SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f5v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE
(Escherichia
coli) 		5 / 12 HIS A  69
ILE A  14
LEU A 157
PHE A  17
ALA A 118
 None
 1.07A 1axwA-1f5vA:
0.0		 1axwA-1f5vA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_B_C2FB266_0
(THYMIDYLATE SYNTHASE)		 1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE
(Escherichia
coli) 		5 / 12 HIS A  69
ILE A  14
LEU A 157
PHE A  17
ALA A 118
 None
 0.99A 1tlsB-1f5vA:
0.0		 1tlsB-1f5vA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE
(Escherichia
coli) 		4 / 8 LEU A 116
LEU A   7
ILE A   8
HIS A  11
 None
None
None
FMN  A 360 (-3.9A)
 0.90A 2azxA-1f5vA:
undetectable		 2azxA-1f5vA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE
(Escherichia
coli) 		3 / 3 GLY A 104
ASP A 107
SER A  46
 None
 0.71A 2qhfA-1f5vA:
0.0		 2qhfA-1f5vA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE
(Escherichia
coli) 		5 / 12 LEU A 143
ALA A  81
THR A  64
VAL A  70
ILE A  51
 None
 1.11A 3czhB-1f5vA:
0.0		 3czhB-1f5vA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE
(Escherichia
coli) 		4 / 5 ASN A 206
ASP A 210
THR A 219
SER A 205
 None
 1.12A 3p2kC-1f5vA:
undetectable		 3p2kC-1f5vA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE
(Escherichia
coli) 		5 / 12 HIS A  69
ILE A  14
LEU A 157
PHE A  17
ALA A 118
 None
 1.13A 4fqsA-1f5vA:
0.0		 4fqsA-1f5vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE
(Escherichia
coli) 		5 / 12 HIS A  69
ILE A  14
LEU A 157
PHE A  17
ALA A 118
 None
 1.13A 4fqsB-1f5vA:
0.0		 4fqsB-1f5vA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE
(Escherichia
coli) 		3 / 3 GLU A 198
TYR A 199
ARG A 203
 None
 0.71A 5uunA-1f5vA:
0.0		 5uunA-1f5vA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1f5v OXYGEN-INSENSITIVE
NADPH NITROREDUCTASE
(Escherichia
coli) 		3 / 3 GLU A 198
TYR A 199
ARG A 203
 None
 0.59A 5uunB-1f5vA:
0.0		 5uunB-1f5vA:
20.40