SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f2p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 10 GLY A 101
PHE A 159
SER A 100
LEU A 261
THR A 220
 None
 1.49A 1a8uA-1f2pA:
3.1		 1a8uA-1f2pA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 10 GLY A 101
PHE A 159
SER A 100
LEU A 261
THR A 220
 None
 1.47A 1a8uB-1f2pA:
4.2		 1a8uB-1f2pA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK9_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 10 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.09A 1fk9A-1f2pA:
undetectable		 1fk9A-1f2pA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 11 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.14A 1fkpA-1f2pA:
undetectable		 1fkpA-1f2pA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 9 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.16A 1ikvA-1f2pA:
undetectable		 1ikvA-1f2pA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 10 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.20A 1ikwA-1f2pA:
undetectable		 1ikwA-1f2pA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		4 / 7 LEU A 153
VAL A 211
TYR A 156
GLY A 212
 None
 1.02A 1lweA-1f2pA:
0.0		 1lweA-1f2pA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 9 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.16A 1lwfA-1f2pA:
0.0		 1lwfA-1f2pA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 9 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.24A 1vrtA-1f2pA:
0.0		 1vrtA-1f2pA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		4 / 7 PHE A 159
ALA A 271
ALA A  82
PHE A 125
 None
 1.07A 2vcvA-1f2pA:
0.0		 2vcvA-1f2pA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		4 / 7 PHE A 159
ALA A 271
ALA A  82
PHE A 125
 None
 0.98A 2vcvL-1f2pA:
0.0		 2vcvL-1f2pA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 12 PRO A 167
THR A 220
ASN A 255
LEU A 218
THR A 108
 None
 1.23A 3a50E-1f2pA:
undetectable		 3a50E-1f2pA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		4 / 5 SER A 203
LEU A  86
GLY A 101
GLU A 131
 PHE  A 903 ( 3.9A)
None
None
PHE  A 903 (-2.8A)
 1.18A 3aiaA-1f2pA:
undetectable
3aiaB-1f2pA:
0.3		 3aiaA-1f2pA:
16.49
3aiaB-1f2pA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		6 / 11 GLY A  83
ALA A  82
ILE A 178
GLY A 155
LEU A 153
ILE A 272
 None
 1.45A 3em4A-1f2pA:
undetectable		 3em4A-1f2pA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 12 GLY A  64
GLY A 137
ALA A  62
GLY A  61
ILE A 136
 None
 1.13A 3ku1G-1f2pA:
undetectable		 3ku1G-1f2pA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 12 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.13A 3mecA-1f2pA:
undetectable		 3mecA-1f2pA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MED_A_65BA561_0
(P51 REVERSE
TRANSCRIPTASE
P66 REVERSE
TRANSCRIPTASE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 12 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.18A 3medA-1f2pA:
0.0
3medB-1f2pA:
0.0		 3medA-1f2pA:
20.43
3medB-1f2pA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 11 HIS A  85
ASP A  97
GLU A 131
GLU A 132
HIS A 247
 ZN  A 901 ( 3.3A)
ZN  A 902 (-2.5A)
PHE  A 903 (-2.8A)
ZN  A 902 ( 2.2A)
ZN  A 902 ( 3.3A)
 0.38A 4pqaA-1f2pA:
22.8		 4pqaA-1f2pA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PUO_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		4 / 8 VAL A 213
VAL A  79
TYR A 156
TRP A 128
 None
 0.86A 4puoC-1f2pA:
undetectable		 4puoC-1f2pA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		4 / 8 VAL A 213
VAL A  79
TYR A 156
TRP A 128
 None
 0.92A 4pwdA-1f2pA:
undetectable		 4pwdA-1f2pA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		4 / 5 GLY A  64
THR A  63
HIS A  29
GLY A  60
 None
 1.04A 4v20A-1f2pA:
0.0		 4v20A-1f2pA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 12 SER A 102
GLY A  99
LEU A  16
ARG A  27
ILE A 136
 None
 1.36A 5fepA-1f2pA:
undetectable		 5fepA-1f2pA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 12 SER A 102
GLY A  99
LEU A  16
ARG A  27
ILE A 136
 None
 1.36A 5fesA-1f2pA:
undetectable		 5fesA-1f2pA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		4 / 8 LEU A 218
ASN A 264
SER A 265
ALA A 104
 None
 0.76A 5xu8A-1f2pA:
undetectable		 5xu8A-1f2pA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 10 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.35A 6bsiA-1f2pA:
undetectable		 6bsiA-1f2pA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		5 / 10 LEU A 153
VAL A 211
TYR A 156
GLY A 212
LEU A 145
 None
 1.34A 6bsjA-1f2pA:
0.0		 6bsjA-1f2pA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 1f2p AMINOPEPTIDASE
(Streptomyces
griseus) 		4 / 7 SER A 102
GLY A  94
ALA A  93
LEU A 253
 None
 0.80A 6dwnB-1f2pA:
0.0		 6dwnB-1f2pA:
14.18