SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fb5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BZF_A_TMQA170_1
(DIHYDROFOLATE
REDUCTASE)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		5 / 12 LEU A 201
ALA A 218
HIS A 255
LEU A 245
THR A 219
 None
 1.03A 1bzfA-1fb5A:
undetectable		 1bzfA-1fb5A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_B_ACTB2002_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		4 / 6 TYR A 284
ALA A 217
THR A 247
ASN A 248
 None
 1.19A 1yvpB-1fb5A:
undetectable		 1yvpB-1fb5A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1200_1
(SERUM ALBUMIN)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		4 / 4 LEU A 179
ILE A 261
ILE A 204
ALA A 208
 None
 0.89A 2i30A-1fb5A:
0.0		 2i30A-1fb5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_C_J01C1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		5 / 12 LEU A  59
ILE A  67
ALA A 336
LEU A 349
TYR A 345
 None
 1.12A 2japC-1fb5A:
5.1		 2japC-1fb5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		5 / 12 LEU A  59
ILE A  67
ALA A 336
LEU A 349
TYR A 345
 None
 1.11A 2japD-1fb5A:
4.9		 2japD-1fb5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		5 / 12 ALA A 137
ILE A 170
LEU A  82
VAL A 142
LEU A  43
 None
 1.10A 3dzuA-1fb5A:
undetectable		 3dzuA-1fb5A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_1
(ADENOSYLHOMOCYSTEINA
SE)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		5 / 12 LEU A  59
THR A 343
ASP A  62
LEU A  74
LEU A  76
 None
 1.49A 3n58D-1fb5A:
8.6		 3n58D-1fb5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		3 / 3 LEU A 304
ARG A 330
MET A 335
 None
 0.98A 4m11C-1fb5A:
0.0		 4m11C-1fb5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		5 / 12 VAL A 142
GLY A  83
VAL A 138
LEU A 151
THR A 150
 None
 0.85A 4m2vA-1fb5A:
undetectable		 4m2vA-1fb5A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		4 / 8 ILE A 261
CYH A 303
ARG A 330
ILE A 172
 None
 0.93A 4xtaB-1fb5A:
0.0		 4xtaB-1fb5A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		5 / 12 ALA A 209
ILE A 172
THR A  49
LEU A 215
LEU A 244
 None
 1.13A 5nfjC-1fb5A:
undetectable		 5nfjC-1fb5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_1
(-)		 1fb5 ORNITHINE
TRANSCARBAMOYLASE
(Ovis
aries) 		5 / 12 LEU A  59
THR A 343
ASP A  62
LEU A  74
LEU A  76
 None
 1.45A 6gbnC-1fb5A:
5.0		 6gbnC-1fb5A:
20.69