SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fa7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1fa7 GLYOXALASE I
(Escherichia
coli) 		4 / 5 ALA A  42
TYR A  20
ILE A  17
ASP A 115
 None
 1.14A 1upfC-1fa7A:
undetectable		 1upfC-1fa7A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 1fa7 GLYOXALASE I
(Escherichia
coli) 		5 / 12 ILE A 121
LEU A  57
THR A   6
ILE A  75
TYR A  72
 None
 1.05A 2cd2A-1fa7A:
undetectable		 2cd2A-1fa7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 1fa7 GLYOXALASE I
(Escherichia
coli) 		4 / 8 VAL A  23
LEU A  24
ILE A  75
THR A  97
 None
 0.94A 4ma7A-1fa7A:
undetectable		 4ma7A-1fa7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 1fa7 GLYOXALASE I
(Escherichia
coli) 		4 / 7 ILE A  75
HIS A   5
LEU A   3
ALA A  53
 None
CD  A1200 (-3.4A)
None
None
 1.01A 5hrqE-1fa7A:
undetectable
5hrqF-1fa7A:
undetectable
5hrqJ-1fa7A:
undetectable		 5hrqE-1fa7A:
8.15
5hrqF-1fa7A:
9.38
5hrqJ-1fa7A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_G_ZOLG401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)		 1fa7 GLYOXALASE I
(Escherichia
coli) 		4 / 7 ASP A 117
ASP A 115
ARG A  15
TYR A  59
 None
 1.44A 6g31G-1fa7A:
undetectable		 6g31G-1fa7A:
23.14