SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 ILE A 218
ALA A 181
GLY A 203
LEU A 234
LEU A 208
 None
 0.98A 1rjdA-1f8fA:
3.9		 1rjdA-1f8fA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 ILE A 218
ALA A 181
GLY A 203
LEU A 234
LEU A 208
 None
 0.99A 1rjdB-1f8fA:
3.6		 1rjdB-1f8fA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 ILE A 218
ALA A 181
GLY A 203
LEU A 234
LEU A 208
 None
 0.98A 1rjdC-1f8fA:
3.4		 1rjdC-1f8fA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 11 ALA A 286
THR A 177
VAL A 288
LEU A 279
VAL A 259
 None
NAD  A 375 (-3.6A)
NAD  A 375 (-4.4A)
None
None
 1.14A 1rv7A-1f8fA:
0.0
1rv7B-1f8fA:
0.0		 1rv7A-1f8fA:
15.72
1rv7B-1f8fA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 GLY A 169
GLY A 172
GLY A 174
VAL A  87
ILE A 165
 None
None
NAD  A 375 ( 4.7A)
None
None
 1.03A 2b25A-1f8fA:
7.3		 2b25A-1f8fA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 9 ILE A 240
ILE A 219
VAL A 195
THR A 196
ALA A 199
 None
 1.14A 2m9qA-1f8fA:
undetectable		 2m9qA-1f8fA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		4 / 7 ILE A  26
ARG A  27
ASP A 120
GLU A  33
 None
 1.13A 2qebA-1f8fA:
0.0		 2qebA-1f8fA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		4 / 7 ILE A  26
ARG A  27
ASP A 120
GLU A  33
 None
 1.08A 2qebB-1f8fA:
0.0		 2qebB-1f8fA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFX_A_VGHA9000_1
(TYROSINE-PROTEIN
KINASE RECEPTOR)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 8 LEU A 186
ALA A 286
GLY A 283
LEU A 279
GLY A 275
 None
 1.40A 2yfxA-1f8fA:
undetectable		 2yfxA-1f8fA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 9 LEU A 171
ILE A 175
GLY A 174
LEU A 168
SER A  68
 None
None
NAD  A 375 ( 4.7A)
None
None
 0.99A 3ai9X-1f8fA:
undetectable		 3ai9X-1f8fA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D4S_A_TIMA401_2
(BETA-2 ADRENERGIC
RECEPTOR/T4-LYSOZYME
CHIMERA)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 THR A  41
SER A 144
PHE A  19
 None
 0.88A 3d4sA-1f8fA:
undetectable		 3d4sA-1f8fA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 11 GLY A  75
GLY A  31
ILE A  26
SER A 151
VAL A  34
 None
 0.98A 3dcmX-1f8fA:
3.4		 3dcmX-1f8fA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 SER A 144
GLY A  64
GLY A 169
LEU A 167
ASP A 340
 None
 1.00A 3gczA-1f8fA:
3.7		 3gczA-1f8fA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 PHE A 140
CYH A 173
HIS A  65
 EOH  A 374 (-4.6A)
ZN  A 372 ( 2.1A)
ZN  A 372 (-3.4A)
 1.04A 3u9fF-1f8fA:
0.0		 3u9fF-1f8fA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 PHE A 140
CYH A 173
HIS A  65
 EOH  A 374 (-4.6A)
ZN  A 372 ( 2.1A)
ZN  A 372 (-3.4A)
 1.10A 3u9fG-1f8fA:
0.0		 3u9fG-1f8fA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 PHE A 140
CYH A 173
HIS A  65
 EOH  A 374 (-4.6A)
ZN  A 372 ( 2.1A)
ZN  A 372 (-3.4A)
 1.10A 3u9fL-1f8fA:
0.0		 3u9fL-1f8fA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 PHE A 140
CYH A 173
HIS A  65
 EOH  A 374 (-4.6A)
ZN  A 372 ( 2.1A)
ZN  A 372 (-3.4A)
 1.04A 3u9fS-1f8fA:
0.0		 3u9fS-1f8fA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 11 ALA A  61
LEU A  63
ILE A 351
LEU A  59
GLY A  16
 None
 1.05A 3zosA-1f8fA:
0.0
3zosB-1f8fA:
0.0		 3zosA-1f8fA:
21.39
3zosB-1f8fA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A3U_B_ACTB1358_0
(NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		4 / 7 ILE A 271
GLY A 198
VAL A 221
SER A 242
 None
NAD  A 375 ( 4.0A)
None
NAD  A 375 ( 3.7A)
 0.85A 4a3uB-1f8fA:
undetectable		 4a3uB-1f8fA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 LEU A 342
GLY A 178
GLY A 317
LEU A 204
GLY A 198
 None
None
None
None
NAD  A 375 ( 4.0A)
 0.93A 4blvA-1f8fA:
5.0		 4blvA-1f8fA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		4 / 7 GLY A  64
THR A  41
ILE A 370
PHE A 348
 None
 0.68A 4ejjA-1f8fA:
0.0		 4ejjA-1f8fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		4 / 7 GLY A  64
THR A  41
ILE A 370
PHE A 348
 None
 0.79A 4ejjD-1f8fA:
0.0		 4ejjD-1f8fA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 ALA A 215
ILE A 254
ILE A 251
THR A 196
VAL A 259
 None
 1.05A 4nkvC-1f8fA:
undetectable		 4nkvC-1f8fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 ALA A 215
ILE A 254
ILE A 251
THR A 196
VAL A 259
 None
 1.05A 4nkvD-1f8fA:
undetectable		 4nkvD-1f8fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 9 ALA A 209
TYR A  91
GLY A 317
ALA A 181
VAL A 202
 None
None
None
None
NAD  A 375 (-3.6A)
 1.15A 4r1zA-1f8fA:
undetectable		 4r1zA-1f8fA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 GLY A 200
ALA A 201
SER A 205
ILE A 223
SER A 242
 NAD  A 375 (-3.3A)
NAD  A 375 (-4.1A)
None
NAD  A 375 ( 4.4A)
NAD  A 375 ( 3.7A)
 1.30A 4rtpA-1f8fA:
4.7		 4rtpA-1f8fA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		4 / 4 ALA A 181
VAL A 202
GLY A 198
THR A 196
 None
NAD  A 375 (-3.6A)
NAD  A 375 ( 4.0A)
None
 1.06A 4ubeA-1f8fA:
5.0		 4ubeA-1f8fA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 GLY A 267
LEU A  48
PHE A  19
ILE A 351
GLY A  64
 None
 1.18A 5eskA-1f8fA:
undetectable		 5eskA-1f8fA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 ALA A 220
GLY A 289
GLY A 203
LEU A 204
GLY A 275
 None
NAD  A 375 ( 3.7A)
None
None
None
 1.06A 5i75A-1f8fA:
0.0		 5i75A-1f8fA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 12 SER A  68
LEU A 168
GLY A 169
PRO A 170
LEU A 167
 None
 1.46A 5jo9A-1f8fA:
8.7		 5jo9A-1f8fA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		4 / 4 LEU A 364
LEU A 204
SER A 226
ALA A 231
 None
 0.91A 5uunA-1f8fA:
undetectable		 5uunA-1f8fA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 THR A 177
GLU A 316
HIS A  65
 NAD  A 375 (-3.6A)
NAD  A 375 ( 4.3A)
ZN  A 372 (-3.4A)
 0.62A 5xioA-1f8fA:
3.4		 5xioA-1f8fA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 THR A 177
GLU A 316
HIS A  65
 NAD  A 375 (-3.6A)
NAD  A 375 ( 4.3A)
ZN  A 372 (-3.4A)
 0.67A 5xiqB-1f8fA:
undetectable		 5xiqB-1f8fA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 THR A 177
GLU A 316
HIS A  65
 NAD  A 375 (-3.6A)
NAD  A 375 ( 4.3A)
ZN  A 372 (-3.4A)
 0.69A 5xiqD-1f8fA:
2.2		 5xiqD-1f8fA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		4 / 9 ASP A  47
LEU A 364
VAL A 202
SER A 205
 None
None
NAD  A 375 (-3.6A)
None
 0.94A 6c2mD-1f8fA:
0.0		 6c2mD-1f8fA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		3 / 3 LEU A   4
ASN A 124
LEU A 150
 None
 0.68A 6exiA-1f8fA:
9.8		 6exiA-1f8fA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1f8f BENZYL ALCOHOL
DEHYDROGENASE
(Acinetobacter
calcoaceticus) 		5 / 8 GLY A 169
VAL A 157
GLY A  64
SER A 144
ALA A 149
 None
 1.17A 6hu9H-1f8fA:
undetectable
6hu9e-1f8fA:
undetectable		 6hu9H-1f8fA:
13.31
6hu9e-1f8fA:
17.63