 5o96E-1f2jA:
undetectable
5o96F-1f2jA:
0.0		 5o96E-1f2jA:
21.61
5o96F-1f2jA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 9 PRO A 194
SER A 187
VAL A 231
LEU A  17
ARG A  16
 None
 1.28A 5o96E-1f2jA:
undetectable
5o96F-1f2jA:
0.0		 5o96E-1f2jA:
21.61
5o96F-1f2jA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL
(Trypanosoma
brucei) 		5 / 10 HIS A 227
VAL A 223
LEU A 274
ALA A 273
PRO A 275
 None
 1.23A 5tt3A-1f2jA:
undetectable		 5tt3A-1f2jA:
18.30