SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1f9a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_B_ADNB1246_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		4 / 8 ARG A 130
GLY A   7
GLU A  44
ILE A   6
 ATP  A 700 (-2.7A)
ATP  A 700 (-3.6A)
None
None
 0.88A 1pk7B-1f9aA:
undetectable		 1pk7B-1f9aA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		3 / 3 SER A 125
GLY A 126
THR A 127
 ATP  A 700 (-4.3A)
ATP  A 700 (-3.7A)
ATP  A 700 (-3.8A)
 0.20A 3k9wA-1f9aA:
16.4		 3k9wA-1f9aA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		5 / 10 TYR A  68
ILE A  31
ILE A  32
ILE A  20
ILE A  23
 None
 0.93A 3p4wE-1f9aA:
0.0		 3p4wE-1f9aA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		4 / 7 GLU A 112
GLU A 107
TYR A 111
GLY A   3
 None
 0.99A 4fgzA-1f9aA:
2.4		 4fgzA-1f9aA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		4 / 8 PRO A  46
ARG A   8
VAL A 157
GLY A 156
 None
ATP  A 700 (-3.0A)
None
None
 0.98A 4mk4A-1f9aA:
undetectable		 4mk4A-1f9aA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		4 / 5 TYR A  68
ARG A   2
ASP A  93
VAL A 102
 None
 1.47A 4nkvB-1f9aA:
0.0		 4nkvB-1f9aA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		5 / 9 GLY A   3
VAL A 102
GLY A  33
ILE A  70
VAL A  82
 None
 1.04A 5kr0B-1f9aA:
undetectable		 5kr0B-1f9aA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		4 / 7 TYR A  68
ILE A  31
ILE A  32
ILE A  23
 None
 0.94A 5murB-1f9aA:
undetectable		 5murB-1f9aA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 102
PHE A   4
ILE A  30
PHE A   9
VAL A  95
 None
None
None
ATP  A 700 (-4.9A)
None
 1.34A 6ap6A-1f9aA:
undetectable		 6ap6A-1f9aA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A 102
PHE A   4
ILE A  30
PHE A   9
VAL A  95
 None
None
None
ATP  A 700 (-4.9A)
None
 1.33A 6ap6B-1f9aA:
1.6		 6ap6B-1f9aA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  33
GLY A  35
ALA A  37
ILE A  31
PRO A  90
 None
 1.06A 6b3aA-1f9aA:
2.7		 6b3aA-1f9aA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3B_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		5 / 12 GLY A  33
GLY A  35
ALA A  37
ILE A  31
PRO A  90
 None
 1.06A 6b3bA-1f9aA:
2.7		 6b3bA-1f9aA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		4 / 7 GLY A   7
PHE A   9
HIS A  16
SER A 125
 ATP  A 700 (-3.6A)
ATP  A 700 (-4.9A)
ATP  A 700 (-4.2A)
ATP  A 700 (-4.3A)
 0.27A 6jnhA-1f9aA:
15.5		 6jnhA-1f9aA:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1f9a HYPOTHETICAL PROTEIN
MJ0541
(Methanocaldococc
us
jannaschii) 		4 / 5 ILE A   5
ARG A   2
THR A  66
LEU A  65
 ATP  A 700 (-4.5A)
None
None
None
 0.88A 6nmpN-1f9aA:
0.0
6nmpW-1f9aA:
undetectable		 6nmpN-1f9aA:
15.18
6nmpW-1f9aA:
16.36