SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1faw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 1faw HEMOGLOBIN (ALPHA
SUBUNIT)
(Anser
anser) 		4 / 6 HIS A  50
GLY A  51
ALA A  26
GLU A  23
 None
 0.93A 1dmaB-1fawA:
undetectable		 1dmaB-1fawA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1faw HEMOGLOBIN (ALPHA
SUBUNIT)
(Anser
anser) 		4 / 7 PHE A  43
PHE A  46
VAL A  62
HIS A  87
 HEM  A 150 (-4.0A)
HEM  A 150 (-4.6A)
HEM  A 150 (-4.2A)
HEM  A 150 (-3.4A)
 0.96A 1lh6A-1fawA:
13.4		 1lh6A-1fawA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 1faw HEMOGLOBIN (ALPHA
SUBUNIT)
(Anser
anser) 		5 / 10 PHE A 128
LEU A 136
HIS A  87
ILE A  76
ALA A  65
 None
None
HEM  A 150 (-3.4A)
None
HEM  A 150 ( 4.0A)
 1.00A 2bxeB-1fawA:
2.4		 2bxeB-1fawA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1faw HEMOGLOBIN (ALPHA
SUBUNIT)
(Anser
anser) 		5 / 10 ILE A  73
ILE A  76
VAL A 135
GLY A 133
LEU A 125
 None
 1.20A 3em0A-1fawA:
0.0		 3em0A-1fawA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1faw HEMOGLOBIN (ALPHA
SUBUNIT)
(Anser
anser) 		3 / 3 PHE A  46
SER A  52
GLN A  54
 HEM  A 150 (-4.6A)
None
None
 0.94A 3smtA-1fawA:
undetectable		 3smtA-1fawA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 1faw HEMOGLOBIN (ALPHA
SUBUNIT)
(Anser
anser) 		5 / 12 PHE A 105
PHE A  98
HIS A  87
THR A  28
LEU A  29
 None
HEM  A 150 ( 4.2A)
HEM  A 150 (-3.4A)
None
None
 1.16A 4ac0A-1fawA:
undetectable		 4ac0A-1fawA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1faw HEMOGLOBIN (ALPHA
SUBUNIT)
(Anser
anser) 		4 / 7 PHE A  46
SER A  52
ALA A  26
LEU A  29
 HEM  A 150 (-4.6A)
None
None
None
 1.10A 4xk8A-1fawA:
undetectable		 4xk8A-1fawA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1faw HEMOGLOBIN (ALPHA
SUBUNIT)
(Anser
anser) 		5 / 12 VAL A  62
PHE A 128
VAL A 109
LEU A 129
VAL A 132
 HEM  A 150 (-4.2A)
None
None
None
HEM  A 150 (-4.9A)
 1.21A 5tudD-1fawA:
2.6		 5tudD-1fawA:
15.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1faw HEMOGLOBIN (ALPHA
SUBUNIT)
(Anser
anser) 		4 / 8 PRO A  95
THR A 134
THR A 137
TYR A 140
 None
 0.58A 5x2sI-1fawA:
25.7
5x2sJ-1fawA:
21.7
5x2sK-1fawA:
25.8		 5x2sI-1fawA:
70.92
5x2sJ-1fawA:
36.49
5x2sK-1fawA:
70.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_2
(CYTOCHROME P450 2C9)		 1faw HEMOGLOBIN (ALPHA
SUBUNIT)
(Anser
anser) 		4 / 4 PHE A  14
LEU A 136
LEU A 129
VAL A  62
 None
None
None
HEM  A 150 (-4.2A)
 1.35A 5xxiA-1fawA:
undetectable		 5xxiA-1fawA:
15.55