SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1f5m GAF
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 154
TYR A 155
ASP A 115
ASN A 117
 None
 0.98A 1rjdA-1f5mA:
undetectable		 1rjdA-1f5mA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1f5m GAF
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 154
TYR A 155
ASP A 115
ASN A 117
 None
 0.96A 1rjdB-1f5mA:
undetectable		 1rjdB-1f5mA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1f5m GAF
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 154
TYR A 155
ASP A 115
ASN A 117
 None
 0.94A 1rjdC-1f5mA:
undetectable		 1rjdC-1f5mA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 1f5m GAF
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  28
SER A  31
TYR A  32
LEU A 169
 None
 1.29A 1xz1A-1f5mA:
0.3		 1xz1A-1f5mA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 1f5m GAF
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  28
SER A  31
TYR A  32
LEU A 169
 None
 1.29A 1xz3A-1f5mA:
0.3		 1xz3A-1f5mA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_A_BEZA11_0
(CES1 PROTEIN)		 1f5m GAF
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  52
SER A  36
LEU A  29
LEU A 169
 None
 1.17A 1yajA-1f5mA:
undetectable		 1yajA-1f5mA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1f5m GAF
(Saccharomyces
cerevisiae) 		4 / 8 ILE A  64
ALA A  56
LEU A  25
ILE A 150
 None
 0.81A 2w9sE-1f5mA:
undetectable		 2w9sE-1f5mA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_F_TOPF1159_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 1f5m GAF
(Saccharomyces
cerevisiae) 		5 / 10 ILE A  64
ALA A  56
LEU A  25
LEU A 166
ILE A 150
 None
 1.20A 2w9sF-1f5mA:
undetectable		 2w9sF-1f5mA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 1f5m GAF
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  62
TYR A  57
ILE A 133
ASP A 159
 None
 1.04A 2x45B-1f5mA:
0.6		 2x45B-1f5mA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 1f5m GAF
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  62
TYR A  57
ILE A 133
ASP A 159
 None
 1.06A 2x45C-1f5mA:
0.0		 2x45C-1f5mA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 1f5m GAF
(Saccharomyces
cerevisiae) 		4 / 7 VAL A  62
TYR A  57
ILE A 133
ASP A 159
 None
 1.20A 3bu1A-1f5mA:
0.0		 3bu1A-1f5mA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F33_A_PFLA2001_1
(FERRITIN LIGHT CHAIN)		 1f5m GAF
(Saccharomyces
cerevisiae) 		5 / 6 LEU A  28
SER A  31
TYR A  32
LEU A  35
LEU A 169
 None
 1.40A 3f33A-1f5mA:
undetectable		 3f33A-1f5mA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_0
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 1f5m GAF
(Saccharomyces
cerevisiae) 		5 / 12 ASN A  65
VAL A 100
ILE A  53
THR A 110
PHE A 158
 None
 1.46A 6j20A-1f5mA:
0.8		 6j20A-1f5mA:
15.44