SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f45'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1f45 INTERLEUKIN-12 ALPHA
CHAIN
(Homo
sapiens) 		3 / 3 LEU B  23
VAL B  26
LEU B  30
 None
 0.52A 1mz9B-1f45B:
undetectable		 1mz9B-1f45B:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 1f45 INTERLEUKIN-12 ALPHA
CHAIN
(Homo
sapiens) 		5 / 12 LEU B 177
TYR B 112
ALA B 184
MET B  29
LEU B  30
 None
 1.23A 4j7xB-1f45B:
undetectable		 4j7xB-1f45B:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1f45 INTERLEUKIN-12 ALPHA
CHAIN
(Homo
sapiens) 		3 / 3 VAL B 190
SER B 104
MET B 145
 None
 0.91A 5ikqA-1f45B:
undetectable		 5ikqA-1f45B:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_A_ACTA803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1f45 INTERLEUKIN-12 ALPHA
CHAIN
(Homo
sapiens) 		4 / 4 GLU B  67
PRO B  65
ILE B  82
LEU B  66
 None
 1.26A 5m45A-1f45B:
undetectable		 5m45A-1f45B:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_D_ACTD803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1f45 INTERLEUKIN-12 ALPHA
CHAIN
(Homo
sapiens) 		4 / 4 GLU B  67
PRO B  65
ILE B  82
LEU B  66
 None
 1.20A 5m45D-1f45B:
undetectable		 5m45D-1f45B:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_G_ACTG803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1f45 INTERLEUKIN-12 ALPHA
CHAIN
(Homo
sapiens) 		4 / 4 GLU B  67
PRO B  65
ILE B  82
LEU B  66
 None
 1.25A 5m45G-1f45B:
undetectable		 5m45G-1f45B:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 1f45 INTERLEUKIN-12 ALPHA
CHAIN
(Homo
sapiens) 		4 / 4 GLU B  67
PRO B  65
ILE B  82
LEU B  66
 None
 1.20A 5m45J-1f45B:
undetectable		 5m45J-1f45B:
12.24