SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f5j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		4 / 8 ARG A  47
TYR A  52
GLY A  49
ILE A  64
 None
 0.89A 2f9wA-1f5jA:
undetectable
2f9wB-1f5jA:
undetectable		 2f9wA-1f5jA:
19.85
2f9wB-1f5jA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		4 / 7 TYR A  52
ILE A 175
THR A 171
THR A  85
 None
 1.03A 3tneB-1f5jA:
undetectable		 3tneB-1f5jA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_1
(PROTEASE)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		5 / 12 GLY A  82
ILE A  62
GLY A  49
VAL A 153
VAL A 155
 None
 0.75A 3ucbA-1f5jA:
undetectable		 3ucbA-1f5jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UCB_A_017A201_2
(PROTEASE)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		5 / 12 GLY A  82
ILE A  62
GLY A  49
VAL A 153
VAL A 155
 None
 0.71A 3ucbB-1f5jA:
undetectable		 3ucbB-1f5jA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		3 / 3 LYS A  19
LEU A  17
ALA A  44
 None
 0.56A 4iizA-1f5jA:
0.4		 4iizA-1f5jA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		4 / 7 LYS A  19
LEU A  17
ALA A  44
SER A  76
 None
 0.85A 4ikjA-1f5jA:
0.0
4ikjB-1f5jA:
undetectable		 4ikjA-1f5jA:
19.39
4ikjB-1f5jA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_A_SUZA201_1
(TRANSTHYRETIN)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		4 / 8 LYS A  19
LEU A  17
ALA A  44
SER A  76
 None
 0.71A 4ikkA-1f5jA:
0.0
4ikkB-1f5jA:
undetectable		 4ikkA-1f5jA:
19.39
4ikkB-1f5jA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		4 / 7 LYS A  19
LEU A  17
ALA A  44
SER A  76
 None
 0.60A 4iklA-1f5jA:
undetectable
4iklB-1f5jA:
undetectable		 4iklA-1f5jA:
19.39
4iklB-1f5jA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		4 / 8 GLY A  49
TYR A  14
TRP A  83
ARG A  47
 None
 1.19A 4m5mA-1f5jA:
undetectable		 4m5mA-1f5jA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		4 / 8 GLU A  16
ILE A 131
GLN A 174
ILE A 175
 None
 0.88A 4mj8A-1f5jA:
undetectable		 4mj8A-1f5jA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		4 / 6 GLY A  49
THR A  48
TYR A  13
ASN A 193
 None
 0.92A 5k4pA-1f5jA:
undetectable		 5k4pA-1f5jA:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		5 / 8 TYR A 121
THR A 123
ARG A 125
GLN A 139
TRP A 141
 None
 0.94A 5tzoA-1f5jA:
25.4		 5tzoA-1f5jA:
42.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_A_7V7A202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		5 / 12 TRP A  83
TYR A  92
PRO A 129
TRP A 141
GLY A 181
 None
 0.71A 5tzoA-1f5jA:
25.4		 5tzoA-1f5jA:
42.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B201_2
(ENDO-1,4-BETA-XYLANA
SE A)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		3 / 3 ARG A 125
PRO A 129
TYR A 182
 None
 0.78A 5tzoB-1f5jA:
25.6		 5tzoB-1f5jA:
42.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		4 / 8 TRP A 100
THR A 123
ARG A 125
GLN A 139
 None
 1.10A 5tzoB-1f5jA:
25.6		 5tzoB-1f5jA:
42.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		5 / 8 TYR A 121
THR A 123
ARG A 125
GLN A 139
TRP A 141
 None
 0.75A 5tzoB-1f5jA:
25.6		 5tzoB-1f5jA:
42.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		5 / 12 TRP A  83
TYR A  92
PRO A 129
TRP A 141
GLY A 181
 None
 0.74A 5tzoC-1f5jA:
25.2		 5tzoC-1f5jA:
42.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		4 / 8 TRP A 100
THR A 123
ARG A 125
GLN A 139
 None
 1.27A 5tzoC-1f5jA:
25.2		 5tzoC-1f5jA:
42.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5TZO_C_7V7C202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 1f5j BETA-1,4-XYLANASE
(Dictyoglomus
thermophilum) 		5 / 8 TYR A 121
THR A 123
ARG A 125
GLN A 139
TRP A 141
 None
 0.86A 5tzoC-1f5jA:
25.2		 5tzoC-1f5jA:
42.56