SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f4h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 7 HIS A 972
GLY A 589
GLY A 590
GLN A 600
 None
 0.98A 1ekjE-1f4hA:
undetectable
1ekjF-1f4hA:
undetectable		 1ekjE-1f4hA:
11.89
1ekjF-1f4hA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 PHE A 176
GLY A 156
LEU A  74
LEU A   7
VAL A  10
 None
 1.26A 1gseA-1f4hA:
0.0		 1gseA-1f4hA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 6 ALA A  29
ILE A 142
PRO A 168
GLU A 170
 None
 1.26A 1oniB-1f4hA:
0.0
1oniC-1f4hA:
0.0		 1oniB-1f4hA:
9.20
1oniC-1f4hA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 6 ARG A 857
ALA A 833
ILE A 749
PRO A 738
 None
 1.28A 1oniB-1f4hA:
0.0
1oniC-1f4hA:
0.0		 1oniB-1f4hA:
9.20
1oniC-1f4hA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 LEU A  74
GLU A  71
VAL A  10
LEU A 189
PHE A  63
 None
 1.17A 1s9pB-1f4hA:
undetectable		 1s9pB-1f4hA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_C_CRNC4401_1
(CREATININE
AMIDOHYDROLASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 HIS A 972
ASP A 591
TYR A 100
TRP A 203
 None
 0.95A 1v7zC-1f4hA:
undetectable		 1v7zC-1f4hA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_D_CRND5401_1
(CREATININE
AMIDOHYDROLASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 HIS A 972
ASP A 591
TYR A 100
TRP A 203
 None
 0.97A 1v7zD-1f4hA:
undetectable		 1v7zD-1f4hA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_E_CRNE6401_1
(CREATININE
AMIDOHYDROLASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 HIS A 972
ASP A 591
TYR A 100
TRP A 203
 None
 0.96A 1v7zE-1f4hA:
undetectable		 1v7zE-1f4hA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V7Z_F_CRNF7401_1
(CREATININE
AMIDOHYDROLASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 HIS A 972
ASP A 591
TYR A 100
TRP A 203
 None
 0.96A 1v7zF-1f4hA:
undetectable		 1v7zF-1f4hA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 5 GLY A 194
PRO A 111
VAL A 109
ILE A 107
 None
 0.92A 2aoiA-1f4hA:
undetectable		 2aoiA-1f4hA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 LYS A1023
ASP A 919
ASP A 924
 None
 1.08A 2br4A-1f4hA:
2.1		 2br4A-1f4hA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 PHE A1007
GLY A 994
GLY A 995
ALA A 539
PRO A 907
 None
 1.14A 2dpmA-1f4hA:
undetectable		 2dpmA-1f4hA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 ASN A 935
ASN A 544
ARG A 909
 None
 0.91A 2rlcA-1f4hA:
0.0		 2rlcA-1f4hA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 7 PHE A 235
ILE A 455
ILE A 534
GLY A 346
 None
 0.96A 2v0mB-1f4hA:
0.0		 2v0mB-1f4hA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		6 / 12 ASP A 201
ASN A 460
TYR A 503
GLU A 537
TRP A 568
ASN A 102
 None
None
None
None
None
MG  A3001 (-4.1A)
 1.40A 2v3dA-1f4hA:
13.1		 2v3dA-1f4hA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		6 / 11 ASP A 201
ASN A 460
TYR A 503
GLU A 537
TRP A 568
ASN A 102
 None
None
None
None
None
MG  A3001 (-4.1A)
 1.46A 2v3dB-1f4hA:
4.1		 2v3dB-1f4hA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 7 TRP A 191
VAL A 114
TYR A 105
TYR A 196
 None
 1.16A 2xz5B-1f4hA:
0.0
2xz5E-1f4hA:
0.0		 2xz5B-1f4hA:
11.67
2xz5E-1f4hA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 TRP A 191
VAL A 114
TYR A 105
TYR A 196
 None
 1.19A 2xz5A-1f4hA:
undetectable
2xz5C-1f4hA:
0.0		 2xz5A-1f4hA:
11.67
2xz5C-1f4hA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 TRP A 191
VAL A 114
TYR A 105
TYR A 196
 None
 1.20A 2xz5C-1f4hA:
0.0
2xz5D-1f4hA:
0.0		 2xz5C-1f4hA:
11.67
2xz5D-1f4hA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 7 TRP A 191
VAL A 114
TYR A 105
TYR A 196
 None
 1.17A 2xz5D-1f4hA:
0.0
2xz5E-1f4hA:
0.0		 2xz5D-1f4hA:
11.67
2xz5E-1f4hA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 TYR A 642
GLU A 650
THR A 706
 None
 0.78A 2y7hB-1f4hA:
0.9		 2y7hB-1f4hA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARQ_A_DM5A606_1
(CHITINASE A)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 6 ASP A 375
TRP A 398
TYR A 405
ARG A 356
 None
 1.34A 3arqA-1f4hA:
undetectable		 3arqA-1f4hA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 GLY A 489
GLY A 465
GLY A 463
 None
 0.34A 3bogC-1f4hA:
0.0		 3bogC-1f4hA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 ARG A 352
GLU A 650
ASP A 671
 None
 0.84A 3g2oA-1f4hA:
undetectable		 3g2oA-1f4hA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 ASN A  55
GLY A  56
VAL A  84
LEU A 184
ILE A 208
 None
 1.21A 3h52A-1f4hA:
undetectable		 3h52A-1f4hA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 GLY A 794
ARG A 786
ASP A 908
ASP A 997
GLY A 547
 None
 1.28A 3jzjA-1f4hA:
0.0		 3jzjA-1f4hA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 ASP A 164
ARG A 439
ARG A 210
 None
 1.00A 3k37A-1f4hA:
undetectable		 3k37A-1f4hA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_A_AC2A301_1
(DEOXYCYTIDINE KINASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 9 ILE A 793
GLU A 797
ARG A 599
ASP A 598
PHE A 601
 None
 1.36A 3mjrA-1f4hA:
0.0		 3mjrA-1f4hA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 ASP A 610
ALA A 609
SER A 574
SER A 586
 None
 1.00A 3rodA-1f4hA:
undetectable		 3rodA-1f4hA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_B_DXCB92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 5 VAL A 571
VAL A 607
ARG A 611
LYS A 621
 None
 1.43A 3rv5A-1f4hA:
undetectable
3rv5B-1f4hA:
undetectable		 3rv5A-1f4hA:
6.82
3rv5B-1f4hA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 LEU A 937
LEU A 910
GLY A 988
GLN A 956
PHE A 955
 None
 1.25A 3tbgA-1f4hA:
0.0		 3tbgA-1f4hA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 LEU A 937
LEU A 910
GLY A 988
GLN A 956
PHE A 955
 None
 1.23A 3tbgC-1f4hA:
0.0		 3tbgC-1f4hA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 6 GLN A 262
TYR A 309
PHE A 332
LEU A 300
 None
 1.39A 3tgvB-1f4hA:
0.0		 3tgvB-1f4hA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 ARG A  43
ARG A 310
TRP A 261
 None
 1.26A 4b7nA-1f4hA:
undetectable		 4b7nA-1f4hA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 ARG A  43
ARG A 310
TRP A 261
 None
 1.29A 4cpzE-1f4hA:
undetectable		 4cpzE-1f4hA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 ARG A  43
ARG A 310
TRP A 261
 None
 1.31A 4cpzF-1f4hA:
undetectable		 4cpzF-1f4hA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 ARG A  43
ARG A 310
TRP A 261
 None
 1.32A 4cpzG-1f4hA:
undetectable		 4cpzG-1f4hA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 ARG A  43
ARG A 310
TRP A 261
 None
 1.30A 4cpzH-1f4hA:
2.3		 4cpzH-1f4hA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 ASP A 144
ASP A 447
ASP A 411
GLU A 170
 None
 1.12A 4feuD-1f4hA:
0.0		 4feuD-1f4hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 SER A 960
GLU A 934
GLY A 883
ARG A 881
 None
 0.87A 4fgzA-1f4hA:
undetectable
4fgzB-1f4hA:
undetectable		 4fgzA-1f4hA:
13.49
4fgzB-1f4hA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 SER A 462
ASN A 460
CYH A 500
GLY A 490
 None
 1.00A 4fo4A-1f4hA:
9.1		 4fo4A-1f4hA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 7 ILE A 351
LEU A 349
ALA A 386
VAL A 387
 None
 0.71A 4g77A-1f4hA:
undetectable		 4g77A-1f4hA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IP7_D_ADND604_1
(PYRUVATE KINASE
ISOZYMES L)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 ARG A 917
GLU A 943
ASN A 896
 None
 0.91A 4ip7D-1f4hA:
3.9		 4ip7D-1f4hA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 ILE A 498
PHE A 384
LEU A 546
LEU A 606
LEU A 535
 None
 1.02A 4j03A-1f4hA:
undetectable		 4j03A-1f4hA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 11 GLY A 543
ALA A 616
LEU A 606
GLY A 605
ALA A 303
 None
 1.21A 4l6v1-1f4hA:
undetectable
4l6v6-1f4hA:
undetectable		 4l6v1-1f4hA:
21.89
4l6v6-1f4hA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A502_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 ASP A 224
GLU A 243
VAL A 444
THR A 441
 None
 1.16A 4lnwA-1f4hA:
undetectable		 4lnwA-1f4hA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 7 HIS A 395
PRO A 396
PHE A 209
ASP A 144
 None
 1.27A 4ndnC-1f4hA:
undetectable		 4ndnC-1f4hA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 7 HIS A 395
PRO A 396
PHE A 209
ASP A 144
 None
 1.26A 4odjA-1f4hA:
undetectable		 4odjA-1f4hA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 GLY A 543
HIS A 614
ASP A 790
ILE A 793
ASN A 935
 None
 1.34A 4pooB-1f4hA:
undetectable		 4pooB-1f4hA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 HIS A 614
SER A 545
SER A 998
ASP A 572
 None
 1.17A 5a1iA-1f4hA:
undetectable		 5a1iA-1f4hA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 7 HIS A 395
PRO A 396
PHE A 209
ASP A 144
 None
 1.28A 5a1iA-1f4hA:
undetectable		 5a1iA-1f4hA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 7 ALA A  97
ASP A 598
THR A 799
GLU A 797
 None
 0.91A 5bs8A-1f4hA:
0.0
5bs8C-1f4hA:
0.0
5bs8D-1f4hA:
undetectable		 5bs8A-1f4hA:
19.17
5bs8C-1f4hA:
19.17
5bs8D-1f4hA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 7 ALA A  97
ASP A 598
THR A 799
GLU A 797
 None
 0.91A 5btgA-1f4hA:
undetectable
5btgC-1f4hA:
undetectable
5btgD-1f4hA:
undetectable		 5btgA-1f4hA:
19.17
5btgC-1f4hA:
19.17
5btgD-1f4hA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 THR A 104
THR A 101
PHE A 601
 None
 0.71A 5cxvA-1f4hA:
undetectable		 5cxvA-1f4hA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_A_C2FA402_0
(THYMIDYLATE SYNTHASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 11 ILE A 749
LEU A 835
ASP A 859
GLY A 860
ALA A 865
 None
 1.36A 5fctA-1f4hA:
0.0		 5fctA-1f4hA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 ALA A 514
ASP A 428
HIS A 468
GLY A 463
SER A 462
 None
 1.18A 5hfjB-1f4hA:
undetectable		 5hfjB-1f4hA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 ALA A 514
HIS A 468
GLY A 463
SER A 462
THR A 417
 None
 1.17A 5hfjB-1f4hA:
undetectable		 5hfjB-1f4hA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 12 ALA A 514
ASP A 428
GLY A 463
SER A 462
THR A 417
 None
 1.20A 5hfjD-1f4hA:
undetectable		 5hfjD-1f4hA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 4 ASP A 997
HIS A 391
SER A 390
GLU A 537
 None
 1.33A 5hfjG-1f4hA:
1.0		 5hfjG-1f4hA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_A_AG2A501_1
(ARGININE/AGMATINE
ANTIPORTER)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 6 SER A 933
GLY A 936
ASN A 958
ILE A 993
 None
 1.16A 5j4nA-1f4hA:
0.0		 5j4nA-1f4hA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 VAL A 114
SER A 192
TRP A 191
 None
 0.72A 5jwaA-1f4hA:
0.0		 5jwaA-1f4hA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 4 LEU A 152
ARG A  26
ILE A 141
PHE A 143
 None
 0.99A 5kirB-1f4hA:
0.0		 5kirB-1f4hA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MFX_A_ACTA701_0
(GENOME POLYPROTEIN)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 5 THR A 317
HIS A 316
ALA A 318
ASP A 319
 None
 0.94A 5mfxA-1f4hA:
0.0		 5mfxA-1f4hA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 6 TYR A 100
PHE A 601
ASP A 591
GLY A 590
 None
 1.11A 5mraA-1f4hA:
0.0
5mraB-1f4hA:
0.2		 5mraA-1f4hA:
10.79
5mraB-1f4hA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_C_SAMC501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 7 LEU A 458
GLY A 488
GLY A 463
THR A 493
ALA A 495
 None
 1.01A 5o96C-1f4hA:
2.2		 5o96C-1f4hA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 10 LEU A 458
GLY A 488
GLY A 463
THR A 493
ALA A 495
 None
 1.00A 5o96G-1f4hA:
2.1
5o96H-1f4hA:
2.8		 5o96G-1f4hA:
12.70
5o96H-1f4hA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 HIS A 840
SER A 852
LYS A 854
 None
 1.26A 5os7A-1f4hA:
undetectable		 5os7A-1f4hA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 VAL A 656
GLY A 633
LEU A 631
THR A 635
 None
 0.97A 5sxqA-1f4hA:
undetectable		 5sxqA-1f4hA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 VAL A 656
GLY A 633
LEU A 631
THR A 635
 None
 0.97A 5sxqB-1f4hA:
0.0		 5sxqB-1f4hA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 VAL A 656
GLY A 633
LEU A 631
THR A 635
 None
 0.97A 5sxtA-1f4hA:
undetectable		 5sxtA-1f4hA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 VAL A 656
GLY A 633
LEU A 631
THR A 635
 None
 0.97A 5sxtB-1f4hA:
0.0		 5sxtB-1f4hA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 VAL A 656
GLY A 633
LEU A 631
THR A 635
 None
 0.96A 5syjA-1f4hA:
undetectable		 5syjA-1f4hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 VAL A 656
GLY A 633
LEU A 631
THR A 635
 None
 0.98A 5syjB-1f4hA:
0.0		 5syjB-1f4hA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA309_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 4 LEU A 751
GLY A 862
SER A 861
SER A 734
 None
 0.94A 5uunA-1f4hA:
0.0		 5uunA-1f4hA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB306_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 4 LEU A 751
GLY A 862
SER A 861
SER A 734
 None
 0.94A 5uunB-1f4hA:
0.0		 5uunB-1f4hA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM7_A_ACTA603_0
(SALICYLATE-AMP
LIGASE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 4 THR A 493
THR A 496
ALA A 495
ARG A 531
 None
 1.30A 5wm7A-1f4hA:
3.4		 5wm7A-1f4hA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 HIS A 391
HIS A 418
TRP A 568
ARG A 204
 None
MG  A3001 (-3.6A)
None
None
 1.15A 6b94A-1f4hA:
undetectable		 6b94A-1f4hA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 ALA A 616
PHE A 549
GLN A 624
 None
 0.76A 6eceA-1f4hA:
undetectable		 6eceA-1f4hA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 HIS A 614
SER A 545
SER A 998
ASP A 572
 None
 1.14A 6fboA-1f4hA:
undetectable		 6fboA-1f4hA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 8 HIS A 614
SER A 545
SER A 998
ASP A 572
 None
 1.16A 6fcdA-1f4hA:
undetectable		 6fcdA-1f4hA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		4 / 7 HIS A 395
PRO A 396
PHE A 209
ASP A 144
 None
 1.29A 6g6rA-1f4hA:
undetectable		 6g6rA-1f4hA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		3 / 3 HIS A 840
SER A 852
LYS A 854
 None
 1.26A 6gmdB-1f4hA:
undetectable		 6gmdB-1f4hA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1f4h BETA-GALACTOSIDASE
(Escherichia
coli) 		5 / 11 SER A 971
GLY A 593
GLY A 590
ASP A 594
ASP A  96
 None
 1.28A 6i5zD-1f4hA:
undetectable		 6i5zD-1f4hA:
16.43