SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f75'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 1f75 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Micrococcus
luteus) 		5 / 12 GLY A 149
GLY A 150
ASN A 206
ALA A 157
LEU A 184
 None
 0.93A 1bx4A-1f75A:
undetectable		 1bx4A-1f75A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 1f75 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Micrococcus
luteus) 		5 / 12 PHE A 207
LEU A 146
ALA A 145
PRO A 192
VAL A 143
 None
 1.14A 3cwkA-1f75A:
0.0		 3cwkA-1f75A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1f75 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Micrococcus
luteus) 		4 / 8 LEU A 208
VAL A 143
TYR A  71
LEU A 195
 None
 1.13A 4q0bA-1f75A:
undetectable		 4q0bA-1f75A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 1f75 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Micrococcus
luteus) 		5 / 9 PHE A 144
THR A  57
VAL A 108
VAL A 110
LEU A 140
 None
 1.05A 4wnvA-1f75A:
0.0		 4wnvA-1f75A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1f75 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Micrococcus
luteus) 		4 / 7 ILE A 113
GLY A 114
LEU A 100
PHE A  95
 None
 0.77A 5hieB-1f75A:
undetectable		 5hieB-1f75A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1f75 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE
(Micrococcus
luteus) 		5 / 12 ILE A 220
ILE A  20
ILE A  56
VAL A  65
ILE A  24
 None
 0.83A 5mueA-1f75A:
2.6		 5mueA-1f75A:
24.15