SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 148
ILE A  78
TYR A 300
VAL A  44
 None
 1.04A 1db1A-1f5nA:
0.7		 1db1A-1f5nA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLY A  68
GLY A 100
TYR A  47
SER A  66
 GNP  A 593 (-3.8A)
GNP  A 593 (-3.1A)
None
None
 0.99A 1eswA-1f5nA:
undetectable		 1eswA-1f5nA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 THR A 532
GLU A 526
ASP A 359
 None
 0.70A 1nt2A-1f5nA:
0.0		 1nt2A-1f5nA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 126
VAL A  44
LEU A 101
PHE A 178
 None
 1.03A 1wrlB-1f5nA:
undetectable		 1wrlB-1f5nA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 126
VAL A  44
LEU A 101
PHE A 230
 None
 1.04A 1wrlB-1f5nA:
undetectable		 1wrlB-1f5nA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 ASN A 302
LEU A 118
LEU A 296
ILE A  14
 None
 1.01A 1z95A-1f5nA:
0.0		 1z95A-1f5nA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 PHE A 116
PHE A 126
PHE A 178
 None
 0.83A 2od9A-1f5nA:
0.8		 2od9A-1f5nA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 PHE A 116
PHE A 126
PHE A 178
 None
 0.83A 2qqgA-1f5nA:
0.8		 2qqgA-1f5nA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A  67
GLU A 251
SER A  52
PHE A  65
 GNP  A 593 (-3.9A)
None
MG  A 595 ( 2.2A)
None
 1.31A 3i9jB-1f5nA:
undetectable		 3i9jB-1f5nA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_1
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 ARG A 292
ASP A 538
GLN A 381
 None
 0.94A 3lcvB-1f5nA:
undetectable		 3lcvB-1f5nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 TYR A  47
GLY A 102
ASP A 112
 None
 0.71A 3ou6C-1f5nA:
undetectable		 3ou6C-1f5nA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE A 230
PHE A 116
ALA A 119
THR A  98
ILE A  43
 None
 1.30A 3t3qA-1f5nA:
undetectable		 3t3qA-1f5nA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE A 230
PHE A 116
ALA A 119
THR A  98
ILE A  43
 None
 1.31A 3t3qB-1f5nA:
0.0		 3t3qB-1f5nA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 10 PHE A 230
PHE A 116
ALA A 119
THR A  98
ILE A  43
 None
 1.30A 3t3qC-1f5nA:
undetectable		 3t3qC-1f5nA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 6 PHE A 230
PHE A 116
ALA A 119
THR A  98
 None
 1.18A 3t3sB-1f5nA:
0.1		 3t3sB-1f5nA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 TYR A 128
VAL A 145
LEU A 202
LEU A 206
 None
 0.90A 4jtrA-1f5nA:
undetectable		 4jtrA-1f5nA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 PHE A 178
THR A 146
PHE A 116
ILE A 226
 None
 1.26A 4jx1E-1f5nA:
0.0		 4jx1E-1f5nA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 5 TYR A 128
THR A 146
PHE A 116
ILE A 226
 None
 1.04A 4jx1E-1f5nA:
0.0		 4jx1E-1f5nA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		3 / 3 SER A  52
MET A  55
ASP A 184
 MG  A 595 ( 2.2A)
None
GNP  A 593 (-2.9A)
 0.90A 4mm4B-1f5nA:
0.0		 4mm4B-1f5nA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 6 LEU A 118
ILE A 304
ALA A 303
THR A 299
ALA A 315
 None
 1.01A 4zf8A-1f5nA:
0.0		 4zf8A-1f5nA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		5 / 9 PRO A 291
VAL A 316
LEU A 282
ILE A 286
LEU A  13
 None
 1.40A 5iepA-1f5nA:
0.0		 5iepA-1f5nA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 104
GLY A  45
GLN A 141
LEU A  46
 None
 1.01A 5sxqA-1f5nA:
0.0		 5sxqA-1f5nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 104
GLY A  45
GLN A 141
LEU A  46
 None
 1.00A 5sxqB-1f5nA:
0.0		 5sxqB-1f5nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_A_NIZA807_1
(CATALASE-PEROXIDASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 104
GLY A  45
GLN A 141
LEU A  46
 None
 0.97A 5sxtA-1f5nA:
0.0		 5sxtA-1f5nA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXT_B_NIZB808_1
(CATALASE-PEROXIDASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 104
GLY A  45
GLN A 141
LEU A  46
 None
 0.97A 5sxtB-1f5nA:
0.0		 5sxtB-1f5nA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA809_1
(CATALASE-PEROXIDASE)		 1f5n INTERFERON-INDUCED
GUANYLATE-BINDING
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 104
GLY A  45
GLN A 141
LEU A  46
 None
 0.99A 5syjA-1f5nA:
3.2		 5syjA-1f5nA:
22.18