SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f7u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 TYR A 471
VAL A 405
ILE A 167
GLY A 161
 None
 0.96A 11gsA-1f7uA:
2.5		 11gsA-1f7uA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_A_RBFA501_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A  48
SER A  44
ILE A  54
ILE A  78
LEU A  76
 None
 1.20A 1kyvA-1f7uA:
3.3
1kyvE-1f7uA:
4.2		 1kyvA-1f7uA:
14.33
1kyvE-1f7uA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_C_RBFC503_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  78
LEU A  76
GLY A  48
SER A  44
ILE A  54
 None
 1.20A 1kyvB-1f7uA:
3.4
1kyvC-1f7uA:
4.0		 1kyvB-1f7uA:
14.33
1kyvC-1f7uA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 5 ASP A  68
MET A  64
ASN A 115
TYR A 553
 None
 1.15A 1nbiA-1f7uA:
0.0		 1nbiA-1f7uA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 11 HIS A 159
GLY A 161
HIS A 162
ILE A 371
VAL A 405
 None
None
None
ARG  A 800 (-4.2A)
None
 0.70A 1pg2A-1f7uA:
21.7		 1pg2A-1f7uA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 121
ILE A  31
THR A 129
 None
 0.80A 1rx3A-1f7uA:
0.0		 1rx3A-1f7uA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_1
(HEMK PROTEIN)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 4 THR A 349
GLY A 343
ASP A 342
ALA A 321
 None
None
None
C  B 974 ( 3.8A)
 1.23A 1sg9A-1f7uA:
2.8		 1sg9A-1f7uA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 584
LEU A 557
VAL A 591
VAL A 123
 None
 1.01A 2bdmA-1f7uA:
2.1		 2bdmA-1f7uA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 132
GLN A 590
HIS A 493
ARG A 597
 None
 1.24A 3b9lA-1f7uA:
1.6		 3b9lA-1f7uA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 119
GLY A 532
GLN A 533
LEU A 584
ILE A 127
 None
 1.34A 3h52A-1f7uA:
undetectable		 3h52A-1f7uA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 471
VAL A 405
ILE A 167
GLY A 161
 None
 0.95A 3n9jA-1f7uA:
2.5		 3n9jA-1f7uA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 170
ILE A 184
VAL A 183
 None
 0.44A 3nv6A-1f7uA:
0.0		 3nv6A-1f7uA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CCQ_A_ACTA1317_0
(THIOREDOXIN
REDUCTASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 240
GLU A 241
SER A 243
 None
 0.74A 4ccqA-1f7uA:
4.2		 4ccqA-1f7uA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 207
PHE A 269
ILE A 265
PHE A 196
 None
 0.92A 4fglC-1f7uA:
4.4		 4fglC-1f7uA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 121
ILE A  31
THR A 129
 None
 0.75A 4gh8A-1f7uA:
undetectable		 4gh8A-1f7uA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 419
LEU A 418
PHE A 158
 None
 0.53A 4pthA-1f7uA:
0.0		 4pthA-1f7uA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 6 GLY A 207
PHE A 269
ILE A 265
PHE A 196
 None
 1.05A 4qogA-1f7uA:
4.2
4qogB-1f7uA:
4.4		 4qogA-1f7uA:
18.06
4qogB-1f7uA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 294
ARG A 350
GLN A 375
 A  B 976 ( 2.6A)
A  B 976 ( 3.1A)
ARG  A 800 (-3.5A)
 0.94A 4rtbA-1f7uA:
undetectable		 4rtbA-1f7uA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 324
ALA A 336
ALA A 380
LEU A 333
PHE A 309
 None
 1.33A 4zo1X-1f7uA:
0.9		 4zo1X-1f7uA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 358
ARG A 270
ASP A 191
TYR A 188
 ARG  A 800 ( 4.6A)
None
None
ARG  A 800 (-4.0A)
 1.49A 5a06C-1f7uA:
2.9		 5a06C-1f7uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 358
ARG A 270
ASP A 191
TYR A 188
 ARG  A 800 ( 4.6A)
None
None
ARG  A 800 (-4.0A)
 1.50A 5a06D-1f7uA:
2.8		 5a06D-1f7uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 358
ARG A 270
ASP A 191
TYR A 188
 ARG  A 800 ( 4.6A)
None
None
ARG  A 800 (-4.0A)
 1.49A 5a06E-1f7uA:
2.6		 5a06E-1f7uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 358
ARG A 270
ASP A 191
TYR A 188
 ARG  A 800 ( 4.6A)
None
None
ARG  A 800 (-4.0A)
 1.47A 5a06F-1f7uA:
2.4		 5a06F-1f7uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 127
PRO A 535
VAL A 591
ASP A 133
GLY A 135
 None
 1.12A 5nnaB-1f7uA:
undetectable		 5nnaB-1f7uA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 127
PRO A 535
VAL A 591
ASP A 133
GLY A 135
 None
 1.16A 5nnaC-1f7uA:
undetectable		 5nnaC-1f7uA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 532
ARG A 130
VAL A 123
ASP A 126
 None
 1.04A 5vlmA-1f7uA:
1.2		 5vlmA-1f7uA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 598
VAL A 550
LEU A 554
VAL A 537
 None
 0.96A 5x7zA-1f7uA:
2.0		 5x7zA-1f7uA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1f7u ARGINYL-TRNA
SYNTHETASE
(Saccharomyces
cerevisiae) 		3 / 3 LYS A   2
ASN A   6
SER A   9
 None
 1.11A 5yw0A-1f7uA:
0.0		 5yw0A-1f7uA:
20.81