SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f59'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 GLY A 391
LEU A 394
THR A 427
ALA A 428
LEU A 416
 None
 1.17A 1jg2A-1f59A:
undetectable		 1jg2A-1f59A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA733_1
(ALPHA AMYLASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		4 / 6 SER A  67
THR A  66
ASN A  63
LEU A  59
 None
 1.09A 1mxdA-1f59A:
undetectable		 1mxdA-1f59A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA443_1
(ALPHA AMYLASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		4 / 8 SER A  67
THR A  66
ASN A  63
LEU A  59
 None
 1.04A 1mxgA-1f59A:
undetectable		 1mxgA-1f59A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		3 / 3 THR A 150
LEU A 151
LEU A 198
 None
 0.62A 1mz9C-1f59A:
undetectable		 1mz9C-1f59A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		4 / 5 ASP A 230
LEU A 192
LYS A 191
ARG A 232
 None
 1.21A 2gj5A-1f59A:
undetectable		 2gj5A-1f59A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		3 / 3 ARG A 182
GLY A 180
SER A 201
 None
 0.60A 2xctB-1f59A:
undetectable		 2xctB-1f59A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		3 / 3 GLU A 214
ASP A 210
TYR A 248
 None
 0.78A 2yvlB-1f59A:
undetectable		 2yvlB-1f59A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 VAL A 364
GLN A 408
ALA A 409
THR A 412
ILE A 375
 None
 1.11A 3a35A-1f59A:
undetectable		 3a35A-1f59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 VAL A 364
GLN A 408
ALA A 409
THR A 412
ILE A 375
 None
 1.15A 3a35B-1f59A:
undetectable		 3a35B-1f59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 VAL A 364
GLN A 408
ALA A 409
THR A 412
ILE A 375
 None
 1.16A 3a3bA-1f59A:
undetectable		 3a3bA-1f59A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 VAL A 364
GLN A 408
ALA A 409
THR A 412
ILE A 375
 None
 1.17A 3ddyA-1f59A:
undetectable		 3ddyA-1f59A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		3 / 3 ASN A  63
ASP A 160
GLN A 159
 None
 0.72A 3eeyC-1f59A:
undetectable		 3eeyC-1f59A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		3 / 3 ASN A  63
ASP A 160
GLN A 159
 None
 0.72A 3eeyD-1f59A:
undetectable		 3eeyD-1f59A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		3 / 3 ASN A  63
ASP A 160
GLN A 159
 None
 0.72A 3eeyE-1f59A:
undetectable		 3eeyE-1f59A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		4 / 6 ILE A 371
ALA A 386
ALA A 428
THR A 431
 None
 0.91A 3mdrB-1f59A:
0.0		 3mdrB-1f59A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_B_FLPB701_1
(CYCLOOXYGENASE-2)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 11 VAL A  43
LEU A  44
LEU A   3
TYR A 104
ALA A  56
 None
 1.24A 3pghB-1f59A:
0.0		 3pghB-1f59A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA452_1
(CYTOCHROME P450
164A2)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 ALA A 176
ALA A 194
THR A 195
LEU A 198
LEU A 241
 None
 1.05A 3r9cA-1f59A:
1.4		 3r9cA-1f59A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		4 / 4 LYS A 191
ASN A 188
VAL A 233
ASP A 230
 None
 1.36A 4fglD-1f59A:
0.0		 4fglD-1f59A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_C_NOVC2000_1
(DNA GYRASE SUBUNIT B)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 ASP A 168
ILE A 121
PRO A 122
GLN A  77
ILE A 161
 None
 1.30A 4uroC-1f59A:
undetectable		 4uroC-1f59A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		3 / 3 VAL A 424
LEU A 416
VAL A 387
 None
 0.53A 4wq4A-1f59A:
0.0		 4wq4A-1f59A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		6 / 9 LEU A  99
ALA A 153
LEU A 133
LEU A 129
ALA A 117
ALA A 109
 None
 1.26A 4z91F-1f59A:
1.7
4z91G-1f59A:
1.4
4z91H-1f59A:
1.7
4z91I-1f59A:
1.6
4z91J-1f59A:
1.5		 4z91F-1f59A:
20.43
4z91G-1f59A:
20.43
4z91H-1f59A:
20.43
4z91I-1f59A:
20.43
4z91J-1f59A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		3 / 3 ALA A 237
ASN A 240
LEU A 241
 None
 0.51A 5i1nC-1f59A:
undetectable		 5i1nC-1f59A:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 VAL A  43
LEU A  44
LEU A   3
TYR A 104
ALA A  56
 None
 1.11A 5ikrB-1f59A:
0.0		 5ikrB-1f59A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LBT_B_6T0B304_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		4 / 4 LYS A 191
ASN A 188
VAL A 233
ASP A 230
 None
 1.37A 5lbtB-1f59A:
0.0		 5lbtB-1f59A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 ILE A 157
VAL A 134
VAL A 137
ILE A 116
ALA A 117
 None
 0.92A 5n0sA-1f59A:
0.0		 5n0sA-1f59A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 ILE A 157
VAL A 134
VAL A 137
ILE A 116
ALA A 117
 None
 0.92A 5n0sB-1f59A:
0.0		 5n0sB-1f59A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 ILE A 157
VAL A 134
VAL A 137
ILE A 116
ALA A 117
 None
 0.87A 5n0tA-1f59A:
undetectable		 5n0tA-1f59A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 ILE A 157
VAL A 134
VAL A 137
ILE A 116
ALA A 117
 None
 0.89A 5n0wB-1f59A:
undetectable		 5n0wB-1f59A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		5 / 12 ILE A 157
VAL A 134
VAL A 137
ILE A 116
ALA A 117
 None
 0.89A 5n4iA-1f59A:
0.1		 5n4iA-1f59A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		4 / 8 ILE A 363
ALA A 389
LEU A 326
THR A 327
 None
 0.79A 5og9A-1f59A:
0.0		 5og9A-1f59A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1f59 IMPORTIN BETA-1
(Homo
sapiens) 		3 / 3 LEU A  65
ASN A  93
LEU A  44
 None
 0.70A 6exiA-1f59A:
undetectable		 6exiA-1f59A:
12.95