SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f6f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 1f6f PLACENTAL LACTOGEN
(Ovis
aries) 		5 / 10 LEU A 172
HIS A  98
LEU A  97
ALA A 100
LEU A 157
 None
 1.09A 4p65A-1f6fA:
undetectable
4p65B-1f6fA:
undetectable
4p65F-1f6fA:
undetectable
4p65H-1f6fA:
undetectable		 4p65A-1f6fA:
10.42
4p65B-1f6fA:
12.36
4p65F-1f6fA:
12.36
4p65H-1f6fA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 1f6f PLACENTAL LACTOGEN
(Ovis
aries) 		5 / 11 LEU A 172
HIS A  98
LEU A  97
ALA A 100
LEU A 157
 None
 1.03A 4p65C-1f6fA:
undetectable
4p65D-1f6fA:
undetectable
4p65J-1f6fA:
undetectable
4p65L-1f6fA:
undetectable		 4p65C-1f6fA:
10.42
4p65D-1f6fA:
12.36
4p65J-1f6fA:
12.36
4p65L-1f6fA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 1f6f PLACENTAL LACTOGEN
(Ovis
aries) 		5 / 11 LEU A 172
HIS A  98
LEU A  97
ALA A 100
LEU A 157
 None
 0.84A 4p65E-1f6fA:
undetectable
4p65F-1f6fA:
undetectable
4p65J-1f6fA:
undetectable
4p65L-1f6fA:
undetectable		 4p65E-1f6fA:
10.42
4p65F-1f6fA:
12.36
4p65J-1f6fA:
12.36
4p65L-1f6fA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 1f6f PLACENTAL LACTOGEN
(Ovis
aries) 		5 / 11 LEU A 157
LEU A 172
HIS A  98
LEU A  97
ALA A 100
 None
 1.05A 4p65B-1f6fA:
undetectable
4p65D-1f6fA:
undetectable
4p65G-1f6fA:
undetectable
4p65H-1f6fA:
undetectable		 4p65B-1f6fA:
12.36
4p65D-1f6fA:
12.36
4p65G-1f6fA:
10.42
4p65H-1f6fA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1f6f PROLACTIN RECEPTOR
(Rattus
norvegicus) 		3 / 3 TYR B 144
THR B 182
THR B 161
 None
 0.80A 5aoxE-1f6fB:
0.7		 5aoxE-1f6fB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 1f6f PROLACTIN RECEPTOR
(Rattus
norvegicus) 		3 / 3 TYR B  75
LYS B  73
LYS B  42
 None
 1.23A 5dbyA-1f6fB:
undetectable		 5dbyA-1f6fB:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 1f6f PROLACTIN RECEPTOR
(Rattus
norvegicus) 		4 / 8 SER B 198
THR B 110
THR B 182
SER B 195
 None
 0.97A 5l4eA-1f6fB:
undetectable
5l4eB-1f6fB:
2.5
5l4eC-1f6fB:
undetectable
5l4eD-1f6fB:
0.0
5l4eE-1f6fB:
undetectable		 5l4eA-1f6fB:
22.36
5l4eB-1f6fB:
22.36
5l4eC-1f6fB:
22.36
5l4eD-1f6fB:
22.36
5l4eE-1f6fB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 1f6f PROLACTIN RECEPTOR
(Rattus
norvegicus) 		4 / 8 THR B 182
SER B 195
SER B 198
THR B 110
 None
 0.98A 5l4eA-1f6fB:
undetectable
5l4eB-1f6fB:
2.5
5l4eC-1f6fB:
undetectable
5l4eD-1f6fB:
0.0
5l4eE-1f6fB:
undetectable		 5l4eA-1f6fB:
22.36
5l4eB-1f6fB:
22.36
5l4eC-1f6fB:
22.36
5l4eD-1f6fB:
22.36
5l4eE-1f6fB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 1f6f PLACENTAL LACTOGEN
(Ovis
aries) 		4 / 7 ILE A 121
LEU A 172
THR A 102
THR A  62
 None
 0.94A 5vc0A-1f6fA:
undetectable		 5vc0A-1f6fA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 1f6f PLACENTAL LACTOGEN
(Ovis
aries) 		5 / 12 LEU A  18
PHE A  22
PHE A  83
ASP A  79
ILE A  75
 None
 1.31A 6dwnA-1f6fA:
undetectable		 6dwnA-1f6fA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 1f6f PLACENTAL LACTOGEN
(Ovis
aries) 		5 / 12 LEU A  18
PHE A  22
PHE A  83
ASP A  79
ILE A  75
 None
 1.32A 6dwnB-1f6fA:
undetectable		 6dwnB-1f6fA:
17.53