SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f76'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 11 ALA A  61
ILE A 298
GLY A 320
ILE A 322
THR A 247
 FMN  A1337 (-3.4A)
None
None
None
ORO  A1338 ( 2.6A)
 0.88A 1c6yA-1f76A:
undetectable		 1c6yA-1f76A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 SER A 223
GLU A 224
GLU A 225
 None
 0.54A 1eqbD-1f76A:
1.3		 1eqbD-1f76A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 SER A 223
GLU A 224
GLU A 225
 None
 0.54A 1eqbB-1f76A:
1.3		 1eqbB-1f76A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 6 ASN A 111
ASN A 172
ASN A 246
THR A 247
 ORO  A1338 ( 2.9A)
ORO  A1338 ( 3.2A)
ORO  A1338 (-3.0A)
ORO  A1338 ( 2.6A)
 0.16A 1h7xA-1f76A:
29.5		 1h7xA-1f76A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 6 ASN A 111
ASN A 172
ASN A 246
THR A 247
 ORO  A1338 ( 2.9A)
ORO  A1338 ( 3.2A)
ORO  A1338 (-3.0A)
ORO  A1338 ( 2.6A)
 0.13A 1h7xB-1f76A:
29.5		 1h7xB-1f76A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 6 ASN A 111
ASN A 172
ASN A 246
THR A 247
 ORO  A1338 ( 2.9A)
ORO  A1338 ( 3.2A)
ORO  A1338 (-3.0A)
ORO  A1338 ( 2.6A)
 0.17A 1h7xC-1f76A:
29.5		 1h7xC-1f76A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 6 ASN A 111
ASN A 172
ASN A 246
THR A 247
 ORO  A1338 ( 2.9A)
ORO  A1338 ( 3.2A)
ORO  A1338 (-3.0A)
ORO  A1338 ( 2.6A)
 0.16A 1h7xD-1f76A:
29.5		 1h7xD-1f76A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 8 LEU A 227
GLU A 224
GLU A 226
ILE A 278
 None
 1.07A 1qvtA-1f76A:
0.6		 1qvtA-1f76A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 10 ALA A  61
ILE A 298
GLY A 320
ILE A 322
THR A 247
 FMN  A1337 (-3.4A)
None
None
None
ORO  A1338 ( 2.6A)
 0.92A 1t7iA-1f76A:
undetectable		 1t7iA-1f76A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 9 LEU A 190
LEU A 194
ILE A 197
ILE A 173
TYR A 155
 None
 1.19A 2f78A-1f76A:
undetectable		 2f78A-1f76A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 9 LEU A 190
LEU A 194
ILE A 197
ILE A 173
TYR A 155
 None
 1.18A 2f7aA-1f76A:
undetectable		 2f7aA-1f76A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 6 GLY A 241
GLY A 294
GLN A 316
PHE A  54
 None
 1.02A 2qx6A-1f76A:
undetectable
2qx6B-1f76A:
undetectable		 2qx6A-1f76A:
21.47
2qx6B-1f76A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 9 ALA A  61
ILE A 298
GLY A 320
ILE A 322
THR A 247
 FMN  A1337 (-3.4A)
None
None
None
ORO  A1338 ( 2.6A)
 0.82A 3el4B-1f76A:
undetectable		 3el4B-1f76A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 10 ALA A  61
ILE A 298
GLY A 320
ILE A 322
THR A 247
 FMN  A1337 (-3.4A)
None
None
None
ORO  A1338 ( 2.6A)
 0.90A 3el9B-1f76A:
undetectable		 3el9B-1f76A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 5 LEU A  74
GLY A  75
PHE A  79
PHE A 321
 None
 1.14A 3smtA-1f76A:
0.0		 3smtA-1f76A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 11 ALA A  61
ILE A 298
GLY A 320
ILE A 322
THR A 247
 FMN  A1337 (-3.4A)
None
None
None
ORO  A1338 ( 2.6A)
 0.92A 3spkA-1f76A:
undetectable		 3spkA-1f76A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 12 ALA A  61
ILE A 298
GLY A 320
ILE A 322
THR A 247
 FMN  A1337 (-3.4A)
None
None
None
ORO  A1338 ( 2.6A)
 1.01A 3spkB-1f76A:
undetectable		 3spkB-1f76A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 7 GLY A 119
ASP A  67
VAL A 127
ILE A 140
 None
 0.76A 3t3cA-1f76A:
undetectable		 3t3cA-1f76A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_2
(POL POLYPROTEIN)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 9 ALA A  73
ASP A  72
GLY A  78
ILE A 329
LEU A  64
 None
 1.20A 3u7sB-1f76A:
undetectable		 3u7sB-1f76A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 12 LEU A  52
LEU A  74
PHE A  54
ASN A  56
ALA A  61
 None
None
None
None
FMN  A1337 (-3.4A)
 1.04A 3uwlB-1f76A:
0.0		 3uwlB-1f76A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 12 LEU A  52
LEU A  74
PHE A  54
ASN A  56
ALA A  61
 None
None
None
None
FMN  A1337 (-3.4A)
 1.03A 3uwlD-1f76A:
0.0		 3uwlD-1f76A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6N_A_T1CA392_1
(TETX2 PROTEIN)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 11 GLY A  94
ALA A  62
GLY A  63
GLU A  83
ASN A 139
 None
FMN  A1337 (-3.7A)
FMN  A1337 (-3.1A)
None
FMN  A1337 (-3.3A)
 1.27A 4a6nA-1f76A:
undetectable		 4a6nA-1f76A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 12 THR A 334
PRO A  43
ILE A 308
VAL A 315
ILE A 317
 None
 1.42A 4eb6B-1f76A:
undetectable
4eb6C-1f76A:
undetectable		 4eb6B-1f76A:
19.78
4eb6C-1f76A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 12 TYR A 168
ILE A 293
GLY A 241
MET A  50
ILE A 197
 None
 1.14A 4iv0B-1f76A:
undetectable		 4iv0B-1f76A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 8 VAL A 230
LEU A 222
TYR A 186
ILE A 173
 None
 0.80A 4lzrA-1f76A:
undetectable		 4lzrA-1f76A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 8 GLU A  83
ILE A 293
GLN A 316
ILE A 317
 None
 0.92A 4mj8A-1f76A:
0.3		 4mj8A-1f76A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_1
(PROTEASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 11 ALA A  61
ILE A 298
GLY A 320
ILE A 322
THR A 247
 FMN  A1337 (-3.4A)
None
None
None
ORO  A1338 ( 2.6A)
 0.88A 4njtC-1f76A:
undetectable		 4njtC-1f76A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 12 GLY A 294
GLN A 316
ALA A 244
ASN A 172
ASN A 139
 None
None
None
ORO  A1338 ( 3.2A)
FMN  A1337 (-3.3A)
 1.19A 4pb1A-1f76A:
0.0		 4pb1A-1f76A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD5_A_GEOA501_1
(NUPC FAMILY PROTEIN)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 12 GLY A 294
GLN A 316
ALA A 244
ASN A 172
ASN A 139
 None
None
None
ORO  A1338 ( 3.2A)
FMN  A1337 (-3.3A)
 1.19A 4pd5A-1f76A:
0.0		 4pd5A-1f76A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 8 ILE A 293
LEU A  74
LEU A  58
ILE A 329
 None
 0.87A 4r38D-1f76A:
undetectable		 4r38D-1f76A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H3A_A_D16A401_1
(ORF70)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 7 ILE A 329
ASP A 299
GLY A 320
PHE A 321
 None
 0.91A 5h3aA-1f76A:
0.0		 5h3aA-1f76A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGL_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 VAL A 242
VAL A 216
GLN A 185
 None
 0.67A 5qglA-1f76A:
undetectable		 5qglA-1f76A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 VAL A 242
VAL A 216
GLN A 185
 None
 0.71A 5qguA-1f76A:
undetectable		 5qguA-1f76A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 ILE A 298
VAL A 315
PRO A  57
 None
 0.70A 5uunA-1f76A:
undetectable		 5uunA-1f76A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		4 / 7 TYR A 155
ALA A 189
GLY A 187
TYR A 186
 None
 1.10A 5uxdA-1f76A:
0.0		 5uxdA-1f76A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		5 / 10 GLY A  80
GLY A 134
LEU A  64
ILE A  71
LEU A  74
 None
 1.03A 5vm8B-1f76A:
undetectable		 5vm8B-1f76A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 LYS A 217
ASN A 172
SER A 175
 FMN  A1337 (-2.8A)
ORO  A1338 ( 3.2A)
ORO  A1338 (-3.0A)
 1.25A 5yw0A-1f76A:
0.0		 5yw0A-1f76A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1f76 DIHYDROOROTATE
DEHYDROGENASE
(QUINONE)
(Escherichia
coli) 		3 / 3 GLY A 119
ASP A  67
ILE A  84
 None
 0.40A 6dgxB-1f76A:
0.0		 6dgxB-1f76A:
12.61