SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		4 / 6 HIS A 140
GLY A 141
ALA A  43
GLU A  39
 None
 0.82A 1dmaB-1f99A:
undetectable		 1dmaB-1f99A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		5 / 12 LEU A 142
ALA A  40
LEU A  44
ALA A  48
ILE A 154
 None
 0.94A 1fk6A-1f99A:
undetectable		 1fk6A-1f99A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		3 / 3 LEU A  92
VAL A  95
LEU A  99
 None
 0.47A 1mz9B-1f99A:
undetectable		 1mz9B-1f99A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		4 / 6 ARG A  33
ASP A 155
ASN A 138
GLU A 149
 None
 1.08A 1rjdA-1f99A:
undetectable		 1rjdA-1f99A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		4 / 6 ARG A  33
ASP A 155
ASN A 138
GLU A 149
 None
 1.10A 1rjdB-1f99A:
undetectable		 1rjdB-1f99A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		4 / 6 ARG A  33
ASP A 155
ASN A 138
GLU A 149
 None
 1.12A 1rjdC-1f99A:
undetectable		 1rjdC-1f99A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1f99 R-PHYCOCYANIN
R-PHYCOCYANIN
(Polysiphonia
urceolata;
Polysiphonia
urceolata) 		5 / 10 TYR B  95
ALA A  10
ALA A  12
GLU A  23
ALA A  11
 None
 1.34A 2r2vC-1f99B:
0.8
2r2vF-1f99B:
0.7
2r2vG-1f99B:
0.0		 2r2vC-1f99B:
12.65
2r2vF-1f99B:
12.65
2r2vG-1f99B:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		4 / 8 LEU A  24
ALA A   8
LEU A   5
ALA B  99
 PEB  B 355 ( 4.5A)
None
None
None
 0.90A 2vcvF-1f99A:
undetectable		 2vcvF-1f99A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		5 / 12 ILE B  51
PHE B 164
ALA B  99
LEU A  19
ILE B  44
 None
 1.31A 2xkwB-1f99B:
undetectable		 2xkwB-1f99B:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		3 / 3 GLU A   7
ASP A 108
TYR A 156
 None
 0.74A 2yvlB-1f99A:
undetectable		 2yvlB-1f99A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP3_B_RBTB1129_1
(B-CELL LYMPHOMA 6
PROTEIN)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		4 / 7 ASN B  35
LEU B  38
ARG B  37
TYR A  31
 PEB  B 355 (-3.5A)
PEB  B 355 ( 4.2A)
None
None
 0.90A 4cp3A-1f99B:
0.0
4cp3B-1f99B:
0.9		 4cp3A-1f99B:
20.81
4cp3B-1f99B:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		4 / 7 HIS A 140
GLY A 141
ALA A  43
GLU A  39
 None
 0.90A 4hyfA-1f99A:
undetectable		 4hyfA-1f99A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 1f99 R-PHYCOCYANIN
(Polysiphonia
urceolata) 		4 / 8 HIS A 140
GLY A 141
ALA A  43
GLU A  39
 None
 0.90A 4hyfC-1f99A:
undetectable		 4hyfC-1f99A:
20.16