SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M2P_B_DHIB24_0 (INSULIN B CHAIN)	1f4w	ANTIBODY S-20-4, FAB FRAGMENT, HEAVY CHAIN (Mus musculus)	3 / 3	TYR H 179 GLY H 148 PHE H 150	None	0.72A	2m2pB-1f4wH: undetectable	2m2pB-1f4wH: 10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XN7_A_T44A1355_1 (THYROXINE-BINDING GLOBULIN)	1f4w	ANTIBODY S-20-4, FAB FRAGMENT, HEAVY CHAIN (Mus musculus)	5 / 10	LEU H 86 LEU H 113 SER H 21 LEU H 20 LEU H 18	None	1.08A	2xn7A-1f4wH: 0.8 2xn7B-1f4wH: 0.0	2xn7A-1f4wH: 21.61 2xn7B-1f4wH: 9.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M7K_H_ACTH302_0 (10H10 HEAVY CHAIN)	1f4w	ANTIBODY S-20-4, FAB FRAGMENT, HEAVY CHAIN (Mus musculus)	4 / 5	VAL H 2 TYR H 27 ARG H 98 TYR H 106	None	0.35A	4m7kH-1f4wH: 19.5	4m7kH-1f4wH: 55.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIW_D_LOCD503_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA CHAIN)	1f4w	ANTIBODY S-20-4, FAB FRAGMENT, HEAVY CHAIN (Mus musculus)	3 / 3	SER H 207 ALA H 202 VAL H 201	None	0.55A	5xiwC-1f4wH: undetectable	5xiwC-1f4wH: 17.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6CJK_B_ACTB302_0 (IMMUNOGLOBULIN FAB HEAVY CHAIN)	1f4w	ANTIBODY S-20-4, FAB FRAGMENT, HEAVY CHAIN (Mus musculus)	3 / 3	TYR H 60 GLY H 66 THR H 69	None	0.19A	6cjkB-1f4wH: 23.0	6cjkB-1f4wH: 56.62

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2M2P_B_DHIB24_0","INSULIN B CHAIN","1f4w","ANTIBODY S-20-4, FAB FRAGMENT, HEAVY CHAIN","Mus musculus",3,"TYR H 179;GLY H 148;PHE H 150","None","0.72A","2m2pB-1f4wH:undetectable","2m2pB-1f4wH:10.97"],["2XN7_A_T44A1355_1","THYROXINE-BINDING GLOBULIN;THYROXINE-BINDING GLOBULIN","1f4w","ANTIBODY S-20-4, FAB FRAGMENT, HEAVY CHAIN","Mus musculus",5,"LEU H  86;LEU H 113;SER H  21;LEU H  20;LEU H  18","None","1.08A","2xn7A-1f4wH:0.8;2xn7B-1f4wH:0.0","2xn7A-1f4wH:21.61;2xn7B-1f4wH:9.05"],["4M7K_H_ACTH302_0","10H10 HEAVY CHAIN","1f4w","ANTIBODY S-20-4, FAB FRAGMENT, HEAVY CHAIN","Mus musculus",4,"VAL H   2;TYR H  27;ARG H  98;TYR H 106","None","0.35A","4m7kH-1f4wH:19.5","4m7kH-1f4wH:55.91"],["5XIW_D_LOCD503_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA CHAIN","1f4w","ANTIBODY S-20-4, FAB FRAGMENT, HEAVY CHAIN","Mus musculus",3,"SER H 207;ALA H 202;VAL H 201","None","0.55A","5xiwC-1f4wH:undetectable","5xiwC-1f4wH:17.59"],["6CJK_B_ACTB302_0","IMMUNOGLOBULIN FAB HEAVY CHAIN","1f4w","ANTIBODY S-20-4, FAB FRAGMENT, HEAVY CHAIN","Mus musculus",3,"TYR H  60;GLY H  66;THR H  69","None","0.19A","6cjkB-1f4wH:23.0","6cjkB-1f4wH:56.62"]]