SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_2
(ESTROGEN RECEPTOR)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		4 / 6 LEU A 105
HIS A 212
LEU A 190
LEU A 193
 None
 0.89A 1errA-1f5aA:
0.0		 1errA-1f5aA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		4 / 4 ALA A 381
ARG A 387
GLN A 386
GLU A 384
 None
 1.31A 1lqtB-1f5aA:
undetectable		 1lqtB-1f5aA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		4 / 4 ALA A 381
ARG A 387
GLN A 386
GLU A 384
 None
 1.33A 1lquB-1f5aA:
undetectable		 1lquB-1f5aA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		4 / 7 TRP A 230
GLU A 340
ILE A 236
LEU A 361
 None
 1.48A 1q0yH-1f5aA:
undetectable
1q0yL-1f5aA:
undetectable		 1q0yH-1f5aA:
19.09
1q0yL-1f5aA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		5 / 11 LEU A 193
ARG A 126
VAL A 124
ALA A 120
LEU A 117
 None
 1.21A 2q72A-1f5aA:
0.0		 2q72A-1f5aA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		3 / 3 ARG A 196
ARG A 199
PRO A 155
 None
 1.08A 2wljA-1f5aA:
0.0		 2wljA-1f5aA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_B_PAUB248_0
(TYPE III
PANTOTHENATE KINASE)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		5 / 12 LEU A 252
VAL A 247
GLY A 246
THR A 326
ILE A 315
 None
3AT  A1000 (-3.9A)
3AT  A1000 (-3.0A)
None
None
 1.13A 3bf1A-1f5aA:
undetectable
3bf1B-1f5aA:
undetectable		 3bf1A-1f5aA:
18.43
3bf1B-1f5aA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		5 / 12 VAL A 247
LEU A 252
ILE A 316
VAL A 285
LEU A 286
 3AT  A1000 (-3.9A)
None
None
None
None
 1.25A 3w68C-1f5aA:
0.0		 3w68C-1f5aA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		5 / 12 LEU A  68
VAL A  72
ALA A 120
PHE A 129
PHE A 170
 None
 1.20A 4ib4A-1f5aA:
undetectable		 4ib4A-1f5aA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		3 / 3 SER A 248
MET A 251
ASP A 115
 None
None
MN  A1002 (-2.6A)
 0.75A 4mm4B-1f5aA:
0.0		 4mm4B-1f5aA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		3 / 3 SER A 307
ASP A 308
GLN A 323
 None
 0.88A 4oltA-1f5aA:
0.0
4oltB-1f5aA:
0.0		 4oltA-1f5aA:
18.42
4oltB-1f5aA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		3 / 3 GLN A 323
SER A 307
ASP A 308
 None
 0.87A 4qwpA-1f5aA:
0.0
4qwpB-1f5aA:
0.0		 4qwpA-1f5aA:
18.42
4qwpB-1f5aA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		3 / 3 ARG A  61
GLU A  55
TYR A 103
 None
 0.95A 4r29D-1f5aA:
0.0		 4r29D-1f5aA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		4 / 6 LEU A  71
GLU A  78
ILE A 157
PRO A 121
 None
 1.00A 4xi3C-1f5aA:
undetectable		 4xi3C-1f5aA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_A_ASDA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		4 / 7 VAL A  72
ILE A  76
LEU A 189
LEU A 173
 None
 1.01A 4xo7A-1f5aA:
undetectable		 4xo7A-1f5aA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		4 / 5 LEU A 173
ALA A 120
LEU A 175
VAL A  72
 None
 1.01A 5cr1A-1f5aA:
0.2		 5cr1A-1f5aA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		5 / 12 VAL A 275
PHE A 273
ILE A 227
LEU A 105
LEU A 252
 None
 1.11A 5fctB-1f5aA:
0.0		 5fctB-1f5aA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		4 / 5 MET A 313
TYR A 237
GLY A 245
GLY A 246
 None
3AT  A1000 (-4.7A)
None
3AT  A1000 (-3.0A)
 0.84A 5x7pA-1f5aA:
undetectable		 5x7pA-1f5aA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1f5a POLY(A) POLYMERASE
(Bos
taurus) 		4 / 6 MET A 313
TYR A 237
GLY A 245
GLY A 246
 None
3AT  A1000 (-4.7A)
None
3AT  A1000 (-3.0A)
 0.85A 5x7pB-1f5aA:
undetectable		 5x7pB-1f5aA:
16.77