SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f51'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		4 / 8 LEU E1253
VAL E1243
LEU E1240
ALA E1233
 None
 0.92A 1fiqC-1f51E:
undetectable		 1fiqC-1f51E:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		3 / 3 ILE E1215
LEU E1218
VAL E1222
 None
 0.43A 1mz9B-1f51E:
undetectable		 1mz9B-1f51E:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RIW_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		5 / 10 LEU A 146
LEU A 148
LEU A 113
LYS A 112
LEU A 191
 None
 0.83A 2riwA-1f51A:
1.3
2riwB-1f51A:
0.0		 2riwA-1f51A:
20.94
2riwB-1f51A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN6_A_T44A1370_1
(THYROXINE-BINDING
GLOBULIN)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		5 / 10 LEU A 146
LEU A 148
LEU A 113
LYS A 112
LEU A 191
 None
 0.93A 2xn6A-1f51A:
1.3
2xn6B-1f51A:
0.0		 2xn6A-1f51A:
20.29
2xn6B-1f51A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		5 / 12 ILE E1311
LEU E1252
ILE E1308
MET E1281
PHE E1306
 None
 0.84A 2ygqA-1f51E:
undetectable		 2ygqA-1f51E:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		4 / 5 LEU E1253
ILE E1276
ILE E1280
GLY E1262
 None
 0.85A 3bufA-1f51E:
undetectable		 3bufA-1f51E:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		5 / 8 ALA E1234
ASP E1211
ASP E1210
GLY E1236
LEU E1237
 None
MG  E2001 (-3.0A)
MG  E2001 ( 4.0A)
None
None
 1.26A 3em6A-1f51E:
undetectable		 3em6A-1f51E:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		4 / 8 LEU E1253
VAL E1243
LEU E1240
ALA E1233
 None
 0.92A 3uniB-1f51E:
undetectable		 3uniB-1f51E:
6.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		5 / 12 ILE E1272
GLY E1262
VAL E1251
ILE E1276
VAL E1278
 None
 1.01A 4c9lA-1f51E:
undetectable		 4c9lA-1f51E:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		5 / 12 ILE E1272
GLY E1262
VAL E1251
ILE E1276
VAL E1278
 None
 0.98A 4c9lB-1f51E:
undetectable		 4c9lB-1f51E:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		5 / 12 ILE E1272
GLY E1262
VAL E1251
ILE E1276
VAL E1278
 None
 1.03A 4c9oA-1f51E:
undetectable		 4c9oA-1f51E:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_B_CAMB423_0
(CYTOCHROME P450)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		5 / 12 ILE E1272
GLY E1262
VAL E1251
ILE E1276
VAL E1278
 None
 1.01A 4c9oB-1f51E:
undetectable		 4c9oB-1f51E:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		4 / 4 LEU E1218
LEU A  43
GLN E1212
GLU A  57
 None
None
MG  E2001 (-4.1A)
None
 1.24A 4i41A-1f51E:
undetectable		 4i41A-1f51E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		5 / 11 ALA A 111
LEU A 110
LEU A 137
LEU A  71
LEU A 103
 None
 0.96A 4wg0C-1f51A:
undetectable
4wg0D-1f51A:
undetectable
4wg0E-1f51A:
undetectable		 4wg0C-1f51A:
5.45
4wg0D-1f51A:
5.45
4wg0E-1f51A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		5 / 11 LEU A 137
LEU A 110
LEU A 191
ARG A 144
LEU A 146
 None
 0.99A 4wg0C-1f51A:
undetectable
4wg0D-1f51A:
undetectable
4wg0E-1f51A:
undetectable		 4wg0C-1f51A:
5.45
4wg0D-1f51A:
5.45
4wg0E-1f51A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		5 / 11 LEU A  71
LEU A 103
LEU A 137
ALA A 111
LEU A 110
 None
 0.98A 4wg0F-1f51A:
undetectable
4wg0G-1f51A:
undetectable
4wg0H-1f51A:
undetectable		 4wg0F-1f51A:
5.45
4wg0G-1f51A:
5.45
4wg0H-1f51A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		5 / 11 ALA A 111
LEU A 110
LEU A 137
LEU A  71
LEU A 103
 None
 0.96A 4wg0E-1f51A:
undetectable
4wg0F-1f51A:
undetectable
4wg0G-1f51A:
undetectable		 4wg0E-1f51A:
5.45
4wg0F-1f51A:
5.45
4wg0G-1f51A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		5 / 11 LEU A 137
LEU A 110
LEU A 191
ARG A 144
LEU A 146
 None
 0.97A 4wg0E-1f51A:
undetectable
4wg0F-1f51A:
undetectable
4wg0G-1f51A:
undetectable		 4wg0E-1f51A:
5.45
4wg0F-1f51A:
5.45
4wg0G-1f51A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_H_CHDH103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		5 / 11 LEU A  71
LEU A 103
LEU A 137
ALA A 111
LEU A 110
 None
 0.99A 4wg0H-1f51A:
undetectable
4wg0I-1f51A:
undetectable
4wg0J-1f51A:
undetectable		 4wg0H-1f51A:
5.45
4wg0I-1f51A:
5.45
4wg0J-1f51A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		5 / 11 ALA A 111
LEU A 110
LEU A 137
LEU A  71
LEU A 103
 None
 0.97A 4wg0G-1f51A:
undetectable
4wg0H-1f51A:
undetectable
4wg0I-1f51A:
undetectable		 4wg0G-1f51A:
5.45
4wg0H-1f51A:
5.45
4wg0I-1f51A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		5 / 11 ALA A 111
LEU A 110
LEU A 137
LEU A  71
LEU A 103
 None
 0.98A 4wg0I-1f51A:
undetectable
4wg0J-1f51A:
undetectable
4wg0K-1f51A:
undetectable		 4wg0I-1f51A:
5.45
4wg0J-1f51A:
5.45
4wg0K-1f51A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		5 / 11 ALA A 111
LEU A 110
LEU A 137
LEU A  71
LEU A 103
 None
 0.99A 4wg0K-1f51A:
undetectable
4wg0L-1f51A:
undetectable
4wg0M-1f51A:
undetectable		 4wg0K-1f51A:
5.45
4wg0L-1f51A:
5.45
4wg0M-1f51A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		4 / 6 ASP A  31
ASN A  42
ASN A  34
GLN A  37
 None
None
MG  E2001 ( 4.6A)
None
 1.26A 5l6eA-1f51A:
undetectable		 5l6eA-1f51A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE B
(Bacillus
subtilis) 		3 / 3 TRP A  32
MET A  33
ASN A  34
 None
None
MG  E2001 ( 4.6A)
 1.18A 5uc1A-1f51A:
0.0		 5uc1A-1f51A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		5 / 9 VAL E1243
VAL E1278
LEU E1240
GLY E1262
VAL E1209
 None
 1.24A 6czmA-1f51E:
0.0
6czmB-1f51E:
1.5		 6czmA-1f51E:
16.43
6czmB-1f51E:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		5 / 9 VAL E1243
VAL E1278
LEU E1240
GLY E1262
VAL E1209
 None
 1.22A 6czmB-1f51E:
1.5
6czmC-1f51E:
0.3		 6czmB-1f51E:
16.43
6czmC-1f51E:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		5 / 9 VAL E1243
VAL E1278
LEU E1240
GLY E1262
VAL E1209
 None
 1.25A 6czmD-1f51E:
1.8
6czmE-1f51E:
0.0		 6czmD-1f51E:
16.43
6czmE-1f51E:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F
(Bacillus
subtilis) 		5 / 10 VAL E1243
VAL E1278
LEU E1240
GLY E1262
VAL E1209
 None
 1.24A 6czmE-1f51E:
0.0
6czmF-1f51E:
0.0		 6czmE-1f51E:
16.43
6czmF-1f51E:
16.43