SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA154_1
(CALMODULIN)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 10 GLU A 166
GLU A 163
ALA A 164
LEU A 185
GLU A 200
 None
FAD  A 448 ( 4.3A)
None
None
None
 1.45A 1a29A-1f8wA:
undetectable		 1a29A-1f8wA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 7 ALA A  15
GLU A  18
LEU A  19
VAL A   3
 None
 0.94A 1hk2A-1f8wA:
0.0		 1hk2A-1f8wA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 11 GLY A  12
GLY A   7
ILE A 109
LEU A   6
GLY A 306
 None
FAD  A 448 (-3.2A)
None
FAD  A 448 (-4.4A)
None
 0.87A 1jg3A-1f8wA:
3.1		 1jg3A-1f8wA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG3_B_ADNB550_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 11 GLY A  12
GLY A   7
ILE A 109
LEU A   6
GLY A 306
 None
FAD  A 448 (-3.2A)
None
FAD  A 448 (-4.4A)
None
 0.87A 1jg3B-1f8wA:
3.8		 1jg3B-1f8wA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 6 TYR A 217
GLU A 117
PRO A 115
VAL A 242
 None
 1.37A 1q13A-1f8wA:
undetectable		 1q13A-1f8wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_A_SAMA302_0
(HYPOTHETICAL PROTEIN
PH0226)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 12 ALA A 165
GLY A 161
ALA A 169
ILE A 208
PHE A 332
 None
 1.15A 1ve3A-1f8wA:
4.2		 1ve3A-1f8wA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 12 ALA A 165
GLY A 161
ALA A 169
ILE A 208
PHE A 332
 None
 1.14A 1ve3B-1f8wA:
4.0		 1ve3B-1f8wA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 4 ASP A 182
ASP A 179
ASP A 195
GLY A 186
 None
 1.49A 2igtC-1f8wA:
3.6		 2igtC-1f8wA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 12 ALA A 302
GLY A   7
LYS A  33
GLU A  78
ILE A  79
 FAD  A 448 ( 3.7A)
FAD  A 448 (-3.2A)
FAD  A 448 (-4.6A)
None
FAD  A 448 (-4.4A)
 1.06A 2plwA-1f8wA:
3.8		 2plwA-1f8wA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_B_ASDB1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 6 PHE A 422
LEU A 377
ALA A 407
ALA A 420
 None
 0.99A 2vcvB-1f8wA:
1.1		 2vcvB-1f8wA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 9 ILE A 162
GLY A 158
TYR A 159
GLY A 186
PHE A 336
 None
None
FAD  A 448 (-4.8A)
None
None
 1.38A 2y7wA-1f8wA:
undetectable		 2y7wA-1f8wA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 12 ILE A 108
ILE A 109
GLY A  11
LEU A   6
ALA A 299
 None
None
FAD  A 448 (-3.7A)
FAD  A 448 (-4.4A)
FAD  A 448 (-3.4A)
 1.03A 2yvlA-1f8wA:
2.9		 2yvlA-1f8wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 12 ILE A 108
ILE A 109
GLY A  11
LEU A   6
ALA A 299
 None
None
FAD  A 448 (-3.7A)
FAD  A 448 (-4.4A)
FAD  A 448 (-3.4A)
 1.03A 2yvlB-1f8wA:
3.3		 2yvlB-1f8wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 12 THR A 283
ILE A 296
GLY A 280
ALA A 297
LEU A 298
 None
None
FAD  A 448 (-3.1A)
FAD  A 448 (-4.6A)
FAD  A 448 (-3.7A)
 1.05A 2yvlC-1f8wA:
3.3		 2yvlC-1f8wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 12 THR A 283
ILE A 296
GLY A 280
ALA A 297
LEU A 298
 None
None
FAD  A 448 (-3.1A)
FAD  A 448 (-4.6A)
FAD  A 448 (-3.7A)
 1.06A 2yvlD-1f8wA:
3.1		 2yvlD-1f8wA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		3 / 3 ASP A 190
PHE A 193
LEU A 197
 None
 0.69A 2zi9A-1f8wA:
undetectable		 2zi9A-1f8wA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A51_A_VDYA6178_1
(VITAMIN D
HYDROXYLASE)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 11 ILE A 263
LEU A 255
ILE A  82
PRO A 111
LEU A   6
 None
None
None
None
FAD  A 448 (-4.4A)
 1.25A 3a51A-1f8wA:
0.0		 3a51A-1f8wA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 10 SER A  38
TYR A  60
VAL A  16
GLY A  11
GLY A  12
 None
None
None
FAD  A 448 (-3.7A)
None
 1.45A 3ixlA-1f8wA:
1.1		 3ixlA-1f8wA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 6 SER A 326
THR A 398
ILE A 401
THR A 300
 None
None
None
FAD  A 448 (-3.8A)
 1.07A 4acbC-1f8wA:
2.2		 4acbC-1f8wA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 11 ALA A 420
ASN A 433
PHE A 375
VAL A 358
ILE A 434
 None
 1.15A 4claA-1f8wA:
0.0		 4claA-1f8wA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 11 THR A 339
ALA A 389
LEU A 391
PHE A 375
SER A 405
 None
 1.21A 4claA-1f8wA:
0.0		 4claA-1f8wA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 6 ASN A  76
LEU A  94
VAL A  95
ASP A  35
 None
 0.90A 4g24A-1f8wA:
undetectable		 4g24A-1f8wA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G77_A_TLFA711_0
(LACTOTRANSFERRIN)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 7 ILE A 263
LEU A 255
ALA A 278
VAL A 279
 None
 0.56A 4g77A-1f8wA:
undetectable		 4g77A-1f8wA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 7 ALA A 389
LEU A 391
THR A 339
SER A 326
 None
 1.14A 4iklA-1f8wA:
undetectable
4iklB-1f8wA:
undetectable		 4iklA-1f8wA:
15.23
4iklB-1f8wA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 10 VAL A  89
TYR A 104
VAL A  91
LEU A 255
LEU A 251
 None
 1.33A 4jtqA-1f8wA:
undetectable		 4jtqA-1f8wA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 6 GLU A  27
GLN A  29
VAL A  91
THR A  90
 None
 1.31A 4lnxA-1f8wA:
0.0		 4lnxA-1f8wA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		5 / 12 ILE A  28
VAL A   5
GLY A  11
LEU A  19
LEU A  20
 None
None
FAD  A 448 (-3.7A)
None
None
 0.97A 4o1zA-1f8wA:
0.0		 4o1zA-1f8wA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		3 / 3 ALA A 309
ASN A 312
LEU A 313
 None
 0.44A 5i1nC-1f8wA:
undetectable		 5i1nC-1f8wA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		3 / 3 ALA A 309
ASN A 312
LEU A 313
 None
 0.50A 5i1pD-1f8wA:
0.0		 5i1pD-1f8wA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 8 GLY A 322
GLU A 267
GLN A 385
ASP A 291
 None
 0.97A 5vlmD-1f8wA:
0.0		 5vlmD-1f8wA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 8 PHE A 277
ILE A 108
ASN A 312
PRO A  24
 None
 0.97A 5x23A-1f8wA:
0.0		 5x23A-1f8wA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 5 VAL A  91
THR A  77
VAL A 276
LEU A 251
 None
 0.99A 6bqgA-1f8wA:
undetectable		 6bqgA-1f8wA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 1f8w NADH PEROXIDASE
(Enterococcus
faecalis) 		4 / 5 ILE A 414
GLN A 445
THR A 383
LEU A 387
 None
 1.13A 6f3mD-1f8wA:
3.8		 6f3mD-1f8wA:
23.23